Anti-Human EGFR Recombinant Antibody (12D03) (CAT#: TAB-317MZ)

This monoclonal antibody 12D03 that binds and inhibits activation of epidermal growth factor receptor can be potentially used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of EGFRL858R/T790M, EGFRvIII or wild-type EGFR amplification.


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Inhib

Figure 1 is graph summarizing results from an experiment to measure inhibition of rh-pro-EGF binding to rhEGFR by: negative control (murine IgG (Δ)), antibody 07D06 (■), antibody 12D03( A), cetuximab ( T), and panitumumab (♦).

Figure 1 is graph summarizing results from an experiment to measure inhibition of rh-pro-EGF binding to rhEGFR by: negative control (murine IgG (Δ)), antibody 07D06 (■), antibody 12D03( A), cetuximab ( T), and panitumumab (♦).

FuncS

Figure 2 is a graph summarizing results from an experiment to measure tumor growth inhibition by: antibody 07D06 (■), antibodyl2D03 (A ), cetuximab (·), panitumumab (♦), and a human IgG control (Δ) at a dose of 4 mg/kg (abbreviated as

Figure 2 is a graph summarizing results from an experiment to measure tumor growth inhibition by: antibody 07D06 (■), antibodyl2D03 (A ), cetuximab (·), panitumumab (♦), and a human IgG control (Δ) at a dose of 4 mg/kg (abbreviated as "mpk"), against lung chimeric EGFRL858R/T790M tumor xenografts in NCr nude mice.

FuncS

Figure 3 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 ( A ), antibodyl2D03 (■), cetuximab (·), and a human IgG control (Δ), at a dose of 0.5 mg/kg (abbreviated as

Figure 3 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 ( A ), antibodyl2D03 (■), cetuximab (·), and a human IgG control (Δ), at a dose of 0.5 mg/kg (abbreviated as "mpk"), against lung H1975 tumor xenografts in NCr nude mice.

FuncS

Figure 4 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 (■), antibody 12D03 ( A ), cetuximab (·), panitumumab (♦) and a human IgG control (Δ), at a dose of 5 mg/kg (abbreviated as

Figure 4 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 (■), antibody 12D03 ( A ), cetuximab (·), panitumumab (♦) and a human IgG control (Δ), at a dose of 5 mg/kg (abbreviated as "mpk"), against lung chimeric EGFRvIII tumor xenografts in NCr nude mice.

FuncS

Figure 5 is a graph summarizing results from an experiment to measure anti- proliferation activity of: negative control human IgG, antibody 07D06, and antibody 12D03, cetuximab and panitumumab in human primary keratinocytes.

Figure 5 is a graph summarizing results from an experiment to measure anti- proliferation activity of: negative control human IgG, antibody 07D06, and antibody 12D03, cetuximab and panitumumab in human primary keratinocytes.


Specifications

  • Immunogen
  • Recombinant human EGFR/Fc
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • 12D03
  • Applications
  • FuncS, Inhib
  • Related Disease
  • Non-small cell lung cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay, Inhibition.

Target

  • Alternative Names
  • EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 12D03"

See other products for "EGFR"

Humanized Antibody

CAT Product Name Application Type
TAB-165 Anti-Human EGFR Recombinant Antibody (Matuzumab) Neut, ELISA, IF, IP, FuncS, FC, ICC IgG1
TAB-710 Anti-EGFR Recombinant Antibody (Nimotuzumab) ELISA, IP, FC, FuncS, Neut, IF, IHC IgG1 - kappa
TAB-274MZ Human Anti-EGFR Recombinant Antibody (TAB-274MZ) FC Humanized IgG
TAB-297MZ Anti-Human EGFR Recombinant Antibody (H225) ELISA, WB Humanized antibody
TAB-274MZ-S(P) Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-274MZ-S(P)) FC Humanized scFv

Fc Glycosylation

High-mannose Glycoform

CAT Product Name Application Type
Gly-055LC-1 Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) ELISA Chimeric antibody (mouse/human)

Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-167LC Recombinant Anti-Human EGFR Antibody (Non-glycosylated) ELISA Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0183MZ Chicken Anti-EGFR Polyclonal IgY WB Chicken antibody
BRD-0668MZ Chicken Anti-EGFR Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-165 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Matuzumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-464CQ Afuco™ Anti-EGFR ADCC Recombinant Antibody (Tomuzotuximab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody
AFC-TAB-003 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Cetuximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-040 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Zalutumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-119 Afuco™ Anti-EGFR ADCC Recombinant Antibody (Necitumumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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