Human Anti-IFNG Recombinant Antibody (clone A4) (CAT#: FAMAB-1198CQ)

This product is a recombinant human antibody that recognizes IFNG. The antibody was purified by affinity chromatography. It can be used in ELISA.


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FC

Figure 1 Anti-mouse CD47 antagonist sdAb enhances macrophage-mediated ADCP.

Figure 1 Anti-mouse CD47 antagonist sdAb enhances macrophage-mediated ADCP.

Antibody-dependent phagocytosis of B16-F10 cells by bone marrow-derived C57BL/6J mouse macrophages treated with various combinations of control (αCD200) or tumor antigen-specific (αTRP-1) antibody with or without CD47 antagonist sdAb (A4).

Sockolosky, J. T., Dougan, M., Ingram, J. R., Ho, C. C. M., Kauke, M. J., Almo, S. C., ... & Garcia, K. C. (2016). Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proceedings of the National Academy of Sciences, 113(19), E2646-E2654.

Inhib

Figure 2 IFN-γ exposure inhibits antitumor antibody-dependent macrophage phagocytosis of B16F10 in vitro that can be rescued by combination PD-L1 and CD47 blockade.

Figure 2 IFN-γ exposure inhibits antitumor antibody-dependent macrophage phagocytosis of B16F10 in vitro that can be rescued by combination PD-L1 and CD47 blockade.

Antibody-dependent phagocytosis of IFN-γ-treated (gray bars) or untreated (white bars) B16-F10 cells by bone marrow-derived C57BL/6J mouse macrophages treated with various combinations of anti-PD-L1 and/or tumor antigen-specific (αTRP-1) antibody with or without CD47 antagonist sdAb (A4).

Sockolosky, J. T., Dougan, M., Ingram, J. R., Ho, C. C. M., Kauke, M. J., Almo, S. C., ... & Garcia, K. C. (2016). Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proceedings of the National Academy of Sciences, 113(19), E2646-E2654.


Specifications

  • Immunogen
  • Human IFN gamma
  • Host Species
  • Human
  • Type
  • Human IgG1
  • Specificity
  • Human Interferon gamma
  • Species Reactivity
  • Human
  • Clone
  • A4
  • Applications
  • Inhib, FC

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Flow Cytometry and Inhibition.

Target

  • Alternative Names
  • Interferon Gamma

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IFNG"

Humanized Antibody

Mouse Antibody

CAT Product Name Application Type
MOB-0289MC Recombinant Anti-Canine IFN-gamma Antibody. WB, ELISA

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0882LC Mouse Anti-IFNG Recombinant Antibody (clone MIF3009) ELISA Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-041 Afuco™ Anti-IFNG ADCC Recombinant Antibody (Fontolizumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody
AFC-TAB-423CQ Afuco™ Anti-IFNG ADCC Recombinant Antibody (Emapalumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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