Anti-Human CD28 Recombinant Antibody scFv Fragment (TGN1412) (CAT#: TAB-064LC-S(P))
TAB-064LC is a superagonistic monoclonal antibody (mAb) capable of fully activating T-cells by cross-linking CD28 molecules, even without signal 1, which sets it apart from conventional anti-CD28 mAbs. TAB-064LC exhibits a binding affinity to human CD28, with an EC50 value of 4.4 nM. TAB-064LC exhibits a binding affinity to human T cells, with EC50 values measured at 2.5 nM. TAB-064LC-S(P) antibody is the scfv fragment antibody form of TAB-064LC antibody. Single-chain variable fragments (scFvs) are artificial constructs consisting of the variable regions of the immunoglobulin heavy and light chains connected by a peptide linker.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_9_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_9_8.jpg
Figure 2 Tonsil
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_6_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_6_8.jpg
Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- TGN1412
- Applications
- FC
- Related Disease
- Inflammatory diseases, Autoimmune diseases
Target
Related Resources
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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|---|---|---|---|
| MOB-0424ZL | Mouse Anti-CD28 Recombinant Antibody (clone CBLS-209) | FC, IP, WB, IHC, FuncS | Mouse IgG1 |
| MOB-0354MZ | Mouse Anti-CD28 Recombinant Antibody (clone DD29.1) | ELISA | Mouse IgG1 |
| HPAB-1144WJ | Human Anti-CD28 Recombinant Antibody (HPAB-1144WJ) | ELISA | Humanized IgG |
| ZG-0753F | Mouse Anti-CD28 Recombinant Antibody (clone B-23) | FC | Mouse IgG1 |
| VS-0624-FY71 | Mouse Anti-CD28 Recombinant Antibody (VS-0624-FY71) | FC, Costim | Mouse IgG1 kappa |
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For Research Use Only. Not For Clinical Use.
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