Humanized Anti-CD28 Recombinant Antibody (clone Lulizumab) (CAT#: TAB-H46)

This product is a humanized V-kappa antibody that can recognize human CD28.


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  • Endotoxin:
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  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Mean lulizumab serum concentration profile vs time.

Figure 1 Mean lulizumab serum concentration profile vs time.

Mean (SD) lulizumab serum concentration profile vs time is shown on a log‐linear scale. (A) IV treatment in the SAD study; (B) SC treatment in the SAD study; (C) day 1 of the MAD study; (D) day 29 of the MAD study. IV, intravenous; MAD, multiple‐ascending dose; SAD, single‐ascending dose; SC, subcutaneous; SD, standard deviation.

Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.

Figure 2 lulizumab inhibited antibody production against KLH for 2 weeks, demonstrating immunosuppressive activity.

Figure 2 lulizumab inhibited antibody production against KLH for 2 weeks, demonstrating immunosuppressive activity.

(A) Lulizumab suppression on KLH‐induced IgG response at days 8, 15, and 29 after single IV dose administration in healthy subjects in the SAD study; (B) mean CD4 cell CD28 receptor occupancy in the KLH panels of the SAD study. IgG, immunoglobulin G; IV, intravenous; KLH, keyhole limpet hemocyanin; SAD, single‐ascending dose.

Shi, R., Honczarenko, M., Zhang, S., Fleener, C., Mora, J., Lee, S. K., ... & Wang, H. (2017). Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects. The Journal of Clinical Pharmacology, 57(2), 161-172.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized V-kappa
  • Specificity
  • Human CD28
  • Species Reactivity
  • Human
  • Clone
  • Lulizumab
  • Applications
  • IP, IF, FuncS, FC, Neut, ELISA, IHC

Product Property

  • Purification
  • Affinity Purified
  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Immunoprecipitation, Immunofluorescence, Functional Assay, Flow Cytometry, Neutralization, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.

Target

  • Alternative Names
  • Tp44; T-cell-specific surface glycoprotein CD28; CD28 molecule

Related Resources

  • Biosimilar Overview
  • Related Diseases
Please refer to Lulizumab Pegol Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lulizumab Pegol.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CD28"

Chimeric Antibody

CAT Product Name Application Type
TAB-068LC Anti-Human CD28 Recombinant Antibody (ChTN228) ELISA, FC Chimeric antibody (mouse/human)
TAB-068LC-S(P) Anti-Human CD28 Recombinant Antibody scFv Fragment (ChTN228) FC, ELISA Chimeric antibody (mouse/human)
TAB-068LC-F(E) Anti-Human CD28 Recombinant Antibody Fab Fragment (ChTN228) FC, ELISA Chimeric antibody (mouse/human)

Mouse Antibody

CAT Product Name Application Type
PABX-031 Recombinant Mouse Anti-CD28 Antibody (5.11A1) WB, ELISA, FuncS, Activ IgG
PABX-031-F (E) Recombinant Mouse Anti-CD28 Antibody Fab Fragment (5.11A1) WB, ELISA, FuncS Fab

Human Antibody

CAT Product Name Application Type
PABX-031-S (P) Recombinant Mouse Anti-CD28 Antibody scFv Fragment (5.11A1) WB, ELISA, FuncS scFv

Neutralizing Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-335CQ Hamster Anti-CD28 Recombinant Antibody (clone 37.51) IHC-Fr, FC, IP, Block, FuncS Hamster IgG
NEUT-336CQ Mouse Anti-CD28 Recombinant Antibody (clone E18) FC, Costim, Block Mouse IgG2b, κ

Rabbit Monoclonal Antibody

Recombinant Antibody

CAT Product Name Application Type
HPAB-0132CQ Human Anti-CD28 Recombinant Antibody (clone FR255734) ELISA, IHC, Block, FuncS Human IgG2M3, κ
HPAB-0245-FY Mouse Anti-CD28 Recombinant Antibody (HPAB-0245-FY) WB, IP, IF, FC Mouse IgG1
HPAB-0246-FY Mouse Anti-CD28 Recombinant Antibody (HPAB-0246-FY) FC, FuncS, ICC, IHC, IP, WB Mouse IgG1
FN-086CQ Mouse Anti-CD28 Recombinant Antibody (clone CD28.2) IHC-Fr, FC, IP Mouse IgG1, κ
FN-121CQ Mouse Anti-CD28 Recombinant Antibody (clone 15E8) FuncS, Activ Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H47 Afuco™ Anti-CD28 ADCC Recombinant Antibody (Lumretuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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