This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD4 IgG to TNF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD4 as well as the biological activity of TNF. TNF-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. The fusion protein stimulated cytokine production and cytotoxic activity of monocytes and, to a low degree, of T cells. The therapeutic effect was improved by intratumoral application. Importantly, the efficacy of TNF-FuP depended on the induction of an immune response in vivo. This immunocytokine was designed for treating tumor.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-260 | Anti-Human CD4 Recombinant Antibody (Tregalizumab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - kappa |
TAB-146 | Anti-Human CD4 Recombinant Antibody (Ibalizumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG4 - kappa |
TAB-161LC | Anti-Human CD4 Recombinant Antibody (gOKT4A-4) | ELISA | Humanized antibody |
TAB-168LC | Anti-Human CD4 Recombinant Antibody (TRX1) | ELISA | Humanized antibody |
TAB-171LC | Human Anti-CD4 Recombinant Antibody (TAB-171LC) | ELISA, FC, SPR | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-033 | Human Anti-CD4 Recombinant Antibody (clone 17b); scFv Fragment | WB, ELISA, FuncS | Human scFv |
HPAB-0474LY-S(P) | Rat Anti-CD4 Recombinant Antibody (clone CBL006LY); scfv Fragment | WB, FC, ELISA | Rat scfv |
HPAB-0295-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone CBLC-005); scFv Fragment | WB, IHC, FC | Mouse scFv |
HPAB-1110WJ-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone KCLRF-BP-00211); scFv Fragment | FC, IHC | Mouse scFv |
HPAB-2112-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone MT15.1); scFv Fragment | Inhib | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-160LC | Anti-Human CD4 Recombinant Antibody (OKT4A) | ELISA, WB | |
TAB-166LC | Anti-Human CD4 Recombinant Antibody (M-T412) | ELISA, Inhib | |
TAB-173LC | Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) | ELISA, Inhib | |
TAB-175LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (15A7) | FC, ELISA | |
TAB-176LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (14G7) | FC, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-162LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
TAB-164LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-164LC-F(E)) | FC, SPR, ELISA | Chimeric (macaque/human) Fab |
TAB-165LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-165LC-F(E)) | FC, SPR, ELISA | Chimeric (macaque/human) Fab |
TAB-167LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (cM-T412) | ELISA | Chimeric antibody (mouse/human) |
TAB-170LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) | ELISA, SPR | Chimeric antibody (rat/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-025LC | Recombinant Anti-Human CD4 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0054-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T310); Fab Fragment | Neut | Mouse Fab |
FAMAB-0055-YC-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone M-T404); Fab Fragment | Neut | Mouse Fab |
FAMAB-0007-CN-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone CT4); Fab Fragment | FC | Mouse Fab |
FAMAB-0008-CN-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone EP96); Fab Fragment | FC | Mouse Fab |
HPAB-2059LY-F(E) | Mouse Anti-CD4 Recombinant Antibody; Fab Fragment (HPAB-2059LY-F(E)) | FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0048CQ | Mouse Anti-CD4 Recombinant Antibody (clone Leu3a) | ELISA, FC, Block, FuncS | Mouse IgG1, κ |
MRO-1750-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1750-CN) | WB, IF, IHC, FC | Rabbit IgG |
MRO-1751-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1751-CN) | WB, IF, IHC, FC | Rabbit IgG |
MRO-1752-CN | Rabbit Anti-CD4 Polyclonal Antibody (MRO-1752-CN) | WB, IF, IHC, FC | Rabbit IgG |
HPAB-0557-WJ | Human Anti-CD4 Recombinant Antibody (clone TRX1) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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