Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5) (CAT#: FAMAB-0006WJ)
This product is a chimeric (mouse/human) antibody targeting human myelin oligodendrocyte glycoprotein.
Specific Inquiry
IF
Figure 1 Myelin and astroglial reactivity of MS-mAb.
Confocal micrographs of immunofluorescence stainings on human MS brain tissue, CIS1-92 (red), anti-MOG 8-18c5 antibody (green).
von Büdingen, H. C., Harrer, M. D., Kuenzle, S., Meier, M., & Goebels, N. (2008). Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin‐specific antibodies. European journal of immunology, 38(7), 2014-2023.
FC
Figure 2 mAb derived from cePC do not react with MOG or MBP.
Histograms of flow cytometry experiments with a eukaryotic cell line (Jurkat) transfected to express human MOG on its surface. Note the clear reactivity (shift to the right) of humanized anti-MOG h8-18c5 antibody (open histogram). In comparison, no reactivity of MS-mAb or the isotype control (dark grey histogram) with MOG-expressing Jurkat cells could be detected.
von Büdingen, H. C., Harrer, M. D., Kuenzle, S., Meier, M., & Goebels, N. (2008). Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin‐specific antibodies. European journal of immunology, 38(7), 2014-2023.
ELISA
Figure 3 mAb derived from cePC do not react with MOG or MBP.
ELISA experiments demonstrating the lack of reactivity with recombinant MOG and purified human MBP.
von Büdingen, H. C., Harrer, M. D., Kuenzle, S., Meier, M., & Goebels, N. (2008). Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin‐specific antibodies. European journal of immunology, 38(7), 2014-2023.
FC
Figure 4 Ms and control-derived rigg binding to MOg detected with a cell-based assay.
Representative binding of MS (MS-B1) or germinoma control-derived (GCT-A3) rIgG to Jurkat cells transfected with MOG-GFP (left column) or GFP alone (right column). A humanized monoclonal antibody, h8-18c5, specific for human MOG served as a positive control for the Jurkat–MOG–GFP binding.
Willis, S. N., Stathopoulos, P., Chastre, A., Compton, S. D., Hafler, D. A., & O’Connor, K. C. (2015). Investigating the antigen specificity of multiple sclerosis central nervous system-derived immunoglobulins. Frontiers in immunology, 6, 600.
Specifications
- Host Species
- Human
- Type
- Chimeric (mouse/human) IgG
- Specificity
- Human MOG
- Species Reactivity
- Human
- Clone
- h8-18C5
- Applications
- IF, FC, ELISA
- Related Disease
- Multiple sclerosis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The MOG antibody has been reported in applications of Immunofluorescence, Flow Cytometry, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- MOG; myelin oligodendrocyte glycoprotein; BTN6; BTNL11; MOGIG2; NRCLP7; myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5
- Gene ID
- 4340
- UniProt ID
- Q16653
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone h8-18C5"
- FAMAB-0006WJ-F(E)
- Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5); Fab Fragment
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-670-F(E) | Recombinant Anti-human MOG Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| PFBZ-152 | Mouse Anti-MOG Recombinant Antibody (clone 8-18C5); Fab Fragment | WB | Mouse Fab |
| HPAB-1774-FY-S(P) | Human Anti-MOG Recombinant Antibody (clone AB138); Fab Fragment | Neut | Chimeric (marmoset/human) Fab |
| FAMAB-0006WJ-F(E) | Chimeric (mouse/human) Anti-MOG Recombinant Antibody (clone h8-18C5); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
| FAMAB-0228JF-F(E) | Monkey Anti-MOG Recombinant Antibody (clone M12E); Fab Fragment | ELISA, FuncS | Monkey Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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