Anti-CD28 Immunocytokine, TNF-IgG (15E8) (ACFP-SH131)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD28 IgG to TNF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD28 as well as the biological activity of TNF. TNF-FuP provided a weak stimulus for lymphocyte proliferation, but it had no effect on LAK cells. However, it supported activation of Mfs and, to a minor extent, of CTLs. This immunocytokine was designed for treating tumor.
Specifications
- Target
- CD28
- Molecule Class
- TNF-IgG2a
- Species Reactivity
- Human
- Host
- Mouse
- Expression Host
- CHO
- Clone
- 15E8
- Related Disease
- Tumor
- Cytokines 1
- TNF
- Cytokines 1 Description
- Tumor necrosis factor (TNF), formerly known as TNFα or TNF alpha, is the best-known member of this class. TNF is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia. The protein is synthesized as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers. Both the mature protein and a partially processed form of the hormone can be secreted after cleavage of the propeptide.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- CD28; CD28 molecule; CD28 antigen (Tp44); T-cell-specific surface glycoprotein CD28; T cell specific surface glycoprotein; CD28 antigen; Tp44; MGC138290
- Entrez Gene ID
- 940
- UniProt ID
- P31041
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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