Human Anti-HIV gp120 Recombinant Antibody (clone m14)
CAT#: FAMAB-0242JF
Recombinant monoclonal antibody specially binds to the CD40 binding site of HIV gp120 and gp140. This human anti-gp120 antibody (m14) is a novel CD4bs cross-reactive HIV-1 neutralizing antibody that exhibits a novel inhibitory profile, and may have implications for our understanding of the mechanisms of immune evasion and for the development of inhibitors and vaccines.
Published Data
IHC
Figure 1 Representative images of gp120 exposed primary mixed human CNS aggregate cultures at 4 weeks in vitro after Asc-p supplementation.
Error bars: +/- 1 standard error.
Walsh, K. A., Megyesi, J. F., Wilson, J. X., Crukley, J., Laubach, V. E., & Hammond, R. R. (2004). Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity. Journal of neuroinflammation, 1(1), 1-14.
IF
Figure 2 Immunofluorescence imaging by confocal microscopy was performed for detection of iNOS antigens.
Each panel of images shows individual fluorophores and merged fluorophores with colocalization represented in yellow.
Walsh, K. A., Megyesi, J. F., Wilson, J. X., Crukley, J., Laubach, V. E., & Hammond, R. R. (2004). Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity. Journal of neuroinflammation, 1(1), 1-14.
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Specifications
- Host Species
- Human
- Derivation
- Human phage display Fab library
- Type
- Human IgG1
- Specificity
- HIV gp120, HIV gp140,
- Species Reactivity
- HIV
- Clone
- m14
- Applications
- WB, ELISA, IHC, FC, IF
- Related Disease
- HIV-1 infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV gp120 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Flow Cytometry, Immunofluorescence.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone m14"
- CAT
- Product Name
See other products for "HIV GP120"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B053(A) | Recombinant Anti-HIV gp120 Intrabody [(D-Arg)9] | ELISA, ICC, FuncS | scFv-(D-Arg)9 |
| IAB-B053(G) | Recombinant Anti-HIV gp120 Intrabody [+36 GFP] | PCA, Neut, FuncS | scFv-(+36GFP) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-412-S(P) | Recombinant Human Anti-HIV gp120 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| FAMAB-0232JF-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone 257-D); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0242JF-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone m14); scFv Fragment | ELISA, FuncS | Human scFv |
| FAMAB-0177WJ-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone SF12); scFv Fragment | ELISA, WB, Neut | Human scFv |
| PABJ-0031-S(P) | Bovine Anti-HIV gp120 Recombinant Antibody; scFv Fragment (PABJ-0031-S(P)) | ELISA, Neut | Bovine scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-023LC | Anti-HIV gp120 Recombinant Antibody (HY498) | ELISA | Human antibody |
| MRO-182LC | Anti-HIV gp120 Recombinant Antibody (58.2) | ELISA | Human antibody |
| MRO-023LC-S(P) | Anti-HIV gp120 Recombinant Antibody scFv Fragment (HY498) | ELISA | Human antibody |
| MRO-182LC-S(P) | Anti-HIV gp120 Recombinant Antibody scFv Fragment (58.2) | ELISA | Human antibody |
| MRO-183LC-S(P) | Anti-HIV gp120 Recombinant Antibody scFv Fragment (59.1) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1452-FY | Human Anti-HIV gp120 Recombinant Antibody (HPAB-1452-FY) | Neut, ELISA, FC, Block | Human IgG |
| HPAB-1454-FY | Human Anti-HIV gp120 Recombinant Antibody (HPAB-1454-FY) | Neut, ELISA, FC, Block | Human IgG |
| FAMAB-0080WJ | Human Anti-HIV gp120 Recombinant Antibody (clone NO.13) | ELISA, WB | Human IgG1, λ |
| FAMAB-0232JF | Human Anti-HIV gp120 Recombinant Antibody (clone 257-D) | ELISA, FuncS | Human IgG1 |
| FAMAB-1359CQ | Mouse Anti-HIV gp120 Recombinant Antibody (clone u5.5) | Neut, WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0547YY | Human Anti-HIV gp120 Recombinant Antibody (HPAB-0547YY) | ELISA, FuncS | Human IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0556YY-F(E) | Human Anti-HIV gp120 Recombinant Antibody (clone DRVIA7H+gDRVI01-L57); Fab Fragment | ELISA, Neut | Human Fab |
| HPAB-0555YY-F(E) | Human Anti-HIV gp120 Recombinant Antibody (clone DRVIA7H+gDRVI01-L40); Fab Fragment | ELISA, Neut | Human Fab |
| HPAB-0543YY-F(E) | Human Anti-HIV gp120 Recombinant Antibody; Fab Fragment (HPAB-0543YY-F(E)) | ELISA, FuncS | Human Fab |
| FAMAB-0232JF-F(E) | Human Anti-HIV gp120 Recombinant Antibody (clone 257-D); Fab Fragment | ELISA, FuncS | Human Fab |
| FAMAB-0242JF-F(E) | Human Anti-HIV gp120 Recombinant Antibody (clone m14); Fab Fragment | ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY70 | Human Anti-HIV gp120 (clone 2G12) scFv-Fc Chimera | Neut | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC97 | Recombinant Anti-HIV gp120 Biparatopic Antibody, Tandem scFv (Clone 257-D x Clone m14) | ELISA | Tandem scFv |
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