FITC-DRB1*03:01/Human E2 (PIVQLQGDSNCLKCFR) MHC Tetramer (CAT#: MHC-YF1345)
This product is a MHC tetramer of biotinylated peptide/MHC complex composed E2-derived peptide of PIVQLQGDSNCLKCFR sequence covering 285-300 and DRB1*03:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Specifications
- Allele
- DRB1*03:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- E2
- Antigen Species
- HPV
- Peptide
- PIVQLQGDSNCLKCFR
- Range
- 285-300
- Conjugate
- FITC
- Application
- FCM
Target
- Antigen Introduction
- Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
- Alternative Names
- Regulatory protein E2; E2
- Gene ID
- 1489080
- UniProt ID
- P03120
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-357 | Recombinant Human Anti-VEEV E2 Antibody (F5) | WB, ELISA, Neut, FuncS | IgG |
| HPAB-N0072-YC | Recombinant Human Anti-E2 Antibody (HC84.26.5D) | Neut, ELISA, FuncS | Human IgG |
| HPAB-N0074-YC | Recombinant Humanized Anti-E2 Antibody (TRN-1008) | Neut, ELISA, WB | Humanized IgG |
| HPAB-N0075-YC | Recombinant Human Anti-E2 Antibody (TRN-1007) | Neut, ELISA, WB | Human IgG |
| HPAB-2105-FY | Human Anti-E2 Recombinant Antibody (clone D12) | ELISA | Human IgG |
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