CD22 & saporin
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Loading...- Anti-Human CD22 Recombinant Antibody (TAB-183-F(E)) (TAB-183-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fv - disulfide stabilized
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG4, κ
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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- Human Anti-CD22 Recombinant Antibody (TAB-1722CL) (TAB-1722CL)
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- Type: Human antibody
- Application: ELISA, FC, FuncS
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- Anti-Human CD22 Recombinant Antibody (RFB4) (TAB-1728CL)
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- Application: IF, FC
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- Human Anti-CD22 Recombinant Antibody (TAB-1717CL) (TAB-1717CL)
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- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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- Human Anti-CD22 Recombinant Antibody (TAB-1718CL) (TAB-1718CL)
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- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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- Human Anti-CD22 Recombinant Antibody (TAB-1719CL) (TAB-1719CL)
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- Derivation: Human
- Type: Fully human antibody
- Application: ELISA
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- Human Anti-CD22 Recombinant Antibody (TAB-1721CL) (TAB-1721CL)
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- Type: Human antibody
- Application: ELISA, FC, FuncS
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- Human Anti-CD22 Recombinant Antibody (TAB-1720CL) (TAB-1720CL)
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- Derivation: Human
- Type: Fully human antibody
- Application: ELISA
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- Mouse Anti-CD22 Recombinant Antibody (clone AB008) (HPAB-0709-FY)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) (TAB-002LC-F(E))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, SPR
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- Human Anti-CD22 Recombinant Antibody (clone ch5/44) (FAMAB-0048YC)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: ELISA
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- Rat Anti-CD22 Recombinant Antibody (clone 2D6) (NEUT-315CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG1, κ
- Application: Block
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- Mouse Anti-CD22 Recombinant Antibody (clone 5LB129) (MOB-0349MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Mouse Anti-CD22 Recombinant Antibody (clone m5/44) (FAMAB-0046YC)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Cyt
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- Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) (TAB-1729CL-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: IF, FC
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- Human Anti-CD22 Recombinant Antibody (clone g5/44) (FAMAB-0047YC)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG4
- Application: ELISA, Cyt
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- Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) (TAB-1725CL-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Block, Cyt, ELISA, FuncS
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- Anti-Human CD22 Recombinant Antibody scFv Fragment (VM1000) (TAB-002LC-S(P))
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- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, SPR
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- Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) (TAB-1724CL-F(E))
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: Inhib
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- Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) (TAB-001LC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) (TAB-1724CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Inhib
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- Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1725CL-S(P)) (TAB-1725CL-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Block, Cyt, ELISA, FuncS
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- Human Anti-CD22 Recombinant Antibody (TAB-1715CL) (TAB-1715CL)
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- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1722CL-F(E)) (TAB-1722CL-F(E))
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- Type: Human antibody
- Application: ELISA, FC, FuncS
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- Human Anti-CD22 Recombinant Antibody (TAB-1716CL) (TAB-1716CL)
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- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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- Human Anti-CD22 Recombinant Antibody (TAB-1729CL) (TAB-1729CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: IF, FC
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- Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2) (TAB-0196CL-S(P))
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- Application: ELISA, In vivo
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- Anti-Human CD22 Recombinant Antibody scFv Fragment (hLL2-Cys) (TAB-0197CL-S(P))
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- Application: ELISA, In vivo
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- Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1729CL-S(P)) (TAB-1729CL-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: IF, FC
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- Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) (TAB-001LC-F(E))
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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- Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2) (TAB-0196CL-F(E))
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- Application: ELISA, In vivo
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- Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2-Cys) (TAB-0197CL-F(E))
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- Application: ELISA, In vivo
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1715CL-F(E)) (TAB-1715CL-F(E))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1716CL-F(E)) (TAB-1716CL-F(E))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1717CL-F(E)) (TAB-1717CL-F(E))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1718CL-F(E)) (TAB-1718CL-F(E))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1719CL-F(E)) (TAB-1719CL-F(E))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1720CL-F(E)) (TAB-1720CL-F(E))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1721CL-F(E)) (TAB-1721CL-F(E))
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- Type: Human antibody
- Application: ELISA, FC, FuncS
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- Human Anti-CD22 Recombinant Antibody (TAB-1724CL) (TAB-1724CL)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1, κ
- Application: Inhib
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- Human Anti-CD22 Recombinant Antibody (TAB-1725CL) (TAB-1725CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: Block, Cyt, ELISA, FuncS
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1715CL-S(P)) (TAB-1715CL-S(P))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1716CL-S(P)) (TAB-1716CL-S(P))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1717CL-S(P)) (TAB-1717CL-S(P))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1718CL-S(P)) (TAB-1718CL-S(P))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1719CL-S(P)) (TAB-1719CL-S(P))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1720CL-S(P)) (TAB-1720CL-S(P))
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- Derivation: Human
- Type: Fully human antibody
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1721CL-S(P)) (TAB-1721CL-S(P))
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- Type: Human antibody
- Application: ELISA, FC, FuncS
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- Human Anti-CD22 Recombinant Antibody scFv Fragment (TAB-1722CL-S(P)) (TAB-1722CL-S(P))
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- Type: Human antibody
- Application: ELISA, FC, FuncS
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG1, κ
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
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- Anti-CD22 immunotoxin RFB4 (IgG)-PE (AGTO-G077E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Anti-CD22 immunotoxin RFB4 (IgG)-DT (AGTO-G077D)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- anti-CD22 immunotoxin RFB4 (scFv)-PE (AGTO-L048E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Anti-CD22 immunotoxin RFB4 (IgG)-Gel (AGTO-G077G)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- anti-CD22 immunotoxin RFB4 (scFv)-DT (AGTO-L048D)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Anti-CD22 immunotoxin RFB4 (IgG)-RTA (AGTO-G077R)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- anti-CD22 immunotoxin RFB4 (scFv)-Gel (AGTO-L048G)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Anti-CD22 immunotoxin RFB4 (IgG)-Sap (AGTO-G077S)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1723CL-S(P)) (TAB-1723CL-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Inhib
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- Recombinant Anti-Human CD22 Antibody Fab Fragment (MOB-1248z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, RIA, FuncS
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- Recombinant Anti-Human CD22 Antibody scFv Fragment (MOB-1248z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab' - G2a - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, WB
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- Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1714CL-F(E)) (TAB-1714CL-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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- Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1714CL-S(P)) (TAB-1714CL-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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- Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1723CL-F(E)) (TAB-1723CL-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: Inhib
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- Anti-Human CD22 Recombinant Antibody scFv Fragment (RFB4) (TAB-1728CL-S(P))
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- Application: IF, FC
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- Mouse Anti-Human CD22 Recombinant Antibody Fab Fragment (TAB-003LC-F(E))
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- Application: FC
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- Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0370-FY-S(P)) (HPAB-0370-FY-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
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- anti-CD22 immunotoxin RFB4 (scFv)-RTA (AGTO-L048R)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Anti-Human CD22 Recombinant Antibody Fab Fragment (RFB4) (TAB-1728CL-F(E))
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- Application: IF, FC
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- Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment (TAB-003LC-S(P))
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- Application: FC
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- Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-005LC-F(E)) (TAB-005LC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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- Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-005LC-S(P)) (TAB-005LC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Anti-Human CD22 Recombinant Antibody Fab Fragment (TAB-004LC-F(E))
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- Application: FC
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- Anti-Human CD22 Recombinant Antibody scFv Fragment (TAB-004LC-S(P))
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- Application: FC
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- Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-N0324-YC-F(E)) (HPAB-N0324-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FuncS
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- Mouse Anti-CD22 Recombinant Antibody (TAB-1714CL) (TAB-1714CL)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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- Recombinant Human Anti-CD22 Antibody Fab Fragment (HPAB-0249-FY-F(E))
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- Derivation: Chimeric
- Species Reactivity: Human
- Type: Human Fab
- Application: F
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- Anti-CD22 (Pinatuzumab)-MC-VC-PABC-MMAE ADC (ADC-034LCT)
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- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD22-MC-MMAF ADC (ADC-032LCT)
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- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IP, WB
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- Host Species: Mouse
- Specificity: Human
- Type: Mouse antibody
- Classification: Fab glycosylation
- Glycosylation site: FR1 of VK
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- Anti-CD22-MCC-DM1 ADC (ADC-033LCT)
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- Target: CD22
- Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Anti-CD22 (CR011)-vc-MMAE ADC (RG7593) (ADC-L028)
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- Target: CD22
- Linker: vc (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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- Anti-CD22 (clone 10F4v3)-mc-vc-PABC-MMAE ADC (ADC-195LZY)
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- Target: CD22
- Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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- Targets: CD22 & saporin
- Type: Fab2
- Application: FuncS, Pretargeting system for immunotoxin delivery
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- Anti-CD22 (clone hLL2)-SN-38 ADC (ADC-124CL)
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- Target: CD22
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
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- Anti-CD22 (RFB4)-mcc-DM1 ADC (ADC-028LCT)
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- Target: CD22
- Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Anti-CD22 (10F4)-AcBut-Calicheamicin ADC (ADC-029LCT)
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- Target: CD22
- Linker: AcBut
- Drug: Calicheamicin
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- Anti-CD22-CL2A-SN-38 ADC (ADC-030LCT)
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- Target: CD22
- Linker: CL2A
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
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- Anti-CD22-CL2E-SN-38 ADC (ADC-031LCT)
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- Target: CD22
- Linker: CL2E
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
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- Anti-CD22 (clone hu10F4)-MCC-DM1 ADC (ADC-027LZY)
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- Target: CD22
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Anti-CD22-mc-vc-PABc-MMAE ADC (ADC-033LZY)
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- Target: CD22
- Linker: mc-VC-PABc(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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- Anti-CD22 (clone G5/44)-AcBut-CalichDMH ADC (ADC-003LZY)
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- Target: CD22
- Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
- Drug: CalichDMH
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- Anti-CD22-AcBut-CalichDMH ADC (ADC-006LZY)
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- Target: CD22
- Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
- Drug: CalichDMH
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- Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC (ADC-194LZY)
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- Target: CD22
- Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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For Research Use Only. Not For Clinical Use.
Background
Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome.
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.