Rabbit Anti-NRGN Recombinant Antibody (clone R08-8K7) (CAT#: VS3-FY1799)
This R08-8K7 recombinant monoclonal antibody exhibits specific binding to human NRGN protein, a calculated weight of 8 kDa. It cross-reacts with mouse, rat. The recommend antibody dilution is determined as western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200), immunoprecipitation (dilution 1/20).
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Custom Production
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Specifications
- Immunogen
- Recombinant human neurogranin protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat NRGN
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-8K7
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 8 kDa, while the observed molecular weight stands at 14-16 kDa.
- Related Disease
- Hypothyroidism and Jacobsen Syndrome
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- Neurogranin; Neurogranin (Protein Kinase C Substrate, RC3); RC3; Calmodulin-Binding Protein; Protein Kinase C Substrate; Hng; Ng
- Gene ID
- 4900
- UniProt ID
- Q92686
- Sequence Similarities
- Belongs to the neurogranin family.
- Cellular Localization
- Cytosol
- Post Translation Modifications
- Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. (Q92686-NEUG_HUMAN)
Modification sites at PhosphoSitePlus (Q92686)
Modification sites at neXtProt (NX_Q92686)
- Protein Refseq
- NP_001119653.1; NP_006167.1
- Function
- Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibodies
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1884 | Recombinant Rabbit Anti-NRGN Capture Antibody (clone R18-3A-4) | ELISA | Rabbit IgG |
| VS3-WK1885 | Recombinant Rabbit Anti-NRGN Detection Antibody (clone R55-1L-5) | ELISA | Rabbit IgG |
| VS3-WK1898 | Recombinant Rabbit Anti-NRGN Capture Antibody (clone R12-8Y-5) | ELISA | Rabbit IgG |
| VS3-WK1899 | Recombinant Rabbit Anti-NRGN Detection Antibody (clone R35-2F-4) | ELISA | Rabbit IgG |
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