Anti-Human IL31RA Recombinant Antibody (TAB-439CQ)
CAT#: TAB-439CQ
Recombinant monoclonal antibody to IL31RA. This antibody is a humanized monoclonal antibody that binds specifically to IL-31RA, blocking the interaction between IL-31 and its receptor.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lung
Immunohistochemical staining of human lung shows moderate cytoplasmic positivity in macrophages.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_3_4_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/986_C6_2_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51532/832_C6_4_red_green.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68114/160946_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (GAMG, HBEC3-KT, HHSteC, hTERT-HME1, U-2 OS, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164509-IL31RA
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- IgG2, κ
- Specificity
- Human IL31RA
- Species Reactivity
- Human
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- Related Disease
- Atopic dermatitis, Pruritus
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The IL31RA antibody has been reported in applications of Neut, Inhib.
Inhibition: To investigate the inhibition of native IL‐31 signalling by nemolizumab, A549 cells were cultured in F‐12K medium (Life Technologies, Tokyo, Japan) containing 10% foetal bovine serum (FBS) and 100 units/mL penicillin‐100 μg/mL streptomycin in 24‐well plates) overnight. Next, the cells were treated with nemolizumab for 2 hours and then hIL‐31 was added. After incubation for 20 minutes, cells were lysed and the phosphorylation of STAT3 was analysed with the PathScan Phospho‐Stat3 (Tyr705) Sandwich ELISA Kit.
Target
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Perfect for Flow Cytometry Applications
The antibody's compatibility with flow cytometry has made sorting IL31RA-expressing cells seamless. Its high binding affinity ensures clarity and precision, elevating our cell sorting experiments.
Reliable Across Various Sample Types
We've deployed this antibody in numerous sample types from tissue to cell lines, and the results have been consistently reliable, proving its adaptability in diverse research scenarios.
Crucial for Understanding Inflammatory Mechanisms
The insights gained from using this antibody in inflammation research have been significant. Its role in dissecting IL31RA-related pathways has pushed our research to new levels.
Versatile and Cost-effective
Given its wide applicability and robust performance, TAB-439CQ offers excellent value, providing cost-effectiveness alongside top-notch performance in our research.
Facilitates Deeper Insight into Immune Research
Especially in autoimmune and inflammatory disease models, this antibody allows deeper exploration into IL31RA's role, driving more insightful conclusions in our studies.
Q&As
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What is the primary target of the Anti-Human IL31RA Recombinant Antibody?
A: The primary target is the IL31RA, a receptor involved in mediating the biological effects of the cytokine IL-31. It's relevant in research focusing on inflammatory responses.
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What makes the Anti-Human IL31RA Antibody suitable for immunoprecipitation?
A: Its high affinity and specificity for IL31RA ensure accurate protein capture, which is essential for immunoprecipitation applications.
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Is the antibody suitable for flow cytometry?
A: Yes, it is suitable for flow cytometry applications, enabling the study of IL31RA expression on cell surfaces.
-
Which signaling pathways are primarily affected by IL31RA?
A: IL31RA is involved in the JAK/STAT signaling pathway, making this antibody useful for related research investigations.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-439CQ, RRID: AB_3111945)
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Biosimilar Overview
Please refer to Nemolizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Nemolizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "IL31RA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0972CT | Recombinant Mouse anti-Human IL31RA Monoclonal antibody (EML2192) | WB | |
| MOB-168CQ | Mouse Anti-IL31RA Recombinant Antibody (clone YC131) | ELISA, WB, IF, IP | Mouse IgG2a, κ |
| MOB-175CQ | Human Anti-IL31RA Recombinant Antibody (MOB-175CQ) | ELISA, FC | Chimeric (mouse/human) IgG |
| HPAB-J0130-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0130-YC) | Inhib | Mouse IgG |
| HPAB-J0131-YC | Mouse Anti-IL31RA Recombinant Antibody (HPAB-J0131-YC) | Inhib, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-439CQ | Afuco™ Anti-IL31RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-439CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1243-FY-F(E) | Human Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-1243-FY-F(E)) | Neut | Human Fab |
| HPAB-J0130-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0130-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0131-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0131-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0132-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0132-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0133-YC-S(P) | Mouse Anti-IL31RA Recombinant Antibody; scFv Fragment (HPAB-J0133-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0130-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0130-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0131-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0131-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0132-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0132-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0133-YC-F(E) | Mouse Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0133-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0134-YC-F(E) | Human Anti-IL31RA Recombinant Antibody; Fab Fragment (HPAB-J0134-YC-F(E)) | ELISA, Inhib | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY129 | Human Anti-IL31RA scFv-Fc Chimera (VS-0425-FY129) | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC523 | Recombinant Anti-IL31RA Vesicular Antibody, EV Displayed (VS-0425-YC523) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3527 | Anti-IL31RA Immunohistochemistry Kit | IHC |
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