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For Research Use Only. Not For Clinical Use.


Background

Advances in treatment of chronic hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) have led to high cure rates of treated patients. Although rates of sustained virologic response of approximately 95% have been achieved, a large number of patients still fail treatment, even with drug combination regiments. A high percentage of these treatment failures are due to the emergence of resistance-associated variants (RAV). Chronic HCV infection consequently will continue as a leading cause of cirrhosis and hepatocellular carcinoma, which are major indications for liver transplantation.
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