CD22 & saporin

Anti-CD22 & saporin Products

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Anti-Human CD22 Recombinant Antibody (TAB-183-F(E)) (TAB-183-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fv - disulfide stabilized
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
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Anti-Human CD22 Recombinant Antibody (TAB-176) (TAB-176)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) (TAB-198)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG4, κ
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Human Anti-CD22 Recombinant Antibody (TAB-1722CL) (TAB-1722CL)
- Type: Human antibody
- Application: ELISA, FC, FuncS
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Anti-Human CD22 Recombinant Antibody (RFB4) (TAB-1728CL)
- Application: IF, FC
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Human Anti-CD22 Recombinant Antibody (HPAB-0199-LSX) (HPAB-0199-LSX)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC
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Human Anti-CD22 Recombinant Antibody (TAB-1717CL) (TAB-1717CL)
- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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Human Anti-CD22 Recombinant Antibody (clone MJ-7) (HPAB-0206-LSX)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, WB
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Human Anti-CD22 Recombinant Antibody (TAB-1719CL) (TAB-1719CL)
- Derivation: Human
- Type: Fully human antibody
- Application: ELISA
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Human Anti-CD22 Recombinant Antibody (TAB-1718CL) (TAB-1718CL)
- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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Anti-Human CD22 Recombinant Antibody (hLL2) (TAB-0196CL)
- Application: Inhib, Cyt, FC, WB
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Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) (TAB-1729CL-F(E))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: IF, FC
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Human Anti-CD22 Recombinant Antibody (clone HuLL2) (HPAB-0205-LSX)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
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Anti-Human CD22 Recombinant Antibody (hLL2-Cys) (TAB-0197CL)
- Application: ELISA, In vivo
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) (TAB-001LC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Anti-Human CD22 Recombinant Antibody scFv Fragment (VM1000) (TAB-002LC-S(P))
- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, SPR
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Human Anti-CD22 Recombinant Antibody (TAB-1729CL) (TAB-1729CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: IF, FC
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Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) (TAB-1724CL-F(E))
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: Inhib
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Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) (TAB-1725CL-F(E))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Block, Cyt, ELISA, FuncS
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Human Anti-CD22 Recombinant Antibody (clone RFB4-PE38) (HPAB-0204-LSX)
- Derivation: Chimeric
- Species Reactivity: Human
- Type: Chimeric IgG
- Application: Cyt, RIA, FuncS, FC, PK, Neut, ELISA
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Mouse Anti-CD22 Recombinant Antibody (HPAB-0201-LSX) (HPAB-0201-LSX)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS, ELISA, WB, FC, RIA
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Human Anti-CD22 Recombinant Antibody (HPAB-0202-LSX) (HPAB-0202-LSX)
- Derivation: Chimeric
- Species Reactivity: Human
- Type: Chimeric IgG
- Application: ELISA, WB, FC, RIA
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Human Anti-CD22 Recombinant Antibody (HPAB-0203-LSX) (HPAB-0203-LSX)
- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus monkey
- Type: Humanized IgG1
- Application: ELISA, WB, FC, RIA, FuncS
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1715CL-F(E)) (TAB-1715CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1716CL-F(E)) (TAB-1716CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1717CL-F(E)) (TAB-1717CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1718CL-F(E)) (TAB-1718CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1719CL-F(E)) (TAB-1719CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1720CL-F(E)) (TAB-1720CL-F(E))
- Derivation: Human
- Type: Fully human antibody
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1721CL-F(E)) (TAB-1721CL-F(E))
- Type: Human antibody
- Application: ELISA, FC, FuncS
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Human Anti-CD22 Recombinant Antibody Fab Fragment (TAB-1722CL-F(E)) (TAB-1722CL-F(E))
- Type: Human antibody
- Application: ELISA, FC, FuncS
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Human Anti-CD22 Recombinant Antibody (TAB-1715CL) (TAB-1715CL)
- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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Human Anti-CD22 Recombinant Antibody (TAB-1716CL) (TAB-1716CL)
- Derivation: Human
- Type: Fully human antibody
- Application: Cyt, FuncS
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Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) (TAB-001LC-F(E))
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) (TAB-002LC-F(E))
- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, SPR
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Human Anti-CD22 Recombinant Antibody (HPAB-0195-LSX) (HPAB-0195-LSX)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: Apop, Cyt, FC, WB, Inhib, FuncS, IF, ELISA
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Mouse Anti-CD22 Recombinant Antibody (HPAB-0196-LSX) (HPAB-0196-LSX)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC, IP, RIA
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Human Anti-CD22 Recombinant Antibody (HPAB-0197-LSX) (HPAB-0197-LSX)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC, FuncS
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Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) (HPAB-0198-LSX)
- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA, WB, IF, FC, SPR
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Human Anti-CD22 Recombinant Antibody (TAB-1724CL) (TAB-1724CL)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1, κ
- Application: Inhib
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Human Anti-CD22 Recombinant Antibody (TAB-1725CL) (TAB-1725CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: Block, Cyt, ELISA, FuncS
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Mouse IgG1, kappa Anti-CD22 Recombinant Antibody (MOB-1248z) (MOB-1248z)
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IF, FC
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Humanized Anti-CD22 Recombinant Antibody (clone Pinatuzumab) (TAB-899)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG1, κ
- Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
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Anti-CD22 immunotoxin RFB4 (IgG)-PE (AGTO-G077E)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD22 immunotoxin RFB4 (IgG)-DT (AGTO-G077D)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD22 immunotoxin RFB4 (IgG)-Gel (AGTO-G077G)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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anti-CD22 immunotoxin RFB4 (scFv)-PE (AGTO-L048E)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD22 immunotoxin RFB4 (scFv)-DT (AGTO-L048D)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD22 immunotoxin RFB4 (scFv)-Gel (AGTO-L048G)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD22 immunotoxin RFB4 (scFv)-RTA (AGTO-L048R)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD22 immunotoxin RFB4 (scFv)-Sap (AGTO-L048S)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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Recombinant Anti-Human CD22 Antibody Fab Fragment (MOB-1248z-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, RIA, FuncS
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Recombinant Anti-Human CD22 Antibody scFv Fragment (MOB-1248z-S(P))
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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Anti-Human CD22 Recombinant Antibody Fab Fragment(Bectumomab) (TAB-047-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab' - G2a - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, WB
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Mouse Anti-CD22 Recombinant Antibody (TAB-1714CL) (TAB-1714CL)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1723CL-F(E)) (TAB-1723CL-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: Inhib
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Anti-Human CD22 Recombinant Antibody Fab Fragment (RFB4) (TAB-1728CL-F(E))
- Application: IF, FC
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Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1714CL-F(E)) (TAB-1714CL-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1714CL-S(P)) (TAB-1714CL-S(P))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0195-LSX-S(P)) (HPAB-0195-LSX-S(P))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment (TAB-003LC-S(P))
- Application: FC
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0196-LSX-S(P)) (HPAB-0196-LSX-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Anti-Human CD22 Recombinant Antibody scFv Fragment (TAB-004LC-S(P))
- Application: FC
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0194-LSX-S(P)) (HPAB-0194-LSX-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Anti-CD22 immunotoxin RFB4 (IgG)-RTA (AGTO-G077R)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0325-YC-S(P)) (HPAB-N0325-YC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0197-LSX-S(P)) (HPAB-0197-LSX-S(P))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-005LC-S(P)) (TAB-005LC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-N0324-YC-S(P)) (HPAB-N0324-YC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0198-LSX-S(P)) (HPAB-0198-LSX-S(P))
- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA, FC
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Anti-CD22 (10F4)-AcBut-Calicheamicin ADC (ADC-029LCT)
- Target: CD22
- Linker: AcBut
- Drug: Calicheamicin
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Anti-CD22 (clone RFB4)-MC-MMAF ADC (ADC-226CL)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD22-CL2A-SN-38 ADC (ADC-030LCT)
- Target: CD22
- Linker: CL2A
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
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Anti-CD22 (clone RFB4)-MC-vc-PAB-MMAE ADC (ADC-227CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC (ADC-228CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD22 (RFB4)-mcc-DM1 ADC (ADC-028LCT)
- Target: CD22
- Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v1)-SMCC-DM1 ADC (ADC-216CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v2)-SMCC-DM1 ADC (ADC-217CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v2)-MC-MMAF ADC (ADC-218CL)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD22 (clone 10F4v3)-SMCC-DM1 ADC (ADC-219CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v3)-MC-MMAF ADC (ADC-220CL)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-221CL)
- Target: CD22
- Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC (ADC-222CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD22 (clone 10F4)-SMCC-DM1 ADC (ADC-223CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone RFB4)-SMCC-DM1 ADC (ADC-224CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone RFB4)-MC-vc-PAB-MMAF ADC (ADC-225CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAF (Monomethyl auristatin F)
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Recombinant Anti-CD22 × Anti-saporin Bispecific Antibody (Fab₂) (FAB-L077)
- Targets: CD22 & saporin
- Type: Fab₂
- Application: FuncS, Pretargeting system for immunotoxin delivery
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Anti-CD22 (clone 10F4v3)-BMPEO-DM1 ADC (ADC-211CL)
- Target: CD22
- Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22 (clone 10F4v3)-MC-MMAF ADC (ADC-212CL)
- Target: CD22
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD22 (clone 10F4v3)-MC-vc-PAB-MMAE ADC (ADC-213CL)
- Target: CD22
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
Compare

Anti-CD22 (clone 5E8)-SMCC-DM1 ADC (ADC-214CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
Compare

Anti-CD22 (clone 7A2)-SMCC-DM1 ADC (ADC-215CL)
- Target: CD22
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-CD22-mc-vc-PABc-NMS249 ADC (ADC-097LZY)
- Target: CD22
- Linker: mc-VC-PABc (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: NMS249
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Anti-CD22 (clone G5/44)-AcBut-CalichDMH ADC (ADC-003LZY)
- Target: CD22
- Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
- Drug: CalichDMH
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Anti-CD22-AcBut-CalichDMH ADC (ADC-006LZY)
- Target: CD22
- Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
- Drug: CalichDMH
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Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC (ADC-194LZY)
- Target: CD22
- Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Compare

Anti-CD22 (clone 10F4v3)-mc-vc-PABC-MMAE ADC (ADC-195LZY)
- Target: CD22
- Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
Compare

Anti-CD22 (clone HB22.7)-saporin ADC (ADC-154LZY)
- Target: CD22
- Drug: saporin
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Anti-CD22 (Inotuzumab)-calicheamicin ADC (CMC-544/inotuzumab ozogamicin) (ADC-L024)
- Target: CD22
- Linker: acetyl butyrate linker
- Drug: calicheamicin
Compare

Anti-CD22 (CR011)-vc-MMAE ADC (RG7593) (ADC-L028)
- Target: CD22
- Linker: vc (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
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For Research Use Only. Not For Clinical Use.

Background

Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.

Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome.