Anti-Human APP Recombinant Antibody Fab Fragment (2B3) (CAT#: TAB-0847CLV-F(E))
The anti-APP antibody specifically binds amyloid precursor protein from which the β-amyloid is cleaved. By binding the APP and therefore reducing the accumulation or the release of β-amyloid, the antibody can be used in the treatment of conditions related with elevated levels of β-amyloid, such as Alzheimer's Disease.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/60_E2_1_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1462/61_E2_1_blue_red_green.jpg
Figure 4 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/157/2073_B_7_5.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142192-APP
Specifications
- Immunogen
- Ka (spanning the β-secretase cleavage site in human APP)
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 2B3
- Related Disease
- Alzheimer's Disease
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0341CL | Mouse Anti-APP Recombinant Antibody (TAB-0341CL) | ELISA, FuncS, In vivo | Mouse IgG |
| TAB-0342CL | Mouse Anti-APP Recombinant Antibody (TAB-0342CL) | ELISA, FuncS, In vivo | Mouse IgG |
| TAB-0764CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0764CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0765CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0765CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0766CLV-S(P) | Mouse Anti-APP Recombinant Antibody; scFv Fragment (TAB-0766CLV-S(P)) | ELISA | Mouse scFv |
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