Anti-CD20 (1F5) Fab-HPMA ADC

Name: Anti-CD20 (1F5) Fab-HPMA ADC
SKU: ADC-025LCT
Rating: 5 (1 reviews)

CAT#: ADC-025LCT

This ADC product is composed of an anti-CD20 Fab (clone 1F5) conjuagated via a HPMA linker to (1F5 Fab-HPMA). It has demonstrated a response in CD20+ B-lymphoma treatment.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line REH

Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg

Normal Tissue Figure 4 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg

Normal Tissue Figure 5 Bone marrow

Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg

Normal Tissue Figure 6 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1

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Specifications

Antibody Overview
Fab′ fragments of Murine monoclonal Antibody (MoAb) 1F5 (Anti-CD20)

Clone
1F5

Linker
N-(2-Hydroxypropyl)methacrylamide (HPMA)

Linker Class/Description
Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

Target

Introduction
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;

Gene ID
931

UniProt ID
A0A024R507

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Datasheet

Datasheet - ADC-025LCT.pdf

MSDS

MSDS - ADC-025LCT.pdf

COA

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Product Name

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TAB-1670CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1670CL-F(E))	CDC	Chimeric (mouse/human) Fab
TAB-1671CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1671CL-F(E))	CDC	Chimeric (mouse/human) Fab
TAB-1675CL-F(E)	Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1675CL-F(E))	ELISA, WB	Chimeric (mouse/human) Fab
TAB-1692CL-F(E)	Anti-Human MS4A1 Recombinant Antibody Fab Fragment (Zytux)	ELISA, WB	Chimeric antibody (mouse/human)

CAT	Product Name	Application
TAB-1632CL	Anti-Human MS4A1 Recombinant Antibody (1F5)	FC
TAB-1657CL	Mouse Anti-MS4A1 Recombinant Antibody (TAB-1657CL)	Apop, FuncS
TAB-1658CL	Mouse Anti-MS4A1 Recombinant Antibody (TAB-1658CL)	Apop, FuncS
TAB-1659CL	Mouse Anti-MS4A1 Recombinant Antibody (TAB-1659CL)	Apop, FuncS
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CAT	Product Name	Application	Type
TAB-1635CL	Anti-Human MS4A1 Recombinant Antibody (BVX20)	Inhib	Humanized antibody
TAB-1636CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL)	ADCC, CDC	Humanized IgG
TAB-1637CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL)	ADCC, CDC	Humanized IgG
TAB-1638CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL)	ADCC, CDC	Humanized IgG
TAB-1639CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL)	ADCC, CDC, Apop	Humanized IgG

CAT	Product Name	Application	Type
TAB-1645CL	Anti-Human MS4A1 Recombinant Antibody (2.1.2)	Cyt, FuncS	Fully human antibody
TAB-1646CL	Anti-Human MS4A1 Recombinant Antibody (1.1.2)	Cyt, FuncS	Fully human antibody
TAB-1647CL	Anti-Human MS4A1 Recombinant Antibody (1.5.3)	Cyt, FuncS	Fully human antibody
TAB-1648CL	Anti-MS4A1 Recombinant Antibody (MEDI-552)	Inhib
TAB-1654CL	Human Anti-MS4A1 Recombinant Antibody (TAB-1654CL)	FC, Apop	Human IgG1, κ

CAT	Product Name	Application	Type
Gly-059LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-063LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-097LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Chimeric antibody (mouse/human)
Gly-115LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation)	ELISA	Humanized antibody
Gly-138LC	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-063LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-135LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-136LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-137LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody
Gly-138LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-142LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-155LC-1	Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-171LC	Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application
MHC-LC066	PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC067	APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC068	BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer	FCM
MHC-LC4347	PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer	FCM

CAT	Product Name	Application	Type
NEUT-1751CQ	Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211)	Neut, FuncS	Mouse IgG1, κ

CAT	Product Name	Application	Type
MOR-2295	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB)	IHC-Fr, IHC-P	Rabbit IgG
MOR-4024	Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0018-FY	Human Anti-MS4A1 Recombinant Antibody (HPAB-0018-FY)	FC	Humanized IgG1
HPAB-0021-FY	Human Anti-MS4A1 Recombinant Antibody (HPAB-0021-FY)	FC	Humanized IgG
HPAB-0742-CN	Human Anti-MS4A1 Recombinant Antibody (HPAB-0742-CN)	ELISA, FC	Human IgG
HPAB-0743-CN	Human Anti-MS4A1 Recombinant Antibody (HPAB-0743-CN)	ELISA, FC	Human IgG
HPAB-0744-CN	Human Anti-MS4A1 Recombinant Antibody (HPAB-0744-CN)	ELISA, FC	Human IgG

CAT	Product Name	Application	Type
HPAB-0261CQ-S(P)	Mouse Anti-MS4A1 Recombinant Antibody (clone CBM502); scFv Fragment	ELISA, FC, FuncS	Mouse scFv
HPAB-0262CQ-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-0262CQ-S(P))	ELISA, FC	Human scFv
HPAB-0264CQ-S(P)	Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-0264CQ-S(P))	ELISA, FC	Human scFv
HPAB-1693LY-S(P)	Mouse Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-1693LY-S(P))	Neut, FC, IHC-Fr, IHC-P, IP	Mouse scfv
HPAB-1694LY-S(P)	Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-1694LY-S(P))	Inhib	Humanized scfv

CAT	Product Name	Application	Type
HPAB-M0704-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0704-YC)	ELISA, FuncS	Camelid VHH
HPAB-M0705-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0705-YC)	ELISA	Camelid VHH
HPAB-M0706-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC)	ELISA	Camelid VHH
HPAB-M0707-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC)	ELISA	Camelid VHH
HPAB-M0708-YC	Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0708-YC)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
AFC-TAB-772	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-016	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-028	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
AFC-TAB-207	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-771	Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-0614-WJ-F(E)	Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0614-WJ-F(E))	ELISA, FC	Mouse Fab
HPAB-0615-WJ-F(E)	Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0615-WJ-F(E))	ELISA, FC	Mouse Fab
HPAB-0616-WJ-F(E)	Mouse Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0616-WJ-F(E))	ELISA, FC	Mouse Fab
HPAB-1321-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-1321-FY-S(P))	FC, ELISA	Human scFv
HPAB-1322-FY-S(P)	Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-1322-FY-S(P))	FC, ELISA	Human scFv

CAT	Product Name	Application	Type
VS-0424-XY188	AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC138	Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced	FC, CDC, IP	Antibody hexamer
VS-0924-YC139	Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced	FC, Activ, Agonist, IF, WB, Cyt, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY85	Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0125-FY30	Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera	FuncS	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY168	CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A)	FC	Rat IgG2a, kappa

CAT	Product Name	Application	Type
VS-0425-YC513	Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY4510	Anti-MS4A1 Immunohistochemistry Kit	IHC
VS-0525-XY4511	Anti-Mouse MS4A1 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC129	Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv	ELISA, FC	Tandem scFv
VS-0525-YC222	Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv	ELISA, IF, WB	Tandem scFv

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