Recombinant Human Anti-CD20 Antibody (C2H7) (CAT#: PABX-026)
Anti-CD20 antibody is a Chimeric antibody (mouse/human) of IgG1 λ class that binds to an CD20. This antibody can mediate complement dependent cytotoxicity and antibody-dependent cellular cytotoxicity effects on CD20 positive human Burkitt lymphoma cells and the Fab fragment can well recognize and bind to an epitope peptide of the extracellular loop of CD20.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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FuncS
Figure 1 Cytotoxicity assays of C2H7 and Rituximab on Raji cells.
CDC assays with 10% normal human serum as a source of complement and the activities were determined by measuring the amount of released LDH with the CytoTox 96 non-Radioactive Cytotoxicity Assay kit. All experiments were performed in triplicate and the data are presented as mean ±S.D.
Du, J., Wang, H., Zhong, C., Peng, B., Zhang, M., Li, B., ... & Ding, J. (2008). Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide. Molecular immunology, 45(10), 2861-2868.
FuncS
Figure 2 Cytotoxicity assays of C2H7 and Rituximab on Raji cells.
ADCC assays with human peripheral blood mononuclear cells as effectors were performed with respective antibodies on Raji cells and the activities were determined by measuring the amount of released LDH with the CytoTox 96 non-Radioactive Cytotoxicity Assay kit. All experiments were performed in triplicate and the data are presented as mean ±S.D.
Du, J., Wang, H., Zhong, C., Peng, B., Zhang, M., Li, B., ... & Ding, J. (2008). Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide. Molecular immunology, 45(10), 2861-2868.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human CD20
- Species Reactivity
- Human
- Clone
- C2H7
- Applications
- FuncS
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. should be carefully titrated in specific assays.
Target
- Alternative Names
- MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1;
- Gene ID
- 931
- UniProt ID
- P11836
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-207 | Anti-Human CD20 Recombinant Antibody | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-1700CL | Anti-Human MS4A1 Recombinant Antibody (R92-3-1) | ADCC | Chimeric antibody (mouse/human) |
| TAB-1666CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1666CL-S(P)) | CDC | Mouse scFv |
| TAB-1667CL-S(P) | Mouse Anti-MS4A1 Recombinant Antibody; scFv Fragment (TAB-1667CL-S(P)) | CDC | Mouse scFv |
| PABX-026-F (E) | Recombinant Mouse Anti-CD20 Antibody Fab Fragment (C2H7) | WB, ELISA, FuncS | Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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