CDK4

Creative Biolabs specializes in premium anti-CDK4 antibodies, providing an extensive selection of rigorously tested products designed for superior performance. Our dedicated team provides expert customer support, ensuring your research goals are achieved with great efficacy and accuracy. Whether you're investigating cell cycle regulation, cancer biology, or drug discovery, our anti-CDK4 antibodies offer precision and reliability.

CDK4: A Promising Target for Cancer Therapies

Cyclin-dependent kinase 4 (CDK4) is an essential cell cycle regulator, especially during the S phase transition. Its deregulation is commonly observed in various human tumors, such as breast cancer, gliomas, and melanomas, often through mechanisms like amplification or overexpression. Moreover, CDK4 has been identified as a prognostic marker, particularly in triple-negative breast cancer (TNBC). Owing to its noteworthy role in the advancement of cancer, CDK4 represents a very intriguing avenue for investigational cancer treatments.

Alternative Names

Cyclin-dependent kinase 4; CMM3; cyclin dependent kinase 4; cell division protein kinase 4; PSK-J3; EC 2.7.11.22; EC 2.7.11.

Background

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Anti-CDK4 rAb Products

Creative Biolabs offers a comprehensive range of anti-CDK4 antibodies designed to specifically block CDK4 protein. We offer our products in multiple formats to accommodate a wide array of experimental methods, ensuring seamless integration into your research workflows. In addition, we are committed to providing high-quality antibodies at competitive prices to meet the specific needs of researchers.

Table 1. Featured anti-CDK4 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is committed to empowering researchers with a diverse selection of high-quality anti-CDK4 antibodies. Each antibody undergoes stringent quality assurance processes to ensure exceptional performance in a variety of applications. Our dedication to excellence ensures that our products adhere to the highest standards in the industry, providing researchers with dependable and consistent results.

Customer Reviews

Excellent

Ku***u
Rabbit Anti-CDK4 Recombinant Antibody (clone CBACN-139) (MRO-0341-CN)

Creative Biolabs' anti-CDK4 antibody consistently demonstrated exceptional specificity and sensitivity in my Western blotting experiments. The antibody reliably detected CDK4 protein bands with minimal background interference, even at low protein concentrations. This high-quality performance has been invaluable in accurately quantifying CDK4 expression levels in various cell lines.

22/Oct/2021

Excellent

Al***n
Mouse Anti-CDK4 Recombinant Antibody (clone DCS31.2) (ZG-0794F)

I am highly satisfied with the performance of Creative Biolabs' anti-CDK4 antibody in immunoprecipitation experiments. The antibody efficiently pulled down CDK4 protein from cell lysates, resulting in clean immunoprecipitates with minimal non-specific binding. This enabled me to effectively analyze the interactions between CDK4 and its associated proteins.

17/Aug/2022

Excellent

Ch***s
Recombinant Rabbit Anti-CDK4 Antibody (clone R07-4G7) (VS3-FY348)

Creative Biolabs' anti-CDK4 antibody was a standout performer in my immunofluorescence studies. The antibody consistently yielded sharp, clear staining of CDK4 protein, allowing me to precisely visualize its subcellular distribution.

13/Nov/2023

rAb Production

Our advanced recombinant antibody platform leverages genetic engineering to produce high-performance anti-CDK4 antibodies. This cutting-edge system enables efficient and scalable manufacturing, ensuring a reliable supply for diverse applications.

Featured Anti-CDK4 Recombinant Antibody Production Platforms
Fig.5 Milligram-scale anti-CDK4 recombinant antibody production.

Fig.6 Gram-scale anti-CDK4 recombinant antibody production.

rAb Modalities

Creative Biolabs offers a wide range of high-quality anti-CDK4 recombinant antibodies in various formats to suit your specific research needs.

Fig.7 Full-length anti-CDK4 recombinant antibody production and modalities.

CDK4-Targeted Drug Information

Table 2. Public drug targeting CDK4.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

As a pioneer in antibody research, Creative Biolabs combines a strong theoretical foundation with extensive practical experience to deliver affordable, high-quality anti-CDK4 antibodies. If you want to learn more about our anti-CDK4 antibody, please feel free to contact us.