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    FOLR1 & CD3

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    Anti-FOLR1 & CD3 ProductsBackground

    Anti-FOLR1 & CD3 Products

    • Anti-FRα (clone M9346A)-SPDB-DM4 ADC (ADC-073LZY)
      • Target: FRα
      • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
      • Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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    • Anti-FRα-DGN462 ADC (ADC-120LZY)
      • Target: FRα
      • Linker: maleimide containing linkers
      • Drug: DGN462
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    • Anti-FR-S-S-Dox ADC (ADC-170LZY)
      • Target: folate receptor (FR)
      • Linker: disulfide ("S-S") linker
      • Drug: doxorubicin
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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency.
    The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
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