Anti-Human CD28 Recombinant Antibody Fab Fragment (TGN1412)
CAT#: TAB-064LC-F(E)
TAB-064LC is a superagonistic monoclonal antibody (mAb) capable of fully activating T-cells by cross-linking CD28 molecules, even without signal 1, which sets it apart from conventional anti-CD28 mAbs. TAB-064LC-F(E) antibody is the Fab fragment antibody form of TAB-064LC antibody. Fab fragments, the antigen-binding domains of an antibody molecule, consist of two amino acid chains composed of VH+CH1 and VL+CL domains.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_9_8.jpg
Normal Tissue
Figure 2 Tonsil
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_6_8.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- TGN1412
- Applications
- FC
- Related Disease
- Inflammatory diseases, Autoimmune diseases
Target
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Ideal for T-cell Activation
TGN1412 has greatly facilitated our research into T-cell activation. Its specific targeting of CD28 has provided consistent and reliable results in our in vitro assays.
Flow Cytometry Compatible
Using TGN1412 in flow cytometry has provided detailed insights into T-cell subsets. Its binding to CD28 has facilitated precise analysis of activation markers in our studies.
Insightful Cytokine Production Studies
Using TGN1412 to stimulate T-cells has provided comprehensive insights into cytokine production. Our cytokine assays consistently show reproducible and significant results.
Q&As
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Is it possible to investigate T-cell activation in vitro using TGN1412?
A: Yes, TGN1412 is specifically designed to target human CD28, making it an excellent tool for investigating T-cell activation and proliferation in vitro, particularly in human immune cell assays.
-
In what ways does TGN1412 aid in the investigation of co-stimulatory signals in the activation of T cells?
A: TGN1412 binds to CD28 on T-cells, delivering a co-stimulatory signal that is crucial for T-cell activation. This property allows researchers to dissect the role of co-stimulation in T-cell responses.
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Is TGN1412 appropriate for T-cell activation investigation using flow cytometry?
A: Yes, TGN1412 can be used as a primary reagent in flow cytometry to study T-cell activation markers. It effectively binds to CD28, enabling detailed analysis of T-cell subsets.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-064LC-F(E), RRID: AB_3111786)
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Related Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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|---|---|---|---|
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| TAB-068LC-S(P) | Anti-Human CD28 Recombinant Antibody scFv Fragment (ChTN228) | FC, ELISA | Chimeric antibody (mouse/human) |
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| MOB-0354MZ | Mouse Anti-CD28 Recombinant Antibody (clone DD29.1) | ELISA | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4053 | Hi-Affi™ Rabbit Anti-CD28 Recombinant Antibody (clone SI120DS) | FC | Rabbit IgG |
| MOR-4054 | Hi-Affi™ Rabbit Anti-CD28 Recombinant Antibody (clone SI121DS) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0320YC-VH | Recombinant Humanized Anti-CD28 Single Domain Antibody (FAMAB-0320YC-VH) | ELISA | Humanized VH |
| FAMAB-0321YC-VH | Recombinant Humanized Anti-CD28 Single Domain Antibody (FAMAB-0321YC-VH) | ELISA | Humanized VH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0013-CN-S(P) | Mouse Anti-CD28 Recombinant Antibody (clone AV7); scFv Fragment | FC | Mouse scFv |
| HPAB-0245-FY-S(P) | Mouse Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-0245-FY-S(P)) | WB, IP, IF, FC | Mouse scFv |
| HPAB-0246-FY-S(P) | Mouse Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-0246-FY-S(P)) | FC, FuncS, ICC, IHC, IP, WB | Mouse scFv |
| HPAB-1489-FY-F(E) | Human Anti-CD28 Recombinant Antibody Fab Fragment (HPAB-1489-FY-F(E)) | WB, ELISA | Human Fab |
| HPAB-1144WJ-S(P) | Human Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-1144WJ-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY9 | Human Anti-CD28 Agonistic Antibody (VS-0724-XY9) | ELISA, Agonistic assays | Human IgG1 |
| VS-0724-XY10 | Mouse Anti-CD28 Agonistic Antibody (VS-0724-XY10) | WB, Agonistic assays | Mouse IgG1 |
| VS-0724-XY11 | Rat Anti-Cd28 Agonistic Antibody (VS-0724-XY11) | FC, Agonistic assays, CyTOF® | Rat IgG1 |
| VS-0724-XY12 | Rabbit Anti-Cd28 Agonistic Antibody (VS-0724-XY12) | FC, IF, IHC, Costim, Agonistic assays | Rabbit IgG, kappa |
| VS-0724-XY13 | Mouse Anti-Cd28 Agonistic Antibody (clone JJ316) | FC, IF, IHC, Costim, Agonistic assays | Mouse IgG1, kappa |
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