Human Anti-ACE2 (clone 05B04) scFv-Fc Chimera
CAT#: VS-0425-FY8
Anti-ACE2 scFv-Fc is a recombinant protein designed to target and bind to the Angiotensin-Converting Enzyme 2 (ACE2) receptor. This product combines the benefits of single-chain variable fragments (scFv) with the Fc region of IgG, providing enhanced stability, prolonged serum half-life, and improved immunogenicity for research and therapeutic applications.
Gene Expression
Normal Tissue
Figure 1 Small intestine
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/288/170349_A_6_2_val_selected.jpg
Normal Tissue
Figure 2 Colon
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/288/170349_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Bowman's capsule Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/288/170349_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/288/170349_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (NB-4, NTERA-2, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130234-ACE2
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Specifications
- Immunogen
- Recombinant hACE2 extracellular domain (1-740 aa).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ACE2
- Species Reactivity
- Human
- Clone
- 05B04
- Applications
- Flow Cytometry, Neutralization, Immunofluorescence, ELISA
- Related Disease
- Covid-19 and Coronavirus Infectious Disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Flow Cytometry: 2 μg/mL, Neutralization: 1 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Angiotensin I Converting Enzyme 2; Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2; Angiotensin-Converting Enzyme Homolog; ACE-Related Carboxypeptidase; Metalloprotease MPROT15; Peptidyl-Dipeptidase A
- Gene ID
- 59272
- UniProt ID
- Q9BYF1
- Long Name
- Angiotensin I Converting Enzyme 2
- Sequence Similarities
- Belongs to the peptidase M2 family.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein; Cytoplasm; Cell projection, cilium; Apical cell membrane
- Post Translation Modifications
- N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form.
Also cleaved by serine proteases: TMPRSS2, TMPRSS11D and HPN/TMPRSS1.
Phosphorylated.
Phosphorylation at Tyr-781 probably inhibits interaction with AP2M1 and enables interactions with proteins containing SH2 domains.
Ubiquitinated.
Ubiquitinated on Lys-788 via 'Lys-48'-linked ubiquitin.
'Lys-48'-linked deubiquitinated by USP50 on the Lys-788; leading to its stabilization.
Glycosylation at Asn53, Asn432, Asn90, Asn103, Asn546, Asn322, Asn690, and Thr730
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ACE2_HUMAN (1012)
Glycosylation from GlyGen 19 sites, 304 N-linked glycans (8 sites), 35 O-linked glycans (11 sites)
- Protein Refseq
- NP_001358344.1; NP_001373188.1; NP_001373189.1; NP_001375381.1; NP_001376331.1
- Function
- Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis.
Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II.
Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0036 | Hi-Affi™ Rabbit Anti-ACE2 Recombinant Antibody (clone DS36AB) | IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY73 | Anti-Mouse ACE2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY72 | Anti-Human ACE2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC18 | Recombinant Anti-ACE2 Vesicular Antibody, EV Displayed (VS-0425-YC18) | ELISA, FC, Cell-uptake |
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