Afuco™ Anti-Human LTBR ADCC Recombinant Antibody (BG9924), ADCC Enhanced (CAT#: AFC-484CL)
Anti-LTBR ADCC Enhanced Antibody (BG9924) is an ADCC enhanced antibody produced by our Afuco™ platform. The Phase II trial of baminercept (BG9924, LTβR-Ig) in rheumatoid arthritis (RA) patients who have had an inadequate response to conventional therapy with a disease-modifying antirheumatic drug (DMARD) did not meet its primary endpoint. LTβR-Ig consists of the human LTβR extracellular domain fused to the human IgG1 Fc domain. It binds to LT α1/β2 and LIGHT ligands on activated lymphocytes and natural killer cells, blocking interactions with their receptors on peripheral antigen-presenting and stromal cells.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line
(Immunofluorescent staining of human cell line RT4 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61617/1766_D5_3_selected.jpg
(Immunofluorescent staining of human cell line RT4 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/61617/1766_D5_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/if_selected.jpg
Figure 3 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells of the red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/ihc_selected.jpg
(Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells of the red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/ihc_selected.jpg
Figure 4 Kidney
(Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_8_5.jpg
(Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_8_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_4_6.jpg
(Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_4_6.jpg
Figure 6 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_9_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (HHSteC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111321-LTBR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111321-LTBR
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- 95% by HPLC
- Storage
- Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Target
- Alternative Names
- LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III; tumor necrosis factor receptor superfamily member 3; lymphotoxin B receptor; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein
- Gene ID
- 4055
- UniProt ID
- P36941
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2179z | Mouse Anti-LTBR Recombinant Antibody (clone 28H4) | WB, FC | Mouse IgG1 |
| MOB-1634MZ | Recombinant Mouse Anti-Human LTBR Antibody (clone NN0572-4U35) | FC, WB | Mouse antibody |
| FN-022CQ | Recombinant Rat Anti-LTBR Antibody (3C8) | FC, FuncS, WB | Rat IgG1, κ |
| FN-024CQ | Recombinant Rat Anti-LTBR Antibody (4H8 WH2) | FC, FuncS | Rat IgG2a |
| VS7-0425-WR321 | Mouse Anti-LTBR Recombinant Antibody (clone 1D1C5C8) | WB, FC | Mouse IgG2a |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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