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    Anti-CD28 Antibody-Cytokine Fusion Protein, IL2-IgG (15E8)

    CAT#: ACFP-SH130

    This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD28 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD28 as well as the biological activity of IL2. In vitro analysis revealed that the IL2-FuP supported mainly proliferation and lymphokine-activated killer cell activity. IL2-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. This immunocytokine was designed for treating tumor.

    Gene Expression
    ❮
    Figure 1 Lymph node Figure 2 Tonsil Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
    ❯

    Specifications

    • Target
    • CD28
    • Molecule Class
    • IL2-IgG2a
    • Species Reactivity
    • Human
    • Expression Host
    • CHO
    • Clone
    • 15E8
    • Related Disease
    • Tumor
    • Cytokine 1
    • IL2
    • Cytokines 1 Description
    • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
    • Cytokine 1 Species
    • Human
    • Applications
    • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

    Target

    • Alternative Names
    • CD28; CD28 molecule; CD28 antigen (Tp44); T-cell-specific surface glycoprotein CD28; T cell specific surface glycoprotein; CD28 antigen; Tp44; MGC138290
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    Related Diseases

    Rheumatoid Arthritis Rheumatoid Arthritis
    Systemic Lupus Erythematosus Systemic Lupus Erythematosus
    Allograft Rejection Allograft Rejection
    Autoimmune Thyroid Disease Autoimmune Thyroid Disease
    Graft-versus-Host Disease Graft-versus-Host Disease
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Datasheet

    Datasheet - ACFP-SH130.pdf

    MSDS

    MSDS - ACFP-SH130.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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    • CAT
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