Human Anti-PTPRC Recombinant Antibody (clone YTH54.12)
CAT#: FAMAB-1660CQ
This product is a recombinant human antibody that recognizes CD45. The antibody was purified by affinity chromatography. It can be used in Depletion, IP, FC, IF.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/if_selected.jpg
Normal Tissue
Figure 2 Appendix
Lymphoid tissue
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_3_2.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/440/155132_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, JURKAT, MOLT-4, THP-1, U-266/70, U-266/84, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000081237-PTPRC
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human CD45
- Species Reactivity
- Human
- Clone
- YTH54.12
- Applications
- Depletion, IP, FC, IF
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
- UniProt ID
- P08575
REVIEWS AND Q&AS
CITATIONS
RESOURCES
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Optimal for CD45 Research
Our lab focuses on leukocyte dynamics, and this antibody has been pivotal in our studies. Its high affinity and clear differentiation between CD45 isoforms have elevated the depth of our findings, enabling novel insights into immune cell function.
Essential for Autoimmune Studies
Studying autoimmune responses requires precision, and YTH54.12 provides just that. Its use has clarified CD45 involvement in autoimmune pathogenesis, supporting hypotheses with concrete experimental evidence.
User-Friendly Protocols
The ease of use associated with this antibody is exemplary. The detailed datasheet provides clarity on optimal usage conditions, resulting in high success rates and confidence in continuing purchases.
Q&As
-
What is the specific target of this antibody?
A: The Human Anti-PTPRC Recombinant Antibody (clone YTH54.12) specifically targets CD45, a critical protein tyrosine phosphatase involved in hematopoietic cell signaling, making it vital for research in immune cell differentiation and signaling pathways.
-
How can this antibody be applied in research?
A: It can be used in various applications such as immunoprecipitation (IP), flow cytometry (FC), and immunofluorescence (IF), facilitating the study of CD45 roles in cellular signaling processes.
-
Is this antibody conjugated to any fluorophores or enzymes?
A: This antibody is available unconjugated but can be custom-conjugated with agents like PE, APC, or biotin upon request, catering to diverse experimental needs.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone YTH54.12"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0365-CN-F(E) | Rabbit Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0365-CN-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-0366-CN-F(E) | Human Anti-PTPRC Recombinant Antibody; Fab Fragment (HPAB-0366-CN-F(E)) | ELISA, FC | Humanized Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| NS-023CN-F(E) | Mouse Anti-PTPRC Recombinant Antibody (clone ZCH-6-3A4); Fab Fragment | FC, IF | Mouse Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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