Recombinant Human Anti-VEEV E2 Antibody (F5) (CAT#: PABL-357)

Recombinant Human Antibody (F5) is capable of binding to VEEV E2, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-VEEV E2 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-VEEV E2 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.


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Figure 1 Immunohistochemistry of Venezuelan equine encephalitis virus-infected mouse brains.

Figure 1 Immunohistochemistry of Venezuelan equine encephalitis virus-infected mouse brains.

Virus antigen were detected in neurons from all areas of the CNS examined in an untreated mouse harvested at 5 days post-infection (PI) (A) or a mouse treated with hMAb F5 nIgG 24 h PI (B).

Hunt, A. R., Bowen, R. A., Frederickson, S., Maruyama, T., Roehrig, J. T., & Blair, C. D. (2011). Treatment of mice with human monoclonal antibody 24 h after lethal aerosol challenge with virulent Venezuelan equine encephalitis virus prevents disease but not infection. Virology, 414(2), 146-152.


Specifications

  • Immunogen
  • VEEV E2 envelop protein
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG
  • Specificity
  • Tested positive against native VEEV E2
  • Species Reactivity
  • VEEV
  • Clone
  • F5
  • Applications
  • WB Assay-depended
    ELISA Assay-depended
    Neut Assay-depended
    IHC Assay-depended

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • Assay-depended

Target

  • Alternative Names
  • E2 envelop protein; E2; envelop

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Single-domain Antibody

CAT Product Name Application Type
PNBL-019 Recombinant Anti-HCV E2 VHH Single Domain Antibody (D03) Inhib, FuncS Llama VHH

Human Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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