Rabbit Anti-ARNT Recombinant Antibody (VS3-CJ838)

Name: Rabbit Anti-ARNT Recombinant Antibody (VS3-CJ838)
SKU: VS3-CJ838
Rating: 5 (1 reviews)

CAT#: VS3-CJ838

This product is a rabbit antibody that recognizes human ARNT.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & nuclear bodies.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1759/30_F11_2_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human placenta

Immunohistochemical staining of human placenta shows strong nuclear and moderate cytoplasmic positivity in trophoblastic cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1759/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1759/29_F11_1_red_green.jpg

Subcellular Location and Protein Expression Figure 4 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nuclear bodies.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1759/31_F11_1_red_green.jpg

Normal Tissue Figure 5 Cerebral cortex

Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4318/11331_B_8_5.jpg

Normal Tissue Figure 6 Colon

Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4318/11331_A_8_3.jpg

Normal Tissue Figure 7 Kidney

Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4318/11331_A_8_5.jpg

Normal Tissue Figure 8 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Spermatogonia cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4318/11331_A_4_6.jpg

Normal Tissue Figure 9 Placenta

Decidual cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Trophoblastic cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4318/11331_A_2_7.jpg

Normal Tissue Figure 10 Lymph node

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4318/11331_A_8_8.jpg

RNA Expression Figure 11 RNA cell line category: Cell line enriched (U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143437-ARNT

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Specifications

Immunogen
Recombinant protein

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human ARNT

Species Reactivity
Human

Applications
WB, IHC

Conjugate
Unconjugated

Product Property

Purification
Protein A affinity purified

Purity
>95% as determined by SDS-PAGE

Format
Liquid

Buffer
40% Glycerol, 1% BSA, TBS, pH7.4.

Preservative
0.05% Sodium Azide

Storage
Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
This antibody has been tested for use in Western Blot, Immunohistochemistry.

Target

Alternative Names
HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta

Gene ID
405

UniProt ID
P27540

Cellular Localization
Nucleus

Protein Refseq
NP_001184254.1; NP_001272964.1; NP_001272965.1

Function
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS3-CJ838.pdf

MSDS

MSDS - VS3-CJ838.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

Isotype Control

CAT
Product Name

Secondary Antibody

CAT
Product Name

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