CD274

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For Research Use Only. Not For Clinical Use.


Background

The CD274 gene codes for PD-L1 (Programmed Death-Ligand 1), a crucial immune checkpoint protein that helps regulate immune responses, especially by suppressing T-cells to prevent autoimmunity but also allowing tumors to evade detection. It's a key biomarker for predicting response to immunotherapy (like PD-1 inhibitors) in cancers, as high CD274/PD-L1 expression often indicates a better outcome with these treatments, though its amplification can also be a feature in some cancers like lymphomas.
Cd274
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