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    Rabbit Anti-BMI1 Antibody (VS-0924-YC22) - Cancer Stem Cell Marker (CAT#: VS-0924-YC22)

    This anti-BMI1 antibody (VS-0924-YC22) targets BMI1 protein in humans, mice, and rats, serving as a marker for cancer stem cells (CSCs). It can be used for detecting BMI1 in CSC tissues or cells by Immunohistochemistry (1/50-1/200) and Western blot (0.1-0.5 µg/mL).

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Fc Engineering:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HEK 293
    Figure 1 IF staining of human cell line HEK 293
    (Immunofluorescent staining of human cell line HEK 293 shows localization to nuclear bodies.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30471/1564_A5_1_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/30472/if_selected.jpg
    Normal Tissue
    Figure 3 IHC staining of human adrenal gland
    Figure 3 IHC staining of human adrenal gland
    (Immunohistochemical staining of human adrenal gland shows strong nuclear positivity in cortical cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11120/ihc_selected.jpg
    Figure 4 Testis
    Figure 4 Testis
    (Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11120/34651_A_6_6.jpg
    Figure 5 Lymph node
    Figure 5 Lymph node
    (Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11120/34651_A_8_8.jpg
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11120/34651_B_8_5.jpg
    Figure 7 Nasopharynx
    Figure 7 Nasopharynx
    (Respiratory epithelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11120/34651_B_8_2.jpg
    Figure 8 Colon
    Figure 8 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11120/34651_A_7_3.jpg
    Figure 9 Kidney
    Figure 9 Kidney
    (Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11120/34651_A_7_5.jpg
    RNA Expression
    Figure 10 RNA cell line category: Cell line enhanced (HDLM-2, U-937)
    Figure 10 RNA cell line category: Cell line enhanced (HDLM-2, U-937)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168283-BMI1

    Specifications

    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse and Rat BMI1
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • IHC, WB

    Product Property

    • Clonality
    • Polyclonal
    • Purification
    • Affinity purified using the PrEST antigen as affinity ligand
    • Concentration
    • 0.2 mg/mL
    • Buffer
    • PBS, pH 7.2, with 40% glycerol
    • Preservative
    • 0.02% Sodium azide
    • Storage
    • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Immunohistochemistry (IHC): 1/50-1/200
      Western Blot (WB): 0.1-0.5 µg/mL

    Target

    • Alternative Names
    • PCGF4; RNF51
    • Long Name
    • BMI1 proto-oncogene, polycomb ring finger
    • Cellular Localization
    • Cytoplasm, Nucleus
    • Function
    • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
      The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A.
      In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.

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    See other products for "BMI1"

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    IgG Antibody Products Rabbit Monoclonal Antibody Products MHC Tetramer Products for Cancer Antibody Magnetic Beads Cancer Stem Cell Biomarker Specific Antibody Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
    CAT Product Name Application Type
    MOB-4024z Mouse Anti-BMI1 Recombinant Antibody (clone 43H11) WB, FC, ICC, IF, IHC Mouse IgG1
    MRO-0184-CN Mouse Anti-BMI1 Recombinant Antibody (clone A11-C11) WB, IHC, IF Mouse IgG2a
    MRO-0185-CN Rabbit Anti-BMI1 Recombinant Antibody (clone CBACN-072) WB, IF, IHC Rabbit IgG
    MRO-0186-CN Mouse Anti-BMI1 Recombinant Antibody (clone B3-G5) WB, IF, IHC, FC Mouse IgG2a
    VS3-CJ101 Mouse Anti-BMI1 Recombinant Antibody (VS3-CJ101) WB, ELISA Mouse IgG

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