Anti-MS4A1 (clone RW005) Recombinant Antibody Coupled Liposome (VS-1024-FY266)
CAT#: VS-1024-FY266
By using antibodies that specifically recognize the surface marker CD20 on leukemia cells, these immunoliposomes can potentially be used to selectively target and treat leukemia. Animal model experiments demonstrate that these liposomes have effective inhibitory effects on tumor progression, highlighting their potential as non-viral carriers for the targeted delivery of specific oligonucleotides.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/1778_G3_5_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/201_H5_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/202_H5_1_red_green.jpg
Normal Tissue
Figure 4 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_3.jpg
Normal Tissue
Figure 5 Bone marrow
Hematopoietic cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_B_4_4.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14341/39081_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (Daudi, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156738-MS4A1
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More Infomation
Specifications
- Potential Clinical Applications
- These immunoliposomes can potentially be used to selectively target leukemia cells for treatment.
Product Composition
- Clone
- RW005
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a chimeric monoclonal antibody targeting the CD20 protein, predominantly present on the surface of B cells within the immune system (distinct from pancreatic β- or beta cells). By inducing the destruction of B cells, this antibody is utilized in the treatment of conditions marked by an overabundance, hyperactivity, or dysfunction of B cells. Such conditions include various lymphomas, leukemias, transplant rejection episodes, and autoimmune diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MS4A1
- Introduction
- This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
- Alternative Names
- Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1
- Full Name
- Membrane Spanning 4-Domains A1
- Gene ID
- 931
- UniProt ID
- P11836
- Sequence Similarities
- Belongs to the MS4A family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.
- Protein Refseq
- NP_068769.2; NP_690605.1
- Function
- B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes.
Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone RW005"
- CAT
- Product Name
See other products for "MS4A1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-207 | Anti-Human CD20 Recombinant Antibody | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-1670CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1670CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
| TAB-1671CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1671CL-F(E)) | CDC | Chimeric (mouse/human) Fab |
| TAB-1675CL-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (TAB-1675CL-F(E)) | ELISA, WB | Chimeric (mouse/human) Fab |
| PABX-026 | Recombinant Human Anti-CD20 Antibody (C2H7) | FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-017 | Anti-Human CD20 Recombinant Antibody (TAB-017) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG2a - lambda |
| TAB-711 | Anti-MS4A1 Recombinant Antibody (Technetium (99MTC) Nofetumomab Merpentan) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Fab - G2b - kappa |
| TAB-001 | Anti-Human CD20 Recombinant Antibody (Ibritumomab) | ELISA, IP, FC, FuncS, IF, Neut | IgG1 - kappa |
| TAB-H27 | Anti-Human MS4A1 Recombinant Antibody (Epitumomab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG2a |
| TAB-H39 | Anti-Human MS4A1 Recombinant Antibody (Ibritumomab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Mouse IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1635CL | Anti-Human MS4A1 Recombinant Antibody (BVX20) | Inhib | Humanized antibody |
| TAB-1636CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1636CL) | ADCC, CDC | Humanized IgG |
| TAB-1637CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1637CL) | ADCC, CDC | Humanized IgG |
| TAB-1638CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1638CL) | ADCC, CDC | Humanized IgG |
| TAB-1639CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1639CL) | ADCC, CDC, Apop | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1645CL | Anti-Human MS4A1 Recombinant Antibody (2.1.2) | Cyt, FuncS | Fully human antibody |
| TAB-1646CL | Anti-Human MS4A1 Recombinant Antibody (1.1.2) | Cyt, FuncS | Fully human antibody |
| TAB-1647CL | Anti-Human MS4A1 Recombinant Antibody (1.5.3) | Cyt, FuncS | Fully human antibody |
| TAB-1648CL | Anti-MS4A1 Recombinant Antibody (MEDI-552) | Inhib | |
| TAB-1654CL | Human Anti-MS4A1 Recombinant Antibody (TAB-1654CL) | FC, Apop | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-059LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-063LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
| Gly-097LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-115LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| Gly-138LC | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-063LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (mouse/human) |
| Gly-134LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-135LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-136LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| Gly-137LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-142LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-155LC-1 | Recombinant Anti-Human MS4A1 Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-171LC | Recombinant Anti-Human MS4A1 Antibody (Non-glycosylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC066 | PE-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC067 | APC-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC068 | BV421-A*02:01/Human CD20 (SLFLGILSV) MHC Tetramer | FCM | |
| MHC-LC4347 | PE-B*07:02/Human MS4A1 (RPKSNIVLL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1751CQ | Mouse Anti-MS4A1 Recombinant Antibody (clone CBLS-211) | Neut, FuncS | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2295 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone DS2295AB) | IHC-Fr, IHC-P | Rabbit IgG |
| MOR-4024 | Hi-Affi™ Rabbit Anti-MS4A1 Recombinant Antibody (clone SI88DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0144-CN-S(P) | Human Anti-MS4A1 Recombinant Antibody (clone C2B8); scFv Fragment | WB, ELISA | Mouse scFv |
| HPAB-1896LY-S(P) | Mouse Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-1896LY-S(P)) | ELISA, Inhib | Mouse scfv |
| HPAB-1897LY-S(P) | Human Anti-MS4A1 Recombinant Antibody scFv Fragment (HPAB-1897LY-S(P)) | ELISA, Inhib | Chimeric scfv |
| HPAB-1898LY-S(P) | Human Anti-MS4A1 Recombinant Antibody; scFv Fragment (HPAB-1898LY-S(P)) | ELISA, Inhib | Humanized scfv |
| HPAB-1321-FY-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-1321-FY-F(E)) | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0683-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone Rmut8); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-0684-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody (clone Rmut5); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-0742-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0742-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0743-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0743-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0744-CN-F(E) | Human Anti-MS4A1 Recombinant Antibody; Fab Fragment (HPAB-0744-CN-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1693LY | Mouse Anti-MS4A1 Recombinant Antibody (HPAB-1693LY) | Neut, FC, IHC-Fr, IHC-P, IP | Mouse IgG |
| HPAB-1694LY | Human Anti-MS4A1 Recombinant Antibody (HPAB-1694LY) | Inhib | Humanized IgG |
| HPAB-0138-WJ | Human Anti-MS4A1 Recombinant Antibody (clone L4H7) | ELISA | Humanized IgG |
| HPAB-0139-WJ | Human Anti-MS4A1 Recombinant Antibody (clone L4H5) | ELISA | Humanized IgG |
| HPAB-1321-FY | Human Anti-MS4A1 Recombinant Antibody (HPAB-1321-FY) | FC, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0706-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0706-YC) | ELISA | Camelid VHH |
| HPAB-M0707-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0707-YC) | ELISA | Camelid VHH |
| HPAB-M0708-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0708-YC) | ELISA | Camelid VHH |
| HPAB-M0709-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0709-YC) | ELISA | Camelid VHH |
| HPAB-M0710-YC | Camelid Anti-MS4A1 Recombinant Antibody (HPAB-M0710-YC) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-772 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-772) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-016 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-016) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-028 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-028) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-207 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-207) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| AFC-TAB-771 | Afuco™ Anti-MS4A1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-771) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY188 | AbPlus™ Anti-MS4A1 Magnetic Beads (VS-0424-XY188) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC138 | Human Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC138), CDC Enhanced | FC, CDC, IP | Antibody hexamer |
| VS-0924-YC139 | Mouse Anti-MS4A1 Recombinant Antibody Hexamer (VS-0924-YC139), CDC Enhanced | FC, Activ, Agonist, IF, WB, Cyt, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY85 | Mouse Anti-NHP MS4A1 Recombinant Antibody (VS-1024-XY85) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY30 | Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera | FuncS | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY168 | CytoStream™ Rat Anti-MS4A1 Recombinant Antibody (clone GOT214A) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC513 | Recombinant Anti-MS4A1 Vesicular Antibody, EV Displayed (VS-0425-YC513) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4510 | Anti-MS4A1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4511 | Anti-Mouse MS4A1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC129 | Recombinant Anti-MS4A1 (Bin I x Bin II) Biparatopic Antibody, Tandem scFv | ELISA, FC | Tandem scFv |
| VS-0525-YC222 | Recombinant Anti-MS4A1 Biparatopic Antibody, Tandem scFv | ELISA, IF, WB | Tandem scFv |
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