Anti-CD22 (clone RFB4)-MC-vc-PAB-MMAF ADC (CAT#: ADC-225CL)

• Antibody Overview
• Anti-CD22 Antibody RFB4

• Clone
• RFB4

• Linker
• MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
  CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.

• Alternative Names
• CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;

• Gene ID
• 933

• UniProt ID
• P20273

• AGTO-G077E
• Anti-CD22 immunotoxin RFB4 (IgG)-PE

• AGTO-L048E
• anti-CD22 immunotoxin RFB4 (scFv)-PE

• AGTO-G077D
• Anti-CD22 immunotoxin RFB4 (IgG)-DT

• AGTO-L048D
• anti-CD22 immunotoxin RFB4 (scFv)-DT

• AGTO-G077G
• Anti-CD22 immunotoxin RFB4 (IgG)-Gel

• AGTO-L048G
• anti-CD22 immunotoxin RFB4 (scFv)-Gel

• AGTO-G077R
• Anti-CD22 immunotoxin RFB4 (IgG)-RTA

• AGTO-L048R
• anti-CD22 immunotoxin RFB4 (scFv)-RTA

• AGTO-G077S
• Anti-CD22 immunotoxin RFB4 (IgG)-Sap

• AGTO-L048S
• anti-CD22 immunotoxin RFB4 (scFv)-Sap

• ADC-028LCT
• Anti-CD22 (RFB4)-mcc-DM1 ADC

• ADC-224CL
• Anti-CD22 (clone RFB4)-SMCC-DM1 ADC

• ADC-226CL
• Anti-CD22 (clone RFB4)-MC-MMAF ADC

• ADC-227CL
• Anti-CD22 (clone RFB4)-MC-vc-PAB-MMAE ADC

• TAB-1728CL
• Anti-Human CD22 Recombinant Antibody (RFB4)

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