Anti-CD4 Antibody-Cytokine Fusion Protein, IL2-IgG (OKT4) (CAT#: ACFP-SH122)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD4 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD4 as well as the biological activity of IL2. IL2-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. The fusion protein supported mainly proliferation and lymphokine-activated killer cell activity. The therapeutic effect was improved by intratumoral application. Importantly, the efficacy of both IL2-FuP depended on the induction of an immune response in vivo. This immunocytokine was designed for treating tumor.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Specifications
- Target
- CD4
- Molecule Class
- IL2-IgG
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- OKT4
- Related Disease
- Tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- CD4; CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Antigen; CD4mut; CD4 Receptor; CD4 Antigen (P55)
- Gene ID
- 920
- UniProt ID
- B4DT49
Related Resources
Primary Immunodeficiency
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Customer Reviews and Q&As
Customer Review
Q&As
Excellent for research
As a research tool, this antibody product has been invaluable, providing the specificity and sensitivity needed for our detailed studies.
Accurate titration
The antibody product allows for accurate titration, enabling us to determine the optimal working concentration for different experiments.
Thorough instructions
The thorough instructions provided with this product have been very helpful, ensuring proper usage and maximizing its effectiveness.
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For Research Use Only. Not For Clinical Use.
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