Recombinant Mouse Anti-HCV E2 Antibody (mAb#8) (CAT#: PABZ-180)
Recombinant Mouse Antibody (mAb#8) is capable of binding to HCV E2, expressed in Chinese Hamster Ovary cells (CHO). Antibody interactions with two primary anchor sites of epitope II, i.e., the hydrophobic interactions with residues Trp437 Leu438 in the α-helix and the hydrophilic interactions with residues Glu431/Asn434 in the extended loop, contributing to the binding affinity.
Specific Inquiry
SPR
Figure 5 Surface plasmon resonance runs showing the interaction of the recombinant ectoplasmic region of AMA1 as analyte and IgG F8.12.19 covalently immobilised on the Biacore sensor chip.
The runs were corrected for non-specific binding by subtraction of the curves obtained by passage of the same protein solution through a blank channel (no immobilised IgG) on the same senor chip. The curves labelled buffer show the results for passage of the running buffer alone. Analyte was injected for 60 s for the association phase. This was followed by injection of the running buffer alone at the same flow-rate to give the dissociation phase. The response in resonance units (RU) is plotted as a function of time (in s.). PfAMA1 at concentrations 50 μg/ml, 25 μg/ml, 12.5 μg/ml and 6.2 μg/ml, as indicated.
Igonet, S., Vulliez-Le Normand, B., Faure, G., Riottot, M. M., Kocken, C. H., Thomas, A. W., & Bentley, G. A. (2007). Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation. Journal of molecular biology, 366(5), 1523-1537.
Specifications
- Immunogen
- HCV glycoprotein E2
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native HCV E2
- Species Reactivity
- HCV
- Clone
- mAb#8
- Applications
- Can be useful in applications such as: Neutralization
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- E2; glycoprotein E2
- UniProt ID
- F5BWY6
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-040 | Recombinant Mouse Anti-CHIKV E2 glycoprotein Antibody (5F-10) | IF, Neut, IP | IgG |
| PABL-357 | Recombinant Human Anti-VEEV E2 Antibody (F5) | WB, ELISA, Neut, FuncS | IgG |
| PABL-465 | Recombinant Mouse Anti-Epitope II of HCV E2 Antibody (mAb 12) | WB, FuncS | IgG |
| PABL-505 | Recombinant Rat Anti-HCV E2 antigenic region 412-423 Antibody (311) | Neut | IgG |
| HPAB-2105-FY | Human Anti-E2 Recombinant Antibody (clone D12) | ELISA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-118 | Recombinant Rat Anti-HCV E2 Antibody scFv Fragment (3/11) | WB, ELISA, Neut, FuncS | scFv |
| PSBL-119 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment (HC33.1) | Neut, FuncS | scFv |
| PSBL-120 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment (HC84-1) | WB, ELISA, Neut, FuncS | scFv |
| PSBL-121 | Recombinant Mouse Anti-HCV E2 Antibody scFv Fragment (HC84-27) | Neut, FuncS | scFv |
| PSBL-122 | Recombinant Mouse Anti-HCV E2 Antibody scFv Fragment (mAb12) | WB, ELISA, FuncS | scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-119 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (HC33.1) | Neut, FuncS | Fab |
| PFBL-120 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (HC84-1) | WB, ELISA, Neut, FuncS | Fab |
| PFBL-121 | Recombinant Mouse Anti-HCV E2 Antibody Fab Fragment (HC84-27) | Neut, FuncS | Fab |
| PFBL-122 | Recombinant Mouse Anti-HCV E2 Antibody Fab Fragment (mAb12) | WB, ELISA, FuncS | Fab |
| PFBL-123 | Recombinant Mouse Anti-HCV E2 Antibody Fab Fragment (mAb8) | WB, Neut, FuncS | Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-019 | Recombinant Anti-HCV E2 VHH Single Domain Antibody (D03) | Inhib, FuncS | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-020CT | Human Anti-HCV E2 Recombinant Antibody (AP33) | ELISA, IP, Neut, FC, WB | Human antibody |
| TAB-238CT | Anti-HCV E2 Recombinant Antibody (Y47F) | ELISA, WB | Human antibody |
| TAB-239CT | Anti-HCV E2 Recombinant Antibody (Y47W) | ELISA, WB | Human antibody |
| TAB-238CT-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (Y47F) | ELISA, WB | Human antibody |
| TAB-239CT-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (Y47W) | ELISA, WB | Human antibody |
MHC Tetramer for Virology
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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