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KLF4
Loading...Anti-KLF4 Products
- Rabbit Anti-KLF4 Polyclonal Antibody (MRO-1997-CN) (MRO-1997-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Mouse Anti-KLF4 Recombinant Antibody (VS3-CJ149) (VS3-CJ149)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: WB
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- Mouse Anti-KLF4 Recombinant Antibody (clone 1E5) (VS3-XY980)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
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- AbPlus™ Anti-KLF4 Magnetic Beads (VS-0724-YC96) (VS-0724-YC96)
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- Target: KLF4
- Target Species: Human, Mouse
- Application: IP, Protein Purification
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC
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- Rabbit Anti-KLF4 Recombinant Antibody (VS13-YC626) (VS13-YC626)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC-P
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- Mouse Anti-KLF4 Monoclonal Antibody (VS7-0425-WR228) (VS7-0425-WR228)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC-P, IF, ICC, ELISA
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- Anti-KLF4 Immunohistochemistry Kit (VS-0525-XY3795)
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- Species Reactivity: Human
- Target: KLF4
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Protein class
Cancer-related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Basal squamous epithelial cells, Distal enterocytes, Intestinal goblet cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte, intermediate monocyte)
Cell line specificity
Cell line enhanced (ASC TERT1, hTCEpi, hTERT-HME1, OE19, U-2197)
Interaction
Interacts with POU5F1/OCT4 and SOX2 (By similarity). Interacts with MUC1 (via the C-terminal domain) (PubMed:17308127). Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a (PubMed:21746878). Interacts with ZNF296 (By similarity). Interacts with GLIS1 (PubMed:21654807). Interacts with BTRC; this interaction leads to KLF4 ubiquitination and subsequent degradation (By similarity).
Molecular function
Activator, DNA-binding
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