Anti-CD22 (clone RFB4)-MC-MMAF ADC (CAT#: ADC-226CL)

This ADC product is composed of an anti-CD22 antibody (clone RFB4) conjugated via MC linker to MMAF(anti-CD22(RFB4)-MC-MMAF). It has demonstrated a response in treatment by a MOA (Mechanism of Action) as microtubule inhibitor.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Normal Tissue

RNA Expression


Specifications

  • Antibody Overview
  • Anti-CD22 Antibody RFB4
  • Clone
  • RFB4
  • Linker
  • Mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • MMAF (Monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
    CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
  • Alternative Names
  • CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2;

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Humanized Antibody

CAT Product Name Application Type
TAB-198 Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized (from mouse) IgG4, κ
TAB-899 Humanized Anti-CD22 Recombinant Antibody (clone Pinatuzumab) FC, IP, ELISA, Neut, FuncS, IF, ICC Humanized (from mouse) IgG1, κ
TAB-1725CL Human Anti-CD22 Recombinant Antibody (TAB-1725CL) Block, Cyt, ELISA, FuncS Humanized IgG
TAB-1729CL Human Anti-CD22 Recombinant Antibody (TAB-1729CL) IF, FC Humanized IgG
TAB-1725CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) Block, Cyt, ELISA, FuncS Humanized Fab

Immunotoxin

CAT Product Name Application Type
AGTO-L048E anti-CD22 immunotoxin RFB4 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L048D anti-CD22 immunotoxin RFB4 (scFv)-DT Cytotoxicity assay, Functional assay
AGTO-L048G anti-CD22 immunotoxin RFB4 (scFv)-Gel Cytotoxicity assay, Functional assay
AGTO-L048R anti-CD22 immunotoxin RFB4 (scFv)-RTA Cytotoxicity assay, Functional assay
AGTO-L048S anti-CD22 immunotoxin RFB4 (scFv)-Sap Cytotoxicity assay, Functional assay

Human Antibody

CAT Product Name Application Type
TAB-0196CL Anti-Human CD22 Recombinant Antibody (hLL2) Inhib, Cyt, FC, WB
TAB-1721CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.1) ELISA, FC, FuncS Human antibody
TAB-1722CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.2) ELISA, FC, FuncS Human antibody
TAB-1721CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.1) ELISA, FC, FuncS Human antibody
TAB-1722CL-F(E) Anti-Human CD22 Recombinant Antibody Fab Fragment (CD22.2) ELISA, FC, FuncS Human antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-1724CL Human Anti-CD22 Recombinant Antibody (TAB-1724CL) Inhib Chimeric (mouse/human) IgG1, κ
TAB-1724CL-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) Inhib Chimeric (mouse/human) Fab
TAB-001LC Human Anti-CD22 Recombinant Antibody (TAB-001LC) ELISA Chimeric antibody (mouse/human)
TAB-001LC-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) ELISA Mouse scFv
TAB-001LC-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) ELISA Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-1714CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1714CL-S(P)) ELISA, WB Mouse scFv
TAB-1723CL-S(P) Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1723CL-S(P)) Inhib Mouse scFv
TAB-1728CL-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment (RFB4) IF, FC
TAB-003LC-S(P) Mouse Anti-Human CD22 Recombinant Antibody scFv Fragment FC
TAB-004LC-S(P) Anti-Human CD22 Recombinant Antibody scFv Fragment FC

Fab Glycosylation

CAT Product Name Application Type
Gly-001LC Recombinant Anti-Human CD22 Antibody (Fab glycosylation) ELISA, FC Mouse antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-111LC Recombinant Anti-Human CD22 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

Blocking Antibody

CAT Product Name Application Type
NEUT-315CQ Rat Anti-CD22 Recombinant Antibody (clone 2D6) Block Rat IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0545 Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) IP, WB Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0195-LSX Human Anti-CD22 Recombinant Antibody (HPAB-0195-LSX) Apop, Cyt, FC, WB, Inhib, FuncS, IF, ELISA Human IgG
HPAB-0196-LSX Mouse Anti-CD22 Recombinant Antibody (HPAB-0196-LSX) ELISA, FC, IP, RIA Mouse IgG
HPAB-0197-LSX Human Anti-CD22 Recombinant Antibody (HPAB-0197-LSX) ELISA, FC, FuncS Human IgG
HPAB-0198-LSX Mouse Anti-CD22 Recombinant Antibody (HPAB-0198-LSX) ELISA, WB, IF, FC, SPR Mouse IgG
HPAB-0199-LSX Human Anti-CD22 Recombinant Antibody (HPAB-0199-LSX) ELISA, FC Human IgG1

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0194-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) ELISA Mouse Fab
HPAB-0195-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) ELISA Human Fab
HPAB-0196-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) ELISA Mouse Fab
HPAB-0197-LSX-F(E) Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) ELISA Human Fab
HPAB-0198-LSX-F(E) Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) ELISA, FC Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
FAMAB-0046-YC-S(P) Mouse Anti-CD22 Recombinant Antibody (clone m5/44); scFv Fragment ELISA, Cyt Mouse scFv
FAMAB-0047-YC-S(P) Human Anti-CD22 Recombinant Antibody (clone g5/44); scFv Fragment ELISA, Cyt Humanized scFv
FAMAB-0048-YC-S(P) Mouse Anti-CD22 Recombinant Antibody (clone ch5/44); scFv Fragment ELISA Mouse scFv
HPAB-0249-FY-S(P) Recombinant Human Anti-CD22 Antibody scFv Fragment F Human scFv
HPAB-0034-YJ-S(P) Mouse Anti-CD22 Recombinant Antibody (clone HB22-23); scFv Fragment Block Mouse scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-176 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-198 Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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