Rabbit Anti-MSN Recombinant Antibody (VS13-YC744) (CAT#: VS13-YC744)

• Immunogen
• Recombinant human Moesin, aa 455-500.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Mouse MSN

• Species Reactivity
• Human, Mouse

• Applications
• WB, IHC-P, ICC, IF

• Conjugate
• NONE

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/1000-1/2000
  Immunocytochemistry (ICC): 1/50-1/200
  Immunofluorescence (IF): 1/50-1/200
  Immunohistochemistry-paraffin (IHC-P): 1/50-1/200

• Alternative Names
• Moesin; Membrane-Organizing Extension Spike Protein; Epididymis Luminal Protein 70; HEL70; IMD50;

• Gene ID
• 4478

• UniProt ID
• P26038

• Long Name
• Moesin

• Cellular Localization
• Cell membrane; Apical cell membrane; Microvillus membrane; Cytoskeleton

• Protein Refseq
• NP_002435.1

• Function
• Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (PubMed:10212266).
  Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (PubMed:10212266).
  These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction (PubMed:12387735, PubMed:15039356).
  The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (PubMed:9298994, PubMed:9616160).
  Modulates phagolysosomal biogenesis in macrophages (By similarity).
  Participates also in immunologic synapse formation (PubMed:27405666).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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