Anti-CD20 (1F5) Fab-HPMA ADC (CAT#: ADC-025LCT)

This ADC product is composed of an anti-CD20 Fab (clone 1F5) conjuagated via a HPMA linker to (1F5 Fab-HPMA). It has demonstrated a response in CD20+ B-lymphoma treatment.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Fab′ fragments of Murine monoclonal Antibody (MoAb) 1F5 (Anti-CD20)
  • Clone
  • 1F5
  • Linker
  • N-(2-Hydroxypropyl)methacrylamide (HPMA)
  • Linker Class/Description
  • Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

Target

  • Introduction
  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;

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Recombinant Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-1633CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (ch1F5) FC Chimeric antibody (mouse/human)
TAB-1634CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (ch1F5-DXL) FC, Apop, CDC, ADCC, Inhib Chimeric antibody (mouse/human)
TAB-1656CL-F(E) Anti-Human MS4A1 Recombinant Antibody Fab Fragment (ch2B8) FC, CMCD, ADCC, Activ, Inhib, Depletion Chimeric antibody (mouse/human)
PABX-026 Recombinant Human Anti-CD20 Antibody (C2H7) FuncS IgG
PABX-026-F (E) Recombinant Mouse Anti-CD20 Antibody Fab Fragment (C2H7) WB, ELISA, FuncS Fab

Hyper-galactosylated

High-mannose Glycoform

CAT Product Name Application Type
Gly-155LC-1 Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Humanized antibody

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-171LC Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) ELISA Chimeric antibody (mouse/human)

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1751CQ Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) Neut, FuncS Mouse IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-772 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocrelizumab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-016 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Rituximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-028 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ofatumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-207 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ublituximab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody
AFC-TAB-771 Afuco™ Anti-MS4A1 ADCC Recombinant Antibody (Ocaratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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