Mouse Anti-CD28 Recombinant Antibody (VS-0624-FY71) (CAT#: VS-0624-FY71)

• Immunogen
• Human CD28 transfected cells

• Host Species
• Mouse

• Type
• Mouse IgG1 kappa

• Specificity
• Human CD28

• Species Reactivity
• Human

• Applications
• Flow Cytometry, Costimulation

• MW
• Ig superfamily, type I transmembrane glycoprotein, homodimer, 44 kD

• Related Disease
• Cancer, Autoimmune or inflammatory diseases

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS, pH 7.2

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• CD28 Molecule; CD28 Antigen; Tp44; T-Cell-Specific Surface Glycoprotein CD28; T-Cell-Specific Surface Glycoprotein; CD28 Antigen (Tp44)

• Gene ID
• 940

• UniProt ID
• P10747

• Long Name
• CD28 Molecule

• Cellular Localization
• Membrane

• Post Translation Modifications
• CD40LG induces tyrosine phosphorylation of isoform 3.
  Glycosylation at Asn37, Asn129, Asn71, Asn92, and Asn105
  Modification sites at PhosphoSitePlus (P10747)
  Glycosylation from GlyGen

• Protein Refseq
• NP_001230006.1; NP_001230007.1; NP_001397910.1; NP_006130.1

• Function
• Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
  Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933).
  Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells

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