Recombinant Human Anti-VEEV E2 Antibody (F5) (CAT#: PABL-357)
Recombinant Human Antibody (F5) is capable of binding to VEEV E2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-VEEV E2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-VEEV E2 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Figure 1 Immunohistochemistry of Venezuelan equine encephalitis virus-infected mouse brains.
Virus antigen were detected in neurons from all areas of the CNS examined in an untreated mouse harvested at 5 days post-infection (PI) (A) or a mouse treated with hMAb F5 nIgG 24 h PI (B).
Hunt, A. R., Bowen, R. A., Frederickson, S., Maruyama, T., Roehrig, J. T., & Blair, C. D. (2011). Treatment of mice with human monoclonal antibody 24 h after lethal aerosol challenge with virulent Venezuelan equine encephalitis virus prevents disease but not infection. Virology, 414(2), 146-152.
Specifications
- Immunogen
- VEEV E2 envelop protein
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native VEEV E2
- Species Reactivity
- VEEV
- Clone
- F5
- Applications
- WB Assay-depended
ELISA Assay-depended
Neut Assay-depended
IHC Assay-depended
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- E2 envelop protein; E2; envelop
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-040 | Recombinant Mouse Anti-CHIKV E2 glycoprotein Antibody scFv Fragment (PSBL-040) | Neut, FuncS | scFv |
| PSBL-357 | Recombinant Human Anti-VEEV E2 Antibody scFv Fragment (F5) | WB, ELISA, Neut, FuncS | scFv |
| PFBZ-180 | Recombinant Mouse Anti-HCV E2 Antibody Fab Fragment (mAb#8) | Neut | Fab |
| PFBZ-181 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (hu5B3.v3) | ELISA, Neut | Fab |
| PSBL-462 | Recombinant Mouse Anti-Epitope II of HCV E2 Antibody scFv Fragment (mAb 12) | WB, FuncS | scFv |
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