Human Anti-EGFR Recombinant Antibody (clone E10) (CAT#: FAMAB-0202-CN)

This is a human antibody against EGFR derived from a large naive human scFv phage library, Griffin.1 library. The E10 has the potential to be developed as therapeutic agents to solid tumors associated with EGFR overexpression.

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Inhib

Figure 1 Inhibition on A431 cells proliferation by scFvs.

Figure 1 Inhibition on A431 cells proliferation by scFvs.

The concentrations of scFv E10 were 200, 100, 50, 25, 12.5, 2.5 nM. The concentrations of scFv 11F8 were 120, 60, 30, 15, 7.5 nM by doubling dilution.

Zhou, Y., Zhang, J., Jin, H., Chen, Z., Wu, Q., Li, W., Yue, M., Luo, C., & Wang, M. (2013). Prokaryotic expression and refolding of EGFR extracellular domain and generation of phage display human scFv against EGFR. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 67(8), 737–743.


Specifications

  • Immunogen
  • EGFR-truncated extracellular domain (EGFR-tED)
  • Host Species
  • Human
  • Derivation
  • Phage display library
  • Type
  • Human IgG
  • Specificity
  • Human EGFR
  • Species Reactivity
  • Human
  • Clone
  • E10
  • Applications
  • ELISA, WB
  • Related Disease
  • Solid tumors

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Epidermal Growth Factor Receptor 2; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 2.7.10.1; ERBB1; ERBB; HER1; Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian); Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog; Cell Proliferation-Inducing Protein 61; Cell Growth Inhibiting Protein 40; EC 2.7.10; NISBD2; PIG61; MENA

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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