Anti-MS4A1 (clone RW005) Recombinant Antibody Coupled Liposome (VS-1024-FY266) (CAT#: VS-1024-FY266)

• Potential Clinical Applications
• These immunoliposomes can potentially be used to selectively target leukemia cells for treatment.

• Clone
• RW005

• Antibody Type
• IgG1, kappa

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a chimeric monoclonal antibody targeting the CD20 protein, predominantly present on the surface of B cells within the immune system (distinct from pancreatic β- or beta cells). By inducing the destruction of B cells, this antibody is utilized in the treatment of conditions marked by an overabundance, hyperactivity, or dysfunction of B cells. Such conditions include various lymphomas, leukemias, transplant rejection episodes, and autoimmune diseases.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• MS4A1

• Introduction
• This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

• Alternative Names
• Membrane Spanning 4-Domains A1; Membrane-Spanning 4-Domains, Subfamily A, Member 1; Leukocyte Surface Antigen Leu-16; CD20 Antigen; CD20; Bp35; Membrane-Spanning 4-Domains Subfamily A Member 1; B-Lymphocyte Cell-Surface Antigen B1; B-Lymphocyte Surface Antigen B1

• Full Name
• Membrane Spanning 4-Domains A1

• Gene ID
• 931

• UniProt ID
• P11836

• Sequence Similarities
• Belongs to the MS4A family.

• Cellular Localization
• Cell membrane, Membrane

• Post Translation Modifications
• Phosphorylated on serines and threonines in resting B-cells. Protein kinase C/PKC can use CD20 as substrate.

• Protein Refseq
• NP_068769.2; NP_690605.1

• Function
• B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes.
  Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.

• HPAB-AP384-YC
• Human Anti-MS4A1 Recombinant Antibody (clone RW005)

• HPAB-AP384-YC-S(P)
• Human Anti-MS4A1 Recombinant Antibody (clone RW005); scFv Fragment

• HPAB-AP384-YC-F(E)
• Human Anti-MS4A1 Recombinant Antibody (clone RW005); Fab Fragment

• VS-0125-FY30
• Human Anti-MS4A1 (clone RW005) scFv-Fc Chimera

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