Rabbit Anti-NRGN Recombinant Antibody (clone R08-8K7)
CAT#: VS3-FY1799
This R08-8K7 recombinant monoclonal antibody exhibits specific binding to human NRGN protein, a calculated weight of 8 kDa. It cross-reacts with mouse, rat. The recommend antibody dilution is determined as western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200), immunoprecipitation (dilution 1/20).
Specifications
- Immunogen
- Recombinant human neurogranin protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NRGN
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-8K7
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 8 kDa, while the observed molecular weight stands at 14-16 kDa.
- Related Disease
- Hypothyroidism and Jacobsen Syndrome
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- Neurogranin; Neurogranin (Protein Kinase C Substrate, RC3); RC3; Calmodulin-Binding Protein; Protein Kinase C Substrate; Hng; Ng
- Gene ID
- 4900
- UniProt ID
- Q92686
- Sequence Similarities
- Belongs to the neurogranin family.
- Cellular Localization
- Cytosol
- Post Translation Modifications
- Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. (Q92686-NEUG_HUMAN)
Modification sites at PhosphoSitePlus (Q92686)
Modification sites at neXtProt (NX_Q92686)
- Protein Refseq
- NP_001119653.1; NP_006167.1
- Function
- Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "NRGN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1884 | Recombinant Rabbit Anti-NRGN Capture Antibody (clone R18-3A-4) | ELISA | Rabbit IgG |
| VS3-WK1885 | Recombinant Rabbit Anti-NRGN Detection Antibody (clone R55-1L-5) | ELISA | Rabbit IgG |
| VS3-WK1898 | Recombinant Rabbit Anti-NRGN Capture Antibody (clone R12-8Y-5) | ELISA | Rabbit IgG |
| VS3-WK1899 | Recombinant Rabbit Anti-NRGN Detection Antibody (clone R35-2F-4) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4983 | Anti-NRGN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4984 | Anti-Mouse NRGN Immunohistochemistry Kit | IHC |
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