Mouse Anti-FN1 Recombinant Antibody (VS3-CJ306) (CAT#: VS3-CJ306)

This product is a mouse antibody that recognizes FN1.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Immunogen
  • Synthetic peptide
  • Host Species
  • Mouse
  • Specificity
  • Human FN1
  • Species Reactivity
  • Human
  • Applications
  • WB
  • Conjugate
  • Unconjugated

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Buffer
  • 50% Glycerol, PBS, pH7.4.
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot.

Target

  • Alternative Names
  • FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF
  • Cellular Localization
  • Extracellular matrix, Secreted
  • Post Translation Modifications
  • It is not known whether both or only one of Thr-2155 and Thr-2156 are/is glycosylated.
    Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
    Phosphorylated by FAM20C in the extracellular medium.
    Proteolytic processing produces the C-terminal NC1 peptide, anastellin.
    Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.
    Serotonylated on Gln residues by TGM2 in response to hypoxia.
  • Function
  • Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369).
    Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369).
    Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity).
    Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).
    Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617).
    Anastellin: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Recommended Products

Recommended Dilution Buffer

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "FN1"

Human Antibody

CAT Product Name Application Type
TAB-193 Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) IF, IP, Neut, FuncS, ELISA, FC, ICC [(scFv - heavy - kappa) - IGHE - CH4]2
TAB-001CQ Anti-Human FN1 Recombinant Antibody (MOR03255) ELISA, Block, IHC Human antibody
TAB-002CQ Anti-Human FN1 Recombinant Antibody (ME-4C) ELISA, IHC Human antibody
TAB-003CQ Anti-Human FN1 Recombinant Antibody (1C5) ELISA, WB Human antibody
TAB-004CQ Human Anti-FN1 Recombinant Antibody (TAB-004CQ) ELISA, IHC, WB Human IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-852CQ Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) ELISA, WB, IP, Block Mouse IgG1
NEUT-853CQ Mouse Anti-FN1 Recombinant Antibody (clone IST-9) WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1326 Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) IHC-Fr, IHC-P, IHC-P, IP, WB Rabbit IgG

Single-domain Antibody

CAT Product Name Application Type
NBD-0040-YJ-VHH Camelid Anti-FN1 Recombinant Single Domain Antibody (NBD-0040-YJ-VHH) ELISA, In vivo imaging Camelid VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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