This product is a humanized V-kappa antibody that can recognize human CD28.
Figure 1 Mean lulizumab serum concentration profile vs time.
Mean (SD) lulizumab serum concentration profile vs time is shown on a log‐linear scale. (A) IV treatment in the SAD study; (B) SC treatment in the SAD study; (C) day 1 of the MAD study; (D) day 29 of the MAD study. IV, intravenous; MAD, multiple‐ascending dose; SAD, single‐ascending dose; SC, subcutaneous; SD, standard deviation.
Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.
Figure 2 lulizumab inhibited antibody production against KLH for 2 weeks, demonstrating immunosuppressive activity.
(A) Lulizumab suppression on KLH‐induced IgG response at days 8, 15, and 29 after single IV dose administration in healthy subjects in the SAD study; (B) mean CD4 cell CD28 receptor occupancy in the KLH panels of the SAD study. IgG, immunoglobulin G; IV, intravenous; KLH, keyhole limpet hemocyanin; SAD, single‐ascending dose.
Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-981 | Mouse Anti-CD28 Recombinant Antibody (clone ANC28.1/5D10); F(ab')2 Fragment | Agonist, Stim, Neu, FC | Mouse IgG1 F(ab')2, κ |
PFBL-365 | Mouse Anti-CD28 Recombinant Antibody (clone 1C6); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
HPAB-0132CQ-F(E) | Human Anti-CD28 Recombinant Antibody (clone FR255734); Fab Fragment | ELISA, IHC, Block | Human Fab |
HPAB-1489-FY-S(P) | Human Anti-CD28 Recombinant Antibody (clone 2E12); Fab Fragment | WB, ELISA | Human Fab |
HPAB-1144WJ-F(E) | Human Anti-CD28 Recombinant Antibody; Fab Fragment (HPAB-1144WJ-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-365 | Mouse Anti-CD28 Recombinant Antibody (clone 1C6); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
FAMAB-0013-CN-S(P) | Mouse Anti-CD28 Recombinant Antibody (clone AV7); scFv Fragment | FC | Mouse scFv |
HPAB-1489-FY-F(E) | Human Anti-CD28 Recombinant Antibody (clone 2E12); scFv Fragment | WB, ELISA | Human scFv |
HPAB-1144WJ-S(P) | Human Anti-CD28 Recombinant Antibody; scFv Fragment (HPAB-1144WJ-S(P)) | ELISA | Humanized scFv |
HPAB-1589WJ-S(P) | Mouse Anti-CD28 Recombinant Antibody; scFv Fragment (clone 2E12) | ELISA, WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-064LC | Anti-Human CD28 Recombinant Antibody (TGN1412) | FC, Stim | Humanized antibody |
TAB-064LC-F(E) | Anti-Human CD28 Recombinant Antibody Fab Fragment (TGN1412) | FC | Humanized antibody |
TAB-065LC-F(E) | Human Anti-CD28 Recombinant Antibody; Fab Fragment (TAB-065LC-F(E)) | ELISA | Humanized Fab |
TAB-066LC-F(E) | Human Anti-CD28 Recombinant Antibody; Fab Fragment (TAB-066LC-F(E)) | ELISA | Humanized Fab |
TAB-069LC-F(E) | Anti-Human CD28 Recombinant Antibody Fab Fragment (HuTN228) | FC, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-068LC | Anti-Human CD28 Recombinant Antibody (ChTN228) | ELISA, FC | Chimeric antibody (mouse/human) |
TAB-068LC-S(P) | Anti-Human CD28 Recombinant Antibody scFv Fragment (ChTN228) | FC, ELISA | Chimeric antibody (mouse/human) |
TAB-068LC-F(E) | Anti-Human CD28 Recombinant Antibody Fab Fragment (ChTN228) | FC, ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-031 | Recombinant Mouse Anti-CD28 Antibody (5.11A1) | WB, ELISA, FuncS, Activ | IgG |
PABX-031-F (E) | Recombinant Mouse Anti-CD28 Antibody Fab Fragment (5.11A1) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-031-S (P) | Recombinant Mouse Anti-CD28 Antibody scFv Fragment (5.11A1) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-334CQ | Mouse Anti-CD28 Recombinant Antibody (clone CD28.6) | FC, FuncS, Neut, WB | Mouse IgG2a, κ |
NEUT-337CQ | Hamster Anti-CD28 Recombinant Antibody (clone MAB0818) | Neut | Hamster IgG1 |
NEUT-338CQ | Hamster Anti-CD28 Recombinant Antibody (clone PV-1) | ELISA, FC, Neut | Hamster IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-335CQ | Hamster Anti-CD28 Recombinant Antibody (clone 37.51) | IHC-Fr, FC, IP, Block, FuncS | Hamster IgG |
NEUT-336CQ | Mouse Anti-CD28 Recombinant Antibody (clone E18) | FC, Costim, Block | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4053 | Hi-Affi™ Rabbit Anti-CD28 Recombinant Antibody (clone SI120DS) | FC | Rabbit IgG |
MOR-4054 | Hi-Affi™ Rabbit Anti-CD28 Recombinant Antibody (clone SI121DS) | ELISA, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0320YC-VH | Recombinant Humanized Anti-CD28 Single Domain Antibody (re-CD28 clone 1) | ELISA | Humanized VH |
FAMAB-0321YC-VH | Recombinant Humanized Anti-CD28 Single Domain Antibody (re-CD28 clone 2) | ELISA | Humanized VH |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0132CQ | Human Anti-CD28 Recombinant Antibody (clone FR255734) | ELISA, IHC, Block, FuncS | Human IgG2M3, κ |
HPAB-0245-FY | Mouse Anti-CD28 Recombinant Antibody (HPAB-0245-FY) | WB, IP, IF, FC | Mouse IgG1 |
HPAB-0246-FY | Mouse Anti-CD28 Recombinant Antibody (HPAB-0246-FY) | FC, FuncS, ICC, IHC, IP, WB | Mouse IgG1 |
FN-086CQ | Mouse Anti-CD28 Recombinant Antibody (clone CD28.2) | IHC-Fr, FC, IP | Mouse IgG1, κ |
FN-121CQ | Mouse Anti-CD28 Recombinant Antibody (clone 15E8) | FuncS, Activ | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H47 | Afuco™ Anti-CD28 ADCC Recombinant Antibody (Lumretuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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