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Anti-Human EGFR Recombinant Antibody (07D06) (CAT#: TAB-316MZ)

This monoclonal antibody 07D06 that binds and inhibits activation of epidermal growth factor receptor can be potentially used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of EGFRL858R/T790M, EGFRvIII or wild-type EGFR amplification.

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Inhib

Figure 1 is graph summarizing results from an experiment to measure inhibition of rh-pro-EGF binding to rhEGFR by: negative control (murine IgG (Δ)), antibody 07D06 (■), antibody 12D03( A), cetuximab ( T), and panitumumab (♦).

Figure 1 is graph summarizing results from an experiment to measure inhibition of rh-pro-EGF binding to rhEGFR by: negative control (murine IgG (Δ)), antibody 07D06 (■), antibody 12D03( A), cetuximab ( T), and panitumumab (♦).

FuncS

Figure 2 is a graph summarizing results from an experiment to measure tumor growth inhibition by: antibody 07D06 (■), antibodyl2D03 (A ), cetuximab (·), panitumumab (♦), and a human IgG control (Δ) at a dose of 4 mg/kg (abbreviated as

Figure 2 is a graph summarizing results from an experiment to measure tumor growth inhibition by: antibody 07D06 (■), antibodyl2D03 (A ), cetuximab (·), panitumumab (♦), and a human IgG control (Δ) at a dose of 4 mg/kg (abbreviated as "mpk"), against lung chimeric EGFRL858R/T790M tumor xenografts in NCr nude mice.

FuncS

Figure 3 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 ( A ), antibodyl2D03 (■), cetuximab (·), and a human IgG control (Δ), at a dose of 0.5 mg/kg (abbreviated as

Figure 3 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 ( A ), antibodyl2D03 (■), cetuximab (·), and a human IgG control (Δ), at a dose of 0.5 mg/kg (abbreviated as "mpk"), against lung H1975 tumor xenografts in NCr nude mice.

FuncS

Figure 4 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 (■), antibody 12D03 ( A ), cetuximab (·), panitumumab (♦) and a human IgG control (Δ), at a dose of 5 mg/kg (abbreviated as

Figure 4 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 (■), antibody 12D03 ( A ), cetuximab (·), panitumumab (♦) and a human IgG control (Δ), at a dose of 5 mg/kg (abbreviated as "mpk"), against lung chimeric EGFRvIII tumor xenografts in NCr nude mice.

FuncS

Figure 5 is a graph summarizing results from an experiment to measure anti- proliferation activity of: negative control human IgG, antibody 07D06, and antibody 12D03, cetuximab and panitumumab in human primary keratinocytes.

Figure 5 is a graph summarizing results from an experiment to measure anti- proliferation activity of: negative control human IgG, antibody 07D06, and antibody 12D03, cetuximab and panitumumab in human primary keratinocytes.


Specifications

  • Immunogen
  • Recombinant human EGFR/Fc
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • 07D06
  • Applications
  • FuncS, Inhib
  • Related Disease
  • Non-small cell lung cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay, Inhibition.

Target

  • Alternative Names
  • EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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CAT Product Name Application Type
NABG-056 Recombinant Anti-Mouse Egfr VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH
HPAB-AP881-YC Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP881-YC) ELISA, FC, IP, FuncS Llama VHH
HPAB-AP882-YC Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP882-YC) ELISA Llama VHH
HPAB-AP883-YC Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP883-YC) ELISA Llama VHH
HPAB-AP884-YC Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP884-YC) ELISA Llama VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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