IFNG encodes a soluble cytokine that is a member of the type II interferon class. IFNG is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in IFNG are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.

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