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IFNG

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In humans, the IFNγ protein is encoded by the IFNG gene. IFNγ (interferon gamma) is a dimerized soluble cytokine and is the only member of type II interferon. Interferon gamma or type II is a cytokine that is essential for resistance to viruses, innate and adaptive immunity in certain bacterial and protozoan infections. IFNγ is an important activator of macrophages and inducers expressed by macrophage and class II major histocompatibility complex (MHC) molecules. Abnormal IFNγ expression is associated with many autoinflammatory and autoimmune diseases. The importance of IFNγ in the immune system derives in part from its ability to directly inhibit viral replication, most importantly due to its immunostimulatory and immunomodulatory effects. As part of the innate immune response, IFNγ is mainly produced by natural killer (NK) and natural killer T (NKT) cells, and upon antigen-specific immunity, CD4Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells produce IFNγ. IFNγ is also produced by non-cytotoxic innate lymphocytes (ILCs), which were first discovered in early 2010 in the immune cell family. Interferon-gamma 1b is approved by the U.S. Food and Drug Administration for the treatment of chronic granulomatous diseases and osteopetrosis. Interferon gamma has not been approved for use in the treatment of any cancer immunotherapy. However, improved survival was observed when interferon gamma was administered to bladder and melanoma cancer patients. Fontolizumab (the planned brand name HuZAF) is a humanized monoclonal antibody, an immunosuppressive drug used to treat autoimmune diseases such as Crohn's disease. The Phase II clinical trial to investigate the use of rheumatoid arthritis was terminated because the first phase did not reach the end point.

Derivation:
Humanized
Species Reactivity:
Human
Type:
IgG
Application:
Neut, ELISA
Derivation:
Rat
Species Reactivity:
Human
Type:
IgG
Application:
Neut
Species Reactivity:
Canine
Application:
WB, ELISA
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
Neut, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
Neut, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Species Reactivity:
Human
Type:
IgG1
Application:
Neut
Species Reactivity:
Human
Type:
IgG2b
Application:
FC, CyTOF, Neut
Species Reactivity:
Human
Application:
FC, Neut
Species Reactivity:
Human
Type:
IgG2
Application:
FC, IHC-Fr, Neut
Species Reactivity:
Human
Type:
IgG1, κ
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
IgG1, κ
Application:
Neut, sELISA
Species Reactivity:
Mouse, Rat
Type:
IgG1
Application:
ELISA, Neut
Species Reactivity:
Human
Type:
IgG1
Application:
ELISA, WB, Neut
Species Reactivity:
Human
Type:
IgG1
Application:
Neut, FC, ELISA
Species Reactivity:
Human
Type:
IgG1, κ
Application:
ELISA, FC, ICC, IP, Neut
Species Reactivity:
Human
Type:
IgG1
Application:
Inhib, IHC, IP
Species Reactivity:
Human, Primates
Type:
IgG1
Application:
FC, ICC, Neut
Species Reactivity:
Human
Type:
IgG
Application:
Neut, ELISA
Species Reactivity:
Human
Type:
IgG2b
Application:
CyTOF, ICC, ICFC, Neut
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