Anti-BRAF (clone CCTCC C2012122) Recombinant Antibody Coupled Liposome (VS-1024-FY37) (CAT#: VS-1024-FY37)

• Potential Clinical Applications
• Lung cancer, Glioma, Ovarian cancer, Pancreatic cancer

• Clone
• CCTCC C2012122

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant antibody derived from mouse sources, specifically designed to target the BRAF protein. BRAF is a crucial component of the MAPK/ERK signaling pathway, which plays a significant role in regulating cell division and growth. Dysregulation or mutations in the BRAF gene are commonly associated with various types of cancer, making it a key focus for therapeutic interventions and research.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• BRAF

• Introduction
• This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.

• Alternative Names
• B-Raf Proto-Oncogene, Serine/Threonine Kinase; V-Raf Murine Sarcoma Viral Oncogene Homolog B1; V-Raf Murine Sarcoma Viral Oncogene Homolog B; Proto-Oncogene B-Raf; BRAF1; RAFB1; B-Raf Proto-Oncogene Serine/Threonine-Protein Kinase (P94); Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; Serine/Threonine-Protein Kinase B-Raf

• Full Name
• B-Raf Proto-Oncogene, Serine/Threonine Kinase

• Gene ID
• 673

• UniProt ID
• P15056

• Sequence Similarities
• Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane, Nucleus

• Post Translation Modifications
• Phosphorylation at Ser-365 by SGK1 inhibits its activity.
  Methylation at Arg-671 decreases stability and kinase activity.
  Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF.

• Protein Refseq
• NP_004324.2

• Function
• Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126).
  May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179).

• TAB-1284CL
• Anti-Human BRAF Recombinant Antibody (CCTCC C2012122)

• TAB-1284CL-S(P)
• Anti-Human BRAF Recombinant Antibody scFv Fragment (CCTCC C2012122)

• TAB-1284CL-F(E)
• Anti-Human BRAF Recombinant Antibody Fab Fragment (CCTCC C2012122)

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