Zanolimumab Overview

Introduction of Zanolimumab

Zanolimumab (expected trade name HuMax-CD4) is a high affinity human monoclonal antibody and an immunosuppressive drug targeting the CD4-molecule. It was developed by Genmab A/S employing the patented HuMAb-Mouse® technology licensed from Medarex, Inc., for the treatment of rheumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma. Zanolimumab has previously been assessed in clinical trials in the therapy of inflammatory diseases like psoriasis and rheumatoid arthritis, where a favorable safety profile has been demonstrated. Although good tolerability was demonstrated, studies were discontinued in this field because of lack of significant efficacy. The significant T cell depletion in these trials promised benefit in malignant T cell disorders and therefore zanolimumab entered into clinical studies for these indications.

Mechanism of Action of Zanolimumab

Zanolimumab is a human monoclonal antibody specific for the CD4 antigen, which is expressed on a subset of T cells in rheumatoid arthritis, psoriasis, melanoma, cutaneous and peripheral T-cell lymphoma. Due to the interference with the interaction of the CD4 antigen and the major histocompatibility complex class II-molecule (MHC-II), this antibody dose-dependently decreases T cell activation. Zanolimumab inhibits CD4⁺ T cells by combining signaling inhibition with potent induction of Fc-mediated effector functions. T cell activation is inhibited by a fast dual mechanism in which the antibody abrogates signaling via the T cell receptor (TCR) and, in addition, down regulates T cell activation by transmission of direct inhibitory signals. In addition, zanolimumab induces killing of CD4+ T cells via antibody-dependent cellular cytotoxicity (ADCC) with no additional complement-dependent cytotoxicity (CDC).

Fig.1 Mechanism of action of zanolimumab

What We Provide

Therapeutic Antibody

Zanolimumab

We provide high-quality Zanolimumab for use in WB, FC, IP, ELISA, Neut, FuncS, IF and most other immunological methods. For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

For research use only. Not intended for any clinical use.