Human Anti-HGF Recombinant Antibody (HPAB-J0117-YC)

Name: Human Anti-HGF Recombinant Antibody (HPAB-J0117-YC)
SKU: HPAB-J0117-YC
Rating: 5 (1 reviews)

CAT#: HPAB-J0117-YC

Provided is a humanized neutralizing mAb to human Hepatocyte Growth Factor (HGF). The mAb inhibits at least one, and preferably several or all biological activities of HGF including binding to its receptor cMet, induction of scattering of cells such as Madin-Darby canine kidney cells, induction of proliferation of Mv 1 Lu mink lunk epithelial cells and/or hepatocytes and/or HUVEC, and stimulation of angiogenesis. A preferred humanized anti-HGF mAb inhibits, most preferably completely inhibits, growth of a human tumor xenograft in a mouse.

Gene Expression

Normal Tissue Figure 1 IHC staining of human rectum

Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/ihc_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_B_8_5.jpg

Normal Tissue Figure 3 Colon

Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_5_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced.

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000019991-HGF

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Specifications

Host Species
Human

Derivation
Chimeric (mouse/human)

Type
Chimeric (mouse/human) IgG

Specificity
Human HGF

Species Reactivity
Human

Applications
ELISA, Neut, FuncS

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Hepatocyte Growth Factor; Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor); Fibroblast-Derived Tumor Cytotoxic Factor; Lung Fibroblast-Derived Mitogen; Hepatopoietin-A; Scatter Factor; HPTA; SF

Gene ID
3082

UniProt ID
P14210

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-J0117-YC.pdf

MSDS

MSDS - HPAB-J0117-YC.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
TAB-080	Human Anti-HGF Recombinant Antibody (TAB-080)	WB, ELISA, FC, IP, FuncS, IF, Neut	Human IgG2, κ
TAB-076CT	Anti-Human HGF/SF Recombinant Antibody (2C3)	ELISA, WB	Human antibody
TAB-076CT-S(P)	Anti-Human HGF/SF Recombinant Antibody scFv Fragment (2C3)	ELISA, WB	Human antibody
TAB-076CT-F(E)	Anti-Human HGF/SF Recombinant Antibody Fab Fragment (2C3)	ELISA, WB	Human antibody

CAT	Product Name	Application	Type
TAB-749	Anti-HGF Recombinant Antibody (TAB-749)	ELISA, FC, IP, FuncS, IF, Neut, WB	IgG1 - kappa
TAB-075CT	Human Anti-HGF Recombinant Antibody (TAB-075CT)	ELISA, Neut	Humanized antibody
TAB-075CT-S(P)	Human Anti-HGF Recombinant Antibody; scFv Fragment (TAB-075CT-S(P))	ELISA, Neut	Humanized scFv
TAB-075CT-F(E)	Human Anti-HGF Recombinant Antibody; Fab Fragment (TAB-075CT-F(E))	ELISA, Neut	Humanized Fab

CAT	Product Name	Application	Type
PFBL-132	Rabbit Anti-HGF Recombinant Antibody; Fab Fragment (PFBL-132)	WB, ELISA, FuncS	Rabbit Fab
HPAB-0713-FY-S(P)	Mouse Anti-HGF Recombinant Antibody (clone AB012); Fab Fragment	ELISA	Mouse Fab
HPAB-0821-FY-S(P)	Mouse Anti-HGF Recombinant Antibody (clone S265109B10); Fab Fragment	Neut, ELISA	Mouse Fab
HPAB-0822-FY-S(P)	Mouse Anti-HGF Recombinant Antibody (clone S260115C11); Fab Fragment	Neut, ELISA	Mouse Fab
HPAB-0823-FY-S(P)	Human Anti-HGF Recombinant Antibody (clone S260105B02); Fab Fragment	Neut, ELISA	Chimeric (mouse/human) Fab

CAT	Product Name	Application	Type
TAB-078CT	Llama Anti-HGF Recombinant Single Domain Antibody (TAB-078CT)	Block	Llama VHH
HPAB-0993WJ	Recombinant Camelid Anti-HGF Single Domain Antibody (HPAB-0993WJ)	ELISA	Camelid VHH
HPAB-0994WJ	Recombinant Human Anti-HGF Antibody (HPAB-0994WJ)	ELISA	Humanized sdAb

CAT	Product Name	Application	Type
NEUT-900CQ	Mouse Anti-HGF Recombinant Antibody (clone 24612.111)	ELISA, WB, Neut	Mouse IgG1
NEUT-901CQ	Mouse Anti-HGF Recombinant Antibody (clone 5D20)	WB, Neut	Mouse IgG1
NEUT-902CQ	Mouse Anti-HGF Recombinant Antibody (clone CBL070)	Neut, WB	Mouse IgG1
NEUT-903CQ	Mouse Anti-HGF Recombinant Antibody (clone CBL435)	WB, Neut	Mouse IgG1
NEUT-904CQ	Mouse Anti-HGF Recombinant Antibody (clone CBL1017)	Neut	Mouse IgG1

CAT	Product Name	Application	Type
MOR-1591	Rabbit Anti-HGF Recombinant Antibody (clone DS1591AB)	ELISA	Rabbit IgG
MOR-4217	Rabbit Anti-HGF Recombinant Antibody (clone SI296DS)	ELISA	Rabbit IgG
MOR-4585	Rabbit Anti-HGF Recombinant Antibody (clone TH98DS)	WB, IF, ICC, FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0651-CN	Mouse Anti-HGF Recombinant Antibody (HPAB-0651-CN)	IHC, WB, FC	Mouse IgG1, κ
HPAB-0652-CN	Mouse Anti-HGF Recombinant Antibody (HPAB-0652-CN)	ELISA, Neut	Mouse IgG1, κ
HPAB-0653-CN	Mouse Anti-HGF Recombinant Antibody (HPAB-0653-CN)	ELISA, Neut	Mouse IgG1, κ
HPAB-0654-CN	Mouse Anti-HGF Recombinant Antibody (HPAB-0654-CN)	ELISA, Neut	Mouse IgG1, κ
HPAB-0655-CN	Mouse Anti-HGF Recombinant Antibody (HPAB-0655-CN)	ELISA, Neut	Mouse IgG1, κ

CAT	Product Name	Application	Type
AFC-TAB-130	Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-130)	Neut, ELISA, IF, IP, FuncS, FC	ADCC enhanced antibody
AFC-TAB-749	Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-749)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody
AFC-TAB-080	Afuco™ Anti-HGF Recombinant Antibody (AFC-TAB-080), ADCC Enhanced	ELISA, FC, IP, FuncS, IF	Human IgG1, κ

CAT	Product Name	Application	Type
HPAB-0713-FY-F(E)	Mouse Anti-HGF Recombinant Antibody (clone AB012); scFv Fragment	ELISA	Mouse scFv
HPAB-0821-FY-F(E)	Mouse Anti-HGF Recombinant Antibody (clone S265109B10); scFv Fragment	Neut, ELISA	Mouse scFv
HPAB-0822-FY-F(E)	Mouse Anti-HGF Recombinant Antibody (clone S260115C11); scFv Fragment	Neut, ELISA	Mouse scFv
HPAB-0823-FY-F(E)	Mouse Anti-HGF Recombinant Antibody (clone S260105B02); scFv Fragment	Neut, ELISA	Mouse scFv
HPAB-0990WJ-S(P)	Human Anti-HGF Recombinant Antibody (clone 2.12.1); scFv Fragment	ELISA	Human scFv

CAT	Product Name	Application
VS-0325-XY1015	Anti-HGF Immunohistochemistry Kit	IHC
VS-0525-XY3130	Anti-Mouse HGF Immunohistochemistry Kit	IHC
VS-0525-XY3129	Anti-Human HGF Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0425-FY25	Human Anti-HGF (clone BPC2015) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc

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