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    Mouse Anti-Cd28 Recombinant Antibody (clone JJ-316)

    CAT#: HPAB-0078-YJ

    This product is a recombinant mouse antibody that recognizes rat CD28. Mab JJ316 can convey as a co-stimulatory signal. Administration of the CD28 superagonistic antibody JJ316 is an efficient means to treat autoimmune diseases in rats. JJ316 treatment of rats can induce a dramatic redistribution of T lymphocytes from the periphery to the secondary lymphoid organs, resulting in severe T lymphopenia.

    Gene Expression
    ❮
    Figure 1 Lymph node Figure 2 Tonsil Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
    ❯

    Specifications

    • Host Species
    • Mouse
    • Type
    • Mouse IgG1, κ
    • Specificity
    • Rat
    • Species Reactivity
    • Rat
    • Clone
    • JJ-316
    • Applications
    • Costim, Agonist, FC, IF, IHC, FuncS
    • Related Disease
    • Multiple Sclerosis, Autoimmune Diseases

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE and HPLC analysis
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • This antibody has been tested for use in Functional Assay.

    Target

    • Alternative Names
    • CD28 Molecule; CD28 Antigen; Tp44; T-Cell-Specific Surface Glycoprotein CD28; T-Cell-Specific Surface Glycoprotein; CD28 Antigen (Tp44); CD28RNA; JJ-316; JJ316
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    Related Diseases

    Rheumatoid Arthritis Rheumatoid Arthritis
    Systemic Lupus Erythematosus Systemic Lupus Erythematosus
    Allograft Rejection Allograft Rejection
    Autoimmune Thyroid Disease Autoimmune Thyroid Disease
    Graft-versus-Host Disease Graft-versus-Host Disease
    Maturity Onset Diabetes of the Young Maturity Onset Diabetes of the Young

    Downloadable Resources

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Datasheet

    Datasheet - HPAB-0078-YJ.pdf

    MSDS

    MSDS - HPAB-0078-YJ.pdf

    COA

    Certificate of Analysis Lookup

    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

    Lot Number:

    Protocol & Troubleshooting

    Immunofluorescence (IF)
    Immunohistochemistry (IHC)

    We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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