Anti-Human EGFR Recombinant Antibody (12D03) (CAT#: TAB-317MZ)
This monoclonal antibody 12D03 that binds and inhibits activation of epidermal growth factor receptor can be potentially used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of EGFRL858R/T790M, EGFRvIII or wild-type EGFR amplification.
Specific Inquiry
Inhib
Figure 1 is graph summarizing results from an experiment to measure inhibition of rh-pro-EGF binding to rhEGFR by: negative control (murine IgG (Δ)), antibody 07D06 (■), antibody 12D03( A), cetuximab ( T), and panitumumab (♦).
FuncS
Figure 2 is a graph summarizing results from an experiment to measure tumor growth inhibition by: antibody 07D06 (■), antibodyl2D03 (A ), cetuximab (·), panitumumab (♦), and a human IgG control (Δ) at a dose of 4 mg/kg (abbreviated as "mpk"), against lung chimeric EGFRL858R/T790M tumor xenografts in NCr nude mice.
FuncS
Figure 3 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 ( A ), antibodyl2D03 (■), cetuximab (·), and a human IgG control (Δ), at a dose of 0.5 mg/kg (abbreviated as "mpk"), against lung H1975 tumor xenografts in NCr nude mice.
FuncS
Figure 4 is a graph summarizing results from an experiment to measure tumor growth inhibition by antibody 07D06 (■), antibody 12D03 ( A ), cetuximab (·), panitumumab (♦) and a human IgG control (Δ), at a dose of 5 mg/kg (abbreviated as "mpk"), against lung chimeric EGFRvIII tumor xenografts in NCr nude mice.
FuncS
Figure 5 is a graph summarizing results from an experiment to measure anti- proliferation activity of: negative control human IgG, antibody 07D06, and antibody 12D03, cetuximab and panitumumab in human primary keratinocytes.
Specifications
- Immunogen
- Recombinant human EGFR/Fc
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 12D03
- Applications
- FuncS, Inhib
- Related Disease
- Non-small cell lung cancer
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Inhibition.
Target
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- Gene ID
- 1956
- UniProt ID
- P00533
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Hepatocellular Carcinoma
Cushing Syndrome
JAK-STAT Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-750 | Anti-EGFR/HER1 Recombinant Antibody (TAB-750) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG1 - kappa |
| TAB-003 | Anti-Human EGFR Recombinant Antibody (Cetuximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
| TAB-H49 | Anti-Human EGFR Recombinant Antibody (Modotuximab) | FuncS, IF, Neut, ELISA, FC, IP, IHC | IgG1 - kappa |
| PABX-051 | Recombinant Human Anti-EGFR Antibody (Matuzumab) | WB, Neut, FuncS, FC, ELISA, IF, Inhib | IgG |
| PABX-051-F (E) | Recombinant Mouse Anti-EGFR Antibody Fab Fragment (Matuzumab) | WB, Neut, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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