CD44 & CD28

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The CD44 antigen is a glycoprotein found on the surface of cells that plays a crucial role in cell-cell interactions, adhesion, and migration. In humans, the gene that encodes CD44 is located on chromosome 11. This antigen is also known by several other names, including HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1.