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BTK
Anti-BTK Recombinant Antibody Products
- AbPlus™ Anti-BTK Magnetic Beads (CBACN-075) (VS-0424-XY34)
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- Target: BTK
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
Creative Biolabs presents an unmatched array of anti-BTK recombinant antibody products designed to accelerate your research and therapeutic endeavors. Harnessing the latest in antibody engineering and production technologies, our anti-BTK antibodies exhibit superior specificity and affinity, making them ideal for advanced immunological studies and therapeutic applications. At the same time, our products are meticulously validated to ensure optimal performance in various assays to achieve your projects with efficacy and accuracy.
BTK: A Potential Therapeutic Target for Autoimmune Diseases and B Cell Malignancies
BTK, a critical tyrosine kinase for B cell function, serves as a central signaling node, integrating signals from the BCR, chemokine receptors, and TLR. Through direct interactions with five distinct molecules, BTK facilitates B cell proliferation, antibody production, and pro-inflammatory cytokine secretion, influencing B cell adhesion, migration, and the tumor microenvironment. Given its pivotal role in these physiological processes, BTK has emerged as a promising therapeutic target for autoimmune diseases and B cell-related malignancies.
Alternative Names
B-Cell Progenitor Kinase; Bruton Agammaglobulinemia Tyrosine Kinase; EC 2.7.10.2; EC 2.7.10; Agammaglobulinaemia Tyrosine Kinase; AGMX1; BPK; ATK; IMD1; Truncated Bruton Agammaglobulinemia Tyrosine Kinase; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17); Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14); Agammaglobulinemia Tyrosine Kinase; Bruton Tyrosine Kinase; PSCTK1; XLA; AT.
Background
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (granulocytes, B-cells, monocytes, Kupffer cells, Macrophages, Hofbauer cells, Plasma cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (Daudi, HEL, HMC-1, U-937)
Interaction
Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9.
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
Anti-BTK rAb Products
Creative Biolabs offers a comprehensive selection of anti-BTK recombinant antibody products designed to target and inhibit BTK. These high-affinity and specific antibodies are available in various formats, including mouse and rabbit derivations, and are applicable for a range of experimental techniques such as Western Blot, Immunoprecipitation, ELISA, Immunohistochemistry, and Immunofluorescence. Engineered to support both research and therapeutic applications, Creative Biolabs’ anti-BTK recombinant antibodies are valuable tools for advancing studies in immunology, cancer, and related fields.
Table 1. Featured anti-BTK recombinant antibody products at Creative Biolabs.
| Cat. No. | Product Name | Target Species | Host Species | Applications |
| MRO-2304-CN | Rabbit Anti-BTK Recombinant Antibody (clone CBACN-597) | Human | Rabbit IgG | WB, IP |
| MRO-0196-CN | Rabbit Anti-BTK Recombinant Antibody (clone CBACN-075) | Human | Rabbit IgG | WB, IP |
| MOB-2243z | Mouse Anti-BTK Recombinant Antibody (clone 21F12) | Human | Mouse IgG2b | WB, FC, ICC, IF, IHC |
| VS3-WK2119 | Rabbit Anti-BTK (pY223) Recombinant Antibody (clone R09-4V4) | Human | Rabbit IgG | WB, IP |
| VS-0923-FY24 | Recombinant Mouse Anti-BTK Antibody | Human | Mouse IgG2a | ELISA, WB |
Creative Quality Control
Creative Biolabs is dedicated to providing superior anti-BTK recombinant antibodies. Our unwavering commitment to quality is demonstrated by our state-of-the-art manufacturing facilities and stringent quality control protocols. Each antibody undergoes rigorous validation to ensure exceptional specificity, affinity, and purity. Our team of industry experts continually monitors and optimizes production processes to maintain the highest standards in biotechnology.
Fig.1 IHC analysis of anti-BTK antibody
(Cat# ZG-0103U, Creative Biolabs).
Fig.2 WB analysis of anti-BTK antibody
(Cat# ZG-0353F, Creative Biolabs).
Fig.3 IHC analysis of anti-BTK antibody
(Cat# ZG-0353F, Creative Biolabs).
Fig.4 IF analysis of anti-BTK antibody
(Cat# ZG-0353F, Creative Biolabs).
Fig.5 WB analysis of anti-BTK antibody
(Cat# ZG-0354F, Creative Biolabs).
Fig.6 IP analysis of anti-BTK antibody
(Cat# ZG-0354F, Creative Biolabs).
Customer Reviews
Excellent
Wh***eMouse Anti-BTK Recombinant Antibody (clone 21F12) (MOB-2243z)
I've been using this Mouse Anti-BTK Recombinant Antibody in my research, and I'm extremely impressed with its performance. The antibody consistently delivers strong, specific signals in my Western blotting experiments. The high sensitivity allows me to detect even low levels of BTK expression, which is crucial for my research. Additionally, the antibody is highly specific and doesn't cross-react with other proteins, ensuring reliable results. The overall quality and performance of this antibody have been exceptional. I would highly recommend it to anyone working with BTK research.
17/Nov/2021
Excellent
Ad***mRecombinant Mouse Anti-BTK Antibody (VS-0923-FY24) (VS-0923-FY24)
This BTK antibody has been a total game-changer for my research! It's super sensitive and picks up even the tiniest amounts of BTK. Plus, it's super specific, so I don't have to worry about any cross-reactivity. I've been using it for Western blotting, and the results have been consistently awesome. If you're working with BTK, this antibody is a must-have!
11/May/2022
Excellent
Ta***yHi-Affi™ Rabbit Anti-BTK Recombinant Antibody (clone DS393AB) (MOR-0393)
The Hi-Affi™ BTK antibody has consistently exceeded my expectations in recent months. The high affinity and specificity have been invaluable for my research. I've used it for immunocytochemistry assay and ELISA assay, and it consistently delivers excellent results. The low background staining has been a huge plus, making it easy to interpret my data. If you're looking for a reliable and high-quality BTK antibody, I highly recommend this one.
11/Oct2023
rAb Production
Our advanced anti-BTK recombinant antibody platform employs genetically engineered cells to produce high-quality antibodies targeting the BTK protein. This innovative approach enables scalable and efficient antibody production, ensuring a consistent supply for research and therapeutic applications.
Featured Anti-BTK Recombinant Antibody Production Platforms
Fig.7 Milligram-scale anti-BTK recombinant antibody production.
Fig.8 Gram-scale anti-BTK recombinant antibody production.
rAb Modalities
Creative Biolabs offers a wide range of high-quality anti-BTK recombinant antibodies in various formats, designed to meet the diverse needs of researchers.
Fig.9 Full-length anti-BTK recombinant antibody production and modalities.
Public Drug Information Targeting BTK
Table 2. Public drug targeting BTK.
| Highest Phase | Mechanism of Action | Product Category | Condition | Organization |
| Phase II |
Bruton's Tyrosine Kinase (BTK) Inhibitors Glucagon Receptor (GCGR) Agonists Glucagon-Like Peptide 1 Receptor (GLP1R) Agonists Signal Transduction Modulators |
Fc Fusion Proteins Glucagon-Like Peptide 1 (GLP-1) Analogues Pegylated Drugs Polypeptides, from 41 AA |
Diabetes type 2 Hyperlipidemia Non-alcoholic fatty liver disease (NAFLD) Non-alcoholic steatohepatitis (NASH) Obesity |
Hanmi (Originator) Janssen Pharmaceuticals (Janssen) Janssen Research & Development (Janssen) Merck & Co Merck & Co. (Merck & Co) |
| Preclinical | Stem Cell-Based Gene Therapy | Agammaglobulinemia, X-linked (Bruton syndrome) | Seattle Children's Hospital (Originator) | |
| Preclinical |
Gene Therapy Lentiviral Vectors |
Agammaglobulinemia, X-linked (Bruton syndrome) | University of Washington (Originator) | |
| Biological Testing |
Angiogenesis Inhibitors Bcr-Abl (Bcr-Abl1) Kinase Inhibitors Bruton's Tyrosine Kinase (BTK) Inhibitors Discoidin Domain-Containing Receptor 1 (DDR1) Inhibitors Discoidin Domain-Containing Receptor 2 (DDR2) Inhibitors Ephrin (EPH) Receptor Inhibitors KIT (c-KIT) (Leu576Pro Mutant) Inhibitors Macrophage Colony-Stimulating Factor 1 Receptor (CSF1R; CD115; c-Fms) Inhibitors Mast/Stem Cell Growth Factor Receptor Kit (KIT; c-KIT; CD117) Inhibitors PDGFRalpha Inhibitors Platelet-Derived Growth Factor Receptor beta (PDGFRB) Inhibitors Proto-Oncogene Tyrosine-Protein Kinase Src (SRC; SRC1) Inhibitors Signal Transduction Modulators Tyrosine Protein Kinase Blk Inhibitors Tyrosine-Protein Kinase ABL1 (ABL) Inhibitors Tyrosine-Protein Kinase CSK Inhibitors Tyrosine-Protein Kinase Fgr Inhibitors Tyrosine-Protein Kinase FRK Inhibitors Tyrosine-Protein Kinase Fyn Inhibitors Tyrosine-Protein Kinase HCK Inhibitors Tyrosine-Protein Kinase Lck Inhibitors Tyrosine-Protein Kinase Lyn Inhibitors Tyrosine-Protein Kinase Yes (YES1) Inhibitors |
Nanoparticles Peptide-Drug Conjugates |
Cancer |
Cornell University Memorial Sloan-Kettering Cancer Center |
| Biological Testing |
Bruton's Tyrosine Kinase (BTK) Inhibitors Signal Transduction Modulators |
Oligonucleotides Small Interfering RNA (SiRNAs) |
Cancer, breast | City University of New York (CUNY) (Originator) |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
BTK-Targeted Drug Information
Table 3. Therapeutic approaches targeting BTK in clinical development.
| Highest Phase | Mechanism of Action | Product Category | Condition | Organization |
| Preclinical |
Gene Therapy Lentiviral Vectors |
Agammaglobulinemia, X-linked (Bruton syndrome) | Lonza (Originator) | |
| Biological Testing |
Bruton's Tyrosine Kinase (BTK) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Signal Transduction Modulators |
Pegylated Drugs PROTACs (Proteolysis Targeting Chimeras) |
Cancer | Novartis (Originator) |
| Biological Testing |
Bruton's Tyrosine Kinase (BTK) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Signal Transduction Modulators |
Pegylated Drugs PROTACs (Proteolysis Targeting Chimeras) |
Cancer | Novartis (Originator) |
| Biological Testing |
Bruton's Tyrosine Kinase (BTK) Degradation Inducers Drugs Targeting Protein Cereblon (CRBN) Signal Transduction Modulators |
Pegylated Drugs PROTACs (Proteolysis Targeting Chimeras) |
Cancer | Novartis (Originator) |
| Biological Testing |
Angiogenesis Inhibitors Bcr-Abl (Bcr-Abl1) Kinase Inhibitors Bruton's Tyrosine Kinase (BTK) Inhibitors Discoidin Domain-Containing Receptor 1 (DDR1) Inhibitors Discoidin Domain-Containing Receptor 2 (DDR2) Inhibitors Ephrin (EPH) Receptor Inhibitors KIT (c-KIT) (Leu576Pro Mutant) Inhibitors Macrophage Colony-Stimulating Factor 1 Receptor (CSF1R; CD115; c-Fms) Inhibitors Mast/Stem Cell Growth Factor Receptor Kit (KIT; c-KIT; CD117) Inhibitors PDGFRalpha Inhibitors Platelet-Derived Growth Factor Receptor beta (PDGFRB) Inhibitors Proto-Oncogene Tyrosine-Protein Kinase Src (SRC; SRC1) Inhibitors Signal Transduction Modulators Tyrosine Protein Kinase Blk Inhibitors Tyrosine-Protein Kinase ABL1 (ABL) Inhibitors Tyrosine-Protein Kinase CSK Inhibitors Tyrosine-Protein Kinase Fgr Inhibitors Tyrosine-Protein Kinase FRK Inhibitors Tyrosine-Protein Kinase Fyn Inhibitors Tyrosine-Protein Kinase HCK Inhibitors Tyrosine-Protein Kinase Lck Inhibitors Tyrosine-Protein Kinase Lyn Inhibitors Tyrosine-Protein Kinase Yes (YES1) Inhibitors |
Oligopeptides, less than 10 AA Peptide-Drug Conjugates RGD peptides |
Cancer | Inner Mongolia Medical University (Originator) |
(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
If you want to know more about our high-quality anti-BTK recombinant products, please feel free to contact us.
Related Signaling Pathways
BCR Signaling Pathway
Related Diseases
Primary Immunodeficiency