Afuco™ Anti-Human LTBR ADCC Recombinant Antibody (BG9924), ADCC Enhanced
CAT#: AFC-484CL
Anti-LTBR ADCC Enhanced Antibody (BG9924) is an ADCC enhanced antibody produced by our Afuco™ platform. The Phase II trial of baminercept (BG9924, LTβR-Ig) in rheumatoid arthritis (RA) patients who have had an inadequate response to conventional therapy with a disease-modifying antirheumatic drug (DMARD) did not meet its primary endpoint. LTβR-Ig consists of the human LTβR extracellular domain fused to the human IgG1 Fc domain. It binds to LT α1/β2 and LIGHT ligands on activated lymphocytes and natural killer cells, blocking interactions with their receptors on peripheral antigen-presenting and stromal cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line
Immunofluorescent staining of human cell line RT4 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61617/1766_D5_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/if_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells of the red pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/ihc_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_4_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26202/58102_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HHSteC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111321-LTBR
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Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- 95% by HPLC
- Storage
- Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Target
- Alternative Names
- LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III; tumor necrosis factor receptor superfamily member 3; lymphotoxin B receptor; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein
- Gene ID
- 4055
- UniProt ID
- P36941
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "LTBR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2179z | Mouse Anti-LTBR Recombinant Antibody (clone 28H4) | WB, FC | Mouse IgG1 |
| PABL-636 | Human Anti-LTBR Recombinant Antibody (clone BHA10) | WB, IF, FuncS | Human IgG |
| MOB-1634MZ | Recombinant Mouse Anti-Human LTBR Antibody (clone NN0572-4U35) | FC, WB | Mouse antibody |
| FN-022CQ | Recombinant Rat Anti-LTBR Antibody (3C8) | FC, FuncS, WB | Rat IgG1, κ |
| VS7-0425-WR321 | Mouse Anti-LTBR Recombinant Antibody (clone 1D1C5C8) | WB, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-504CL | Human Anti-LTBR Recombinant Antibody (TAB-504CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-631 | Human Anti-LTBR Recombinant Antibody (clone BHA10); Fab Fragment | WB, IF, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-631 | Human Anti-LTBR Recombinant Antibody (clone BHA10); scFv Fragment | WB, IF, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0331MZ | Chicken Anti-LTBR Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-098LC | Recombinant Rat Anti-Mouse Ltbr Agonist Antibody (5G11) | IP | Rat antibody |
| MOB-099LC | Recombinant Mouse Anti-Human LTBR Agonist Antibody (CBE11) | ELISA, FunS, WB, IP | Mouse antibody |
| MOB-100LC | Recombinant Humanized Anti-Human LTBR Agonist Antibody (huCBE11) | ELISA, FunS, WB, IP | Humanized antibody |
| VS-0724-XY34 | Rat Anti-Ltbr Agonistic Antibody (clone 4H8 WH2) | FC, Functional assays | Rat IgG2a |
| VS-0724-XY35 | Mouse Anti-LTBR Agonistic Antibody (VS-0724-XY35) | Agonistic assays | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC405 | Recombinant Anti-LTBR Vesicular Antibody, EV Displayed (VS-0425-YC405) | ELISA, FC, Cell-uptake |
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