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Cd274

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This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, IF, FuncS
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Application:
ELISA, FC
Derivation:
Chimeric (mouse/human)
Type:
Chimeric antibody (mouse/human)
Application:
ELISA, FC
Derivation:
Humanized
Type:
Humanized antibody
Application:
ELISA, FC
Derivation:
Yeast display library
Type:
Human antibody
Application:
ELISA
Type:
Human antibody
Application:
ELISA, FC
Derivation:
Phage-display library
Type:
Human antibody
Application:
FC, ELISA
Type:
Human antibody
Application:
FC
Type:
Human antibody
Application:
FC
Type:
Human antibody
Application:
FC
Type:
Human antibody
Application:
FC
Type:
Human antibody
Application:
FC
Application:
WB, IHC
Application:
FC
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