Anti-CD4 Antibody-Cytokine Fusion Protein, TNF-IgG (OKT4) (CAT#: ACFP-SH123)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD4 IgG to TNF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD4 as well as the biological activity of TNF. TNF-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. The fusion protein stimulated cytokine production and cytotoxic activity of monocytes and, to a low degree, of T cells. The therapeutic effect was improved by intratumoral application. Importantly, the efficacy of TNF-FuP depended on the induction of an immune response in vivo. This immunocytokine was designed for treating tumor.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
RNA Expression

Specifications

  • Target
  • CD4
  • Molecule Class
  • TNF-IgG2b
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • OKT4
  • Related Disease
  • Tumor
  • Cytokine 1
  • TNF
  • Cytokines 1 Description
  • Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, Psoriasis and inflammatory bowel disease (IBD). While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • CD4; CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Antigen; CD4mut; CD4 Receptor; CD4 Antigen (P55)

Related Resources

  • Related Diseases

Downloads

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Human Antibody

CAT Product Name Application Type
TAB-039 Anti-Human CD4 Recombinant Antibody (Zanolimumab) Neut, ELISA, IF, IP, FuncS, FC, IHC IgG1 - kappa

Humanized Antibody

CAT Product Name Application Type
TAB-260 Anti-Human CD4 Recombinant Antibody (Tregalizumab) WB, ELISA, FC, IP, FuncS, IF, Neut IgG1 - kappa
TAB-146 Anti-Human CD4 Recombinant Antibody (Ibalizumab) FuncS, IF, Neut, ELISA, FC, IP, ICC IgG4 - kappa
TAB-161LC Anti-Human CD4 Recombinant Antibody (gOKT4A-4) ELISA Humanized antibody
TAB-168LC Anti-Human CD4 Recombinant Antibody (TRX1) ELISA Humanized antibody
TAB-171LC Human Anti-CD4 Recombinant Antibody (TAB-171LC) ELISA, FC, SPR Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G078E Anti-CD4 immunotoxin M-T151 (IgG)-PE Cytotoxicity assay, Function study
AGTO-G078R Anti-CD4 immunotoxin M-T151 (IgG)-RTA Cytotoxicity assay, Function study

Chimeric Antibody

CAT Product Name Application Type
TAB-162LC-F(E) Anti-Human CD4 Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)
TAB-164LC-F(E) Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-164LC-F(E)) FC, SPR, ELISA Chimeric (macaque/human) Fab
TAB-165LC-F(E) Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-165LC-F(E)) FC, SPR, ELISA Chimeric (macaque/human) Fab
TAB-167LC-F(E) Anti-Human CD4 Recombinant Antibody Fab Fragment (cM-T412) ELISA Chimeric antibody (mouse/human)
TAB-170LC-F(E) Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) ELISA, SPR Chimeric antibody (rat/human)

Fab Glycosylation

CAT Product Name Application Type
Gly-025LC Recombinant Anti-Human CD4 Antibody (Fab glycosylation) ELISA Humanized antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-351CQ Mouse Anti-CD4 Recombinant Antibody (clone 10C12) ELISA, WB, IF, Block Mouse IgG1
NEUT-352CQ Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) Block, ELISA, FC, IHC-Fr, WB Mouse IgG1, κ
NEUT-355CQ Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) FC, CyTOF, Block, IHC Mouse IgG1, κ
NEUT-357CQ Rat Anti-CD4 Recombinant Antibody (clone MAB0810) Block, Depletion, Stim Rat IgG2b
NEUT-358CQ Rat Anti-CD4 Recombinant Antibody (clone RM4-5) FC, CyTOF, Depletion, Block, IHC Rat IgG2a, κ

Neutralizing Antibody

CAT Product Name Application Type
NEUT-353CQ Mouse Anti-CD4 Recombinant Antibody (clone CBL976) FC, Neut, IF, IHC Mouse IgG1, κ
NEUT-354CQ Recombinant Mouse Anti-CD4 Antibody (CT-4) Neut, FC, IHC, IHC-Fr, IHC-P, IP IgG1, κ
NEUT-356CQ Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) Neut, FC, IHC, IHC-Fr, IP, ICC Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0560 Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) IHC-P Rabbit IgG

Recombinant Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-039 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-164 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-260 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF ADCC enhanced antibody
AFC-TAB-171 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-107 Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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