Afuco™ Anti-Human IFNG ADCC Recombinant Antibody (NI-0501), ADCC Enhanced (CAT#: AFC-365CL)
Anti-IFNG ADCC Enhanced Antibody (NI-0501) is an ADCC enhanced antibody produced by our Afuco™ platform. NI-0501 is a fully human monoclonal antibody that neutralizes interferon gamma, a cell-signaling protein believed to play a pivotal role in the development of HLH. In the ongoing Phase II study, NI-0501 was initially administered to patients showing unsatisfactory response or intolerance to conventional therapies including chemotherapy, immune-suppressive medicines, and immune-depleting drugs. The approved amendment to the protocol allows NI-0501 to be administered to patients as a first-line treatment before any other intervention.
Specific Inquiry
Figure 1 NI-0501 treatment significantly improved parameters of HLH disease activity.
Allen, C., De Benedetti, F., Grom, A. A., Ballabio, M., Ferlin, W. G., De Min, C., & NI-0501-04 Study Group. (2015). A novel targeted approach to the treatment of hemophagocytic lymphohistiocytosis (HLH) with an anti-interferon gamma (IFNγ) monoclonal antibody (mAb), NI-0501: first results from a pilot phase 2 study in children with primary HLH.
Figure 2 CXCL9 levels tightly correlated with IFNγ production, estimated by measuring IFNγ bound to NI-0501.
Allen, C., De Benedetti, F., Grom, A. A., Ballabio, M., Ferlin, W. G., De Min, C., & NI-0501-04 Study Group. (2015). A novel targeted approach to the treatment of hemophagocytic lymphohistiocytosis (HLH) with an anti-interferon gamma (IFNγ) monoclonal antibody (mAb), NI-0501: first results from a pilot phase 2 study in children with primary HLH.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Autoimmune Diseases; Inflammatory Diseases
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- 4°C or -20°C, avoid repeated freezing and thawing.
Target
- Alternative Names
- IFNG; interferon, gamma; IFG; IFI; interferon gamma; IFN-gamma; immune interferon
- Gene ID
- 3458
- UniProt ID
- P01579
Related Resources
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Primary Immunodeficiency
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IFNG"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-090 | Recombinant Anti-human IFNG VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-140CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (BIV 3E) | ELISA | Single domain antibody |
| TAB-141CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (TRI 3E) | ELISA | Single domain antibody |
| TAB-142CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (TETRA 3E) | ELISA | Single domain antibody |
| TAB-143CT | Anti-Human IFN-γ Therapeutic Single Domain Antibody (BIV#m3F) | ELISA | Single domain antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-041 | Anti-Human IFNG Recombinant Antibody (Fontolizumab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 |
| PABX-113 | Recombinant Human Anti-IFN-gamma Antibody (HuZAF) | WB, ELISA, FuncS | IgG |
| PABX-113-F (E) | Recombinant Human Anti-IFN-gamma Antibody Fab Fragment (HuZAF) | WB, ELISA, FuncS | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-229 | Human Anti-IFNG Recombinant Antibody (clone YC118); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0040-YC-S(P) | Human Anti-IFNG Recombinant Antibody; scFv Fragment (HPAB-0040-YC-S(P)) | Neut | Human scFv |
| HPAB-S0067-YC-S(P) | Human Anti-IFNG Recombinant Antibody (clone chAF2); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-S0068-YC-S(P) | Human Anti-IFNG Recombinant Antibody (clone Haf25); scFv Fragment | ELISA, Neut | Humanized scFv |
| HPAB-S0069-YC-S(P) | Human Anti-IFNG Recombinant Antibody (clone HuXAF); scFv Fragment | ELISA, Neut | Humanized scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0289MC | Recombinant Anti-Canine IFN-gamma Antibody. | WB, ELISA |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-112 | Recombinant Human Anti-IFN Antibody (ScFv01) | Neut, FuncS | IgG |
| PABX-112-S (P) | Recombinant Human Anti-IFN Antibody scFv Fragment (ScFv01) | Neut, FuncS | scFv |
| PABX-113-S (P) | Recombinant Human Anti-IFN-gamma Antibody scFv Fragment (HuZAF) | WB, ELISA, FuncS | scFv |
| PABX-112-F (E) | Recombinant Human Anti-IFN Antibody Fab Fragment (ScFv01) | Neut, FuncS | Fab |
| TAB-423CQ | Anti-Human IFNG Recombinant Antibody (Emapalumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, λ1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-992CQ | Mouse Anti-IFNG Recombinant Antibody (clone CBL766) | Neut | Mouse IgG1 |
| NEUT-993CQ | Mouse Anti-IFNG Recombinant Antibody (clone CBL813) | FC, CyTOF, Neut | Mouse IgG2b |
| NEUT-994CQ | Mouse Anti-IFNG Recombinant Antibody (clone 4S.B3) | FC, Neut | Mouse IgG |
| NEUT-995CQ | Mouse Anti-IFNG Recombinant Antibody (clone 7H58) | FC, IHC-Fr, Neut | Mouse IgG2 |
| NEUT-996CQ | Mouse Anti-IFNG Recombinant Antibody (clone CBL201) | ELISA, Neut | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1002CQ | Mouse Anti-IFNG Recombinant Antibody (clone CBL253) | Inhib, IHC, IP | Mouse IgG1 |
| NEUT-1008CQ | Mouse Anti-IFNG Recombinant Antibody (clone B133.5) | Block | Mouse IgG1 |
| NEUT-1013CQ | Mouse Anti-IFNG Recombinant Antibody (clone B-B1) | Block, FC | Mouse IgG1 |
| NEUT-1014CQ | Mouse Anti-IFNG Recombinant Antibody (clone D9D10) | Block, FC, ELISA, WB | Mouse IgG1 |
| NEUT-1033CQ | Mouse Anti-IFNG Recombinant Antibody (clone SN-6) | ELISA, Block | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4228 | Rabbit Anti-IFNG Recombinant Antibody (clone SI307DS) | FC | Rabbit IgG |
| MOR-4229 | Rabbit Anti-IFNG Recombinant Antibody (clone SI308DS) | FC | Rabbit IgG |
| MOR-4600 | Rabbit Anti-IFNG Recombinant Antibody (clone TH113DS) | WB | Rabbit IgG |
| MOR-4601 | Rabbit Anti-IFNG Recombinant Antibody (clone TH114DS) | WB | Rabbit IgG |
| MOR-4602 | Rabbit Anti-Ifng Recombinant Antibody (clone TH115DS) | WB | Rabbit IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0882LC | Mouse Anti-IFNG Recombinant Antibody (clone MIF3009) | ELISA | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0162-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 41ms4G); Fab Fragment | ELISA | Human Fab |
| FAMAB-0163-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 57-5); Fab Fragment | ELISA | Human Fab |
| FAMAB-0164-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 36-4); Fab Fragment | ELISA | Human Fab |
| FAMAB-0165-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 44ms4); Fab Fragment | ELISA | Human Fab |
| FAMAB-0166-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 13ms5F); Fab Fragment | ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-041 | Afuco™ Anti-IFNG ADCC Recombinant Antibody (Fontolizumab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| AFC-TAB-423CQ | Afuco™ Anti-IFNG ADCC Recombinant Antibody (Emapalumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0067-YC | Human Anti-IFNG Recombinant Antibody (clone chAF2) | ELISA, Neut | Chimeric (mouse/human) IgG |
| HPAB-S0068-YC | Human Anti-IFNG Recombinant Antibody (clone Haf25) | ELISA, Neut | Humanized IgG |
| HPAB-S0069-YC | Human Anti-IFNG Recombinant Antibody (clone HuXAF) | ELISA, Neut | Humanized IgG |
| VS1-YJ110 | Mouse Anti-IFNG Recombinant Antibody (clone G-23) | ELISA, IB, WB, FC, IP | Mouse IgG1 |
| VS1-YJ111 | Mouse Anti-IFNG Recombinant Antibody (clone G-23), FITC | WB, FC, ELISA | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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