Anti-Human CA-125 Recombinant Antibody (Abagovomab) (CAT#: TAB-114)
Recombinant monoclonal antibody to CA-125. Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA-125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cervix
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg
(Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65600/166228_B_7_3.jpg
Figure 2 RNA cell line category: Group enriched (A-431, HeLa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
Figure 2 RNA cell line category: Group enriched (A-431, HeLa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000181143-MUC16
Specifications
- Immunogen
- CA-125 purified from human ovarian carcinoma.
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
- CAS
- 792921-10-9
- Generic Name
- Abagovomab
- UNII
- 3YK0326U7X
- Related Disease
- Ovarian cancers
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- Abagovomab;792921-10-9;OC125;ACA125;clone 3D5;MUC16;mucin 16, cell surface associated;mucin-16;CA125;FLJ14303;CA-125;MUC-16;CA125 ovarian cancer antigen;ovarian carcinoma antigen CA125;ovarian cancer-related tumor marker CA125;
- Gene ID
- 94025
- UniProt ID
- Q8WXI7
Related Resources
Please refer to Abagovomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Abagovomab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Abagovomab"
Afuco™ Anti-MUC16 ADCC Recombinant Antibody (Abagovomab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CA-125. Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA-125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.
See other products for "MUC16"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1301z | Mouse Anti-MUC16 Recombinant Antibody (clone 21C12) | WB, ELISA, IHC | Mouse IgG |
| HPAB-0310-YC | Mouse Anti-MUC16 Recombinant Antibody (HPAB-0310-YC) | ELISA, FC, IHC, FuncS | Mouse IgG |
| MRO-1040-CN | Recombinant Rabbit Anti-MUC16 Monoclonal Antibody (CBACN-386) | WB, IF, FC | Rabbit IgG |
| MRO-1041-CN | Recombinant Rabbit Anti-MUC16 Monoclonal Antibody (CBACN-387) | WB, IF, FC | Rabbit IgG |
| HPAB-N0185-YC | Human Anti-MUC16 Recombinant Antibody (HPAB-N0185-YC) | FuncS | Humanized IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H63 | Humanized Anti-MUC16 Recombinant V-kappa Antibody (clone Sofituzumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | Humanized IgG1, κ |
| TAB-1397CL | Human Anti-MUC16 Recombinant Antibody (TAB-1397CL) | FuncS | Humanized IgG |
| TAB-1399CL | Human Anti-MUC16 Recombinant Antibody (TAB-1399CL) | FuncS | Humanized IgG |
| TAB-0339CL-S(P) | Human Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-0339CL-S(P)) | DB, WB, IP, ELISA, FC | Humanized scFv |
| TAB-1397CL-F(E) | Human Anti-MUC16 Recombinant Antibody; Fab Fragment (TAB-1397CL-F(E)) | FuncS | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-043 | Anti-Human MUC16 Recombinant Antibody F(ab')2 Fragment( Igovomab) | ELISA, FC, IP, FuncS, IF, Neut, IHC | F(ab')2 - G1 |
| TAB-1401CL | Anti-Human MUC16 Recombinant Antibody (OC125) | IF, IHC, IP, FC | |
| TAB-1402CL | Anti-Human MUC16 Recombinant Antibody (VK-8) | IF, FC | |
| TAB-1401CL-F(E) | Anti-Human MUC16 Recombinant Antibody Fab Fragment (OC125) | IF, IHC, IP, FC | |
| TAB-1402CL-F(E) | Anti-Human MUC16 Recombinant Antibody Fab Fragment (VK-8) | IF, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1398CL | Human Anti-MUC16 Recombinant Antibody (TAB-1398CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1400CL | Human Anti-MUC16 Recombinant Antibody (TAB-1400CL) | FuncS | Chimeric (mouse/human) IgG |
| TAB-1398CL-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-1398CL-S(P)) | FuncS | Mouse scFv |
| TAB-1400CL-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (TAB-1400CL-S(P)) | FuncS | Mouse scFv |
| TAB-1398CL-F(E) | Human Anti-MUC16 Recombinant Antibody; Fab Fragment (TAB-1398CL-F(E)) | FuncS | Chimeric (mouse/human) Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2321 | Hi-Affi™ Recombinant Rabbit Anti-MUC16 Monoclonal Antibody (DS2321AB) | ICC, IHC-P, WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0310-YC-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-0310-YC-F(E)) | ELISA, FC, IHC, FuncS | Mouse Fab |
| HPAB-1114LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-1114LY-F(E)) | ELISA | Mouse Fab |
| HPAB-1115LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-1115LY-F(E)) | ELISA | Mouse Fab |
| HPAB-1116LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-1116LY-F(E)) | ELISA | Mouse Fab |
| HPAB-1117LY-F(E) | Mouse Anti-MUC16 Recombinant Antibody; Fab Fragment (HPAB-1117LY-F(E)) | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1114LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1114LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1115LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1115LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1116LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1116LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1117LY-S(P) | Mouse Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-1117LY-S(P)) | ELISA | Mouse scfv |
| HPAB-N0185-YC-S(P) | Human Anti-MUC16 Recombinant Antibody; scFv Fragment (HPAB-N0185-YC-S(P)) | FuncS | Humanized scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-114 | Afuco™ Anti-MUC16 ADCC Recombinant Antibody (Abagovomab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-H63 | Afuco™ Anti-MUC16 ADCC Recombinant Antibody (Sofituzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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