Human Anti-HGF Recombinant Antibody (HPAB-J0117-YC)
CAT#: HPAB-J0117-YC
Provided is a humanized neutralizing mAb to human Hepatocyte Growth Factor (HGF). The mAb inhibits at least one, and preferably several or all biological activities of HGF including binding to its receptor cMet, induction of scattering of cells such as Madin-Darby canine kidney cells, induction of proliferation of Mv 1 Lu mink lunk epithelial cells and/or hepatocytes and/or HUVEC, and stimulation of angiogenesis. A preferred humanized anti-HGF mAb inhibits, most preferably completely inhibits, growth of a human tumor xenograft in a mouse.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40360/92262_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000019991-HGF
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Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric (mouse/human) IgG
- Specificity
- Human HGF
- Species Reactivity
- Human
- Applications
- ELISA, Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-080 | Human Anti-HGF Recombinant Antibody (TAB-080) | WB, ELISA, FC, IP, FuncS, IF, Neut | Human IgG2, κ |
| TAB-076CT | Anti-Human HGF/SF Recombinant Antibody (2C3) | ELISA, WB | Human antibody |
| TAB-076CT-S(P) | Anti-Human HGF/SF Recombinant Antibody scFv Fragment (2C3) | ELISA, WB | Human antibody |
| TAB-076CT-F(E) | Anti-Human HGF/SF Recombinant Antibody Fab Fragment (2C3) | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-749 | Anti-HGF Recombinant Antibody (TAB-749) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
| TAB-075CT | Human Anti-HGF Recombinant Antibody (TAB-075CT) | ELISA, Neut | Humanized antibody |
| TAB-075CT-S(P) | Human Anti-HGF Recombinant Antibody; scFv Fragment (TAB-075CT-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-075CT-F(E) | Human Anti-HGF Recombinant Antibody; Fab Fragment (TAB-075CT-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-132 | Rabbit Anti-HGF Recombinant Antibody; Fab Fragment (PFBL-132) | WB, ELISA, FuncS | Rabbit Fab |
| HPAB-0713-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone AB012); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0821-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone S265109B10); Fab Fragment | Neut, ELISA | Mouse Fab |
| HPAB-0822-FY-S(P) | Mouse Anti-HGF Recombinant Antibody (clone S260115C11); Fab Fragment | Neut, ELISA | Mouse Fab |
| HPAB-0823-FY-S(P) | Human Anti-HGF Recombinant Antibody (clone S260105B02); Fab Fragment | Neut, ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-078CT | Llama Anti-HGF Recombinant Single Domain Antibody (TAB-078CT) | Block | Llama VHH |
| HPAB-0993WJ | Recombinant Camelid Anti-HGF Single Domain Antibody (HPAB-0993WJ) | ELISA | Camelid VHH |
| HPAB-0994WJ | Recombinant Human Anti-HGF Antibody (HPAB-0994WJ) | ELISA | Humanized sdAb |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-900CQ | Mouse Anti-HGF Recombinant Antibody (clone 24612.111) | ELISA, WB, Neut | Mouse IgG1 |
| NEUT-901CQ | Mouse Anti-HGF Recombinant Antibody (clone 5D20) | WB, Neut | Mouse IgG1 |
| NEUT-902CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL070) | Neut, WB | Mouse IgG1 |
| NEUT-903CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL435) | WB, Neut | Mouse IgG1 |
| NEUT-904CQ | Mouse Anti-HGF Recombinant Antibody (clone CBL1017) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1591 | Rabbit Anti-HGF Recombinant Antibody (clone DS1591AB) | ELISA | Rabbit IgG |
| MOR-4217 | Rabbit Anti-HGF Recombinant Antibody (clone SI296DS) | ELISA | Rabbit IgG |
| MOR-4585 | Rabbit Anti-HGF Recombinant Antibody (clone TH98DS) | WB, IF, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0651-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0651-CN) | IHC, WB, FC | Mouse IgG1, κ |
| HPAB-0652-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0652-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0653-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0653-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0654-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0654-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0655-CN | Mouse Anti-HGF Recombinant Antibody (HPAB-0655-CN) | ELISA, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-130 | Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-130) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-749 | Afuco™ Anti-HGF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-749) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| AFC-TAB-080 | Afuco™ Anti-HGF Recombinant Antibody (AFC-TAB-080), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0713-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone AB012); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0821-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone S265109B10); scFv Fragment | Neut, ELISA | Mouse scFv |
| HPAB-0822-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone S260115C11); scFv Fragment | Neut, ELISA | Mouse scFv |
| HPAB-0823-FY-F(E) | Mouse Anti-HGF Recombinant Antibody (clone S260105B02); scFv Fragment | Neut, ELISA | Mouse scFv |
| HPAB-0990WJ-S(P) | Human Anti-HGF Recombinant Antibody (clone 2.12.1); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1015 | Anti-HGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY3130 | Anti-Mouse HGF Immunohistochemistry Kit | IHC | |
| VS-0525-XY3129 | Anti-Human HGF Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY25 | Human Anti-HGF (clone BPC2015) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
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