This recombinant monoclonal antibody to HIV-1 gp41 is a Monkey monoclonal antibody that can be used for applications: ELISA, Neut.
Figure 1 DH570 mutant acquires high affinity binding and neutralization capacity in the TZM-bl neutralization assay
(A and B) BLI sensorgrams of MPER peptide-liposome binding by DH570 Fab (A) and DH570.Mut58 Fab (B) at different antibody concentrations (2, 5, 10, and 20 µg/ml). (C) Measured kinetic rates (Ka and Kd) and dissociation (Kd) constants of DH570 and DH570.Mut58 binding to MPER peptide-liposomes. (D) Neutralization activity of whole IgG1 DH570 and DH570.Mut58 against W61D in the TZM-bl assay.
Zhang, R., Verkoczy, L., Wiehe, K., Munir Alam, S., Nicely, N. I., Santra, S., ... & Haynes, B. F. (2016). Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Science translational medicine, 8(336), 336ra62-336ra62.
Figure 2 Neutralization of the DH570 clone
Neutralization curves and (D) summary table of IC50 and IC80 for DH570 and 2F5 against HIV isolate JRFL in the monocyte-derived macrophage neutralization assay
Zhang, R., Verkoczy, L., Wiehe, K., Munir Alam, S., Nicely, N. I., Santra, S., ... & Haynes, B. F. (2016). Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Science translational medicine, 8(336), 336ra62-336ra62.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-486 | Recombinant Anti-HIV-1 gp41 Antibody | WB, Dot, FuncS | IgG |
MRO-842CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1911) | WB | Mouse IgG2a |
MRO-843CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 191) | WB | Mouse IgG2 |
MRO-844CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10E9) | WB, RIPA, ELISA, IF | Mouse IgG1 |
MRO-845CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10F6) | ELISA, WB, IP, IF | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-486-F(E) | Recombinant Anti-HIV-1 gp41 Antibody Fab Fragment | ELISA, FacS, FuncS | Fab |
MRO-4088CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone HGH8); Fab Fragment | ELISA | Human Fab |
MRO-4089CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone HGN158); Fab Fragment | ELISA | Human Fab |
MRO-4090CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone HGN36); Fab Fragment | ELISA | Human Fab |
MRO-4091CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone HGN91); Fab Fragment | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-025LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG3) | ELISA | Human antibody |
MRO-026LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG1) | ELISA | Human antibody |
MRO-040LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (M66.6) | ELISA | Human antibody |
MRO-074LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (W) | ELISA | Human antibody |
MRO-077LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (3D6) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-331 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-331) | Neut | Mouse scFv |
PSBC-332 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 10E8v4-5R+100cF); scFv Fragment | Neut | Human scFv |
PSBS-0051 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.4); scFv Fragment | ELISA, Neut, FuncS | Monkey scFv |
PSBS-0052 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.9); scFv Fragment | ELISA, FuncS | Monkey scFv |
PSBS-0053 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.mut58); scFv Fragment | ELISA, Neut, FuncS | Monkey scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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