Mouse Anti-TLR2 Recombinant Antibody (VS3-CJ155)
CAT#: VS3-CJ155
This product is a mouse antibody that recognizes TLR2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60231/1551_D10_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HL-60, HSkMC, hTCEpi, NB-4, RPTEC TERT1, RT4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137462-TLR2
❮
❯
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human TLR2
- Species Reactivity
- Human
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A/G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- 0.09% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500-1:1000).
Target
- Alternative Names
- TIL4; CD282; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD antigen CD282
- Gene ID
- 7097
- UniProt ID
- O60603
- Sequence Similarities
- Belongs to the Toll-like receptor family.
- Cellular Localization
- Cytoplasmic vesicle, Membrane
- Post Translation Modifications
- Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
- Protein Refseq
- NP_001305716.1; NP_001305718.1; NP_001305719.1
- Function
- Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651).
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996).
Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107).
Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205).
MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205).
Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712).
M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303).
Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity).
Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211).
Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS3-CJ155. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
NLR Signaling Pathway
TLR Signaling Pathway
Related Diseases
Rheumatoid Arthritis
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "TLR2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B030(A) | Recombinant Anti-TLR2 Intrabody [(D-Arg)9] | ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B030(G) | Recombinant Anti-TLR2 Intrabody [+36 GFP] | ELISA, WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B030(T) | Recombinant Anti-TLR2 Intrabody [Tat] | IF, FC, WB, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0271MC | Rabbit Anti-TLR2 Antibody | WB | |
| MOB-2351MZ | Recombinant Mouse Anti-Human TLR2 Antibody (clone 22H8) | ELISA, FC, IP | Mouse antibody |
| HPAB-0052-YC | Human Anti-TLR2 Recombinant Antibody (HPAB-0052-YC) | Neut | Humanized IgG |
| MRO-1501-CN | Rabbit Anti-TLR2 Recombinant Antibody (clone JM22-41) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY1457 | Recombinant Rabbit Anti-Tlr2 Antibody (clone R06-8B6) | WB, IHC-Fr, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268CQ | Mouse Anti-TLR2 Recombinant Antibody (TAB-268CQ) | FC, IHC, IF, WB | Mouse IgG1, κ |
| TAB-268CQ-S(P) | Mouse Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-268CQ-S(P)) | ELISA, FC, WB, IP | Mouse scFv |
| TAB-268CQ-F(E) | Mouse Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-268CQ-F(E)) | ELISA, FC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-269CQ | Human Anti-TLR2 Recombinant Antibody (TAB-269CQ) | ELISA, FC, FuncS, IP, Inhib | Humanized IgG1, κ |
| TAB-269CQ-S(P) | Human Anti-TLR2 Recombinant Antibody; scFv Fragment (TAB-269CQ-S(P)) | ELISA, FC, WB, IP | Humanized scFv |
| TAB-269CQ-F(E) | Human Anti-TLR2 Recombinant Antibody; Fab Fragment (TAB-269CQ-F(E)) | ELISA, FC, WB, IP | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0588MZ | Chicken Anti-TLR2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2031CQ | Mouse Anti-TLR2 Recombinant Antibody (clone TL2.1) | FC, IP, Block, IHC, WB | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2032CQ | Mouse Anti-Tlr2 Recombinant Antibody (NEUT-2032CQ) | Neut | Mouse IgG2a |
| NEUT-2033CQ | Human Anti-TLR2 Recombinant Antibody (NEUT-2033CQ) | Neut, FC | Human IgA2 |
| NEUT-2034CQ | Mouse Anti-TLR2 Recombinant Antibody (clone CBL627) | FC, CyTOF, Neut | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3585 | Rabbit Anti-TLR2 Recombinant Antibody (clone DS3585AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-YC-S(P) | Human Anti-TLR2 Recombinant Antibody; scFv Fragment (HPAB-0052-YC-S(P)) | Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0052-YC-F(E) | Human Anti-TLR2 Recombinant Antibody; Fab Fragment (HPAB-0052-YC-F(E)) | Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY254 | AbPlus™ Anti-TLR2 Magnetic Beads (VS-0424-XY254) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY212 | CytoStream™ Mouse Anti-TLR2 Recombinant Antibody (clone 11G7) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY29 | Human Anti-TLR2 scFv-Fc Chimera (VS-0425-FY29) | FC, Inhib, ELISA | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC654 | Recombinant Anti-TLR2 Vesicular Antibody, EV Displayed (VS-0425-YC654) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7301 | Anti-TLR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7302 | Anti-Human TLR2 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: ELISA, SPR, Inhib, FuncS
Application: ELISA, FC, WB, Block
Application: WB, IHC, ELISA, FC
Application: WB, ELISA, IF, FuncS, Apop, BA
Application: FC, IHC-Fr, IP, ELISA, Block
Application: ELISA, IHC, FC, IP, IF, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
