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    EGFR & HER2

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    Anti-EGFR & HER2 Products

    • Cetuximab (Gly-015CL)
      • CAS number: 205923-56-4
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    • Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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    • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
      • Target: EGFR
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
      • Target: EGFR
      • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MMAE (Monomethyl auristatin E)
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    • Anti-EGFR-mc-MMAF ADC (ADC-039CL)
      • Target: EGFR
      • Linker: Mc (maleimidocaproyl)
      • Drug: MMAF (Monomethyl auristatin F)
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    • Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
      • Target: epidermal growth factor receptor (EGFR)
      • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
      • Drug: MODO (monomethyldolastatin)
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    • Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
      • Target: EGFR variant III
      • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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    • Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
      • Target: EGFRvIII
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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    • Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
      • Target: EGFR
      • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
      • Drug: doxorubicin
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    • Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
      • Target: EGFR
      • Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
      • Drug: doxorubicin
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    • Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
      • Target: EGFR
      • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
      • Drug: MTX
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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
    EGFR & HER2
    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
    Related Diseases
    Bladder Cancer Bladder Cancer
    Breast Cancer Breast Cancer
    EGFR Tyrosine Kinase Inhibitor Resistance EGFR Tyrosine Kinase Inhibitor Resistance
    Non-small Cell Lung Cancer Non-small Cell Lung Cancer
    Pancreatic Cancer Pancreatic Cancer
    Endocrine Resistance Endocrine Resistance
    Hepatocellular Carcinoma Hepatocellular Carcinoma
    Cushing Syndrome Cushing Syndrome
    Related Signaling Pathways
    JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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