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    CD22 & saporin

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    Anti-CD22 & saporin Products

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    • Anti-CD22 (clone 5E8)-SMCC-DM1 ADC (ADC-214CL)
      • Target: CD22
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone 7A2)-SMCC-DM1 ADC (ADC-215CL)
      • Target: CD22
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (RFB4)-mcc-DM1 ADC (ADC-028LCT)
      • Target: CD22
      • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC (ADC-194LZY)
      • Target: CD22
      • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD22 (clone 10F4v1)-SMCC-DM1 ADC (ADC-216CL)
      • Target: CD22
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone 10F4v2)-SMCC-DM1 ADC (ADC-217CL)
      • Target: CD22
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC (ADC-219CL)
      • Target: CD22
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-221CL)
      • Target: CD22
      • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone 10F4)-SMCC-DM1 ADC (ADC-223CL)
      • Target: CD22
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone RFB4)-SMCC-DM1 ADC (ADC-224CL)
      • Target: CD22
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22-MC-MMAF ADC (ADC-032LCT)
      • Target: CD22
      • Linker: Mc (maleimidocaproyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-CD22-MCC-DM1 ADC (ADC-033LCT)
      • Target: CD22
      • Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-CD22 (clone hu10F4)-MCC-DM1 ADC (ADC-027LZY)
      • Target: CD22
      • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-CD22-mc-vc-PABc-MMAE ADC (ADC-033LZY)
      • Target: CD22
      • Linker: mc-VC-PABc(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
      • Drug: MMAE (monomethyl auristatin E)
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    • Anti-CD22-mc-vc-PABc-NMS249 ADC (ADC-097LZY)
      • Target: CD22
      • Linker: mc-VC-PABc (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
      • Drug: NMS249
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    For Research Use Only. Not For Clinical Use.


    Background

    Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome.
    CD22 & saporin
    Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
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