This is a human antibody against EGFR derived from a large naive human scFv phage library, Griffin.1 library. The E10 has the potential to be developed as therapeutic agents to solid tumors associated with EGFR overexpression.
Figure 1 Inhibition on A431 cells proliferation by scFvs.
The concentrations of scFv E10 were 200, 100, 50, 25, 12.5, 2.5 nM. The concentrations of scFv 11F8 were 120, 60, 30, 15, 7.5 nM by doubling dilution.
Zhou, Y., Zhang, J., Jin, H., Chen, Z., Wu, Q., Li, W., Yue, M., Luo, C., & Wang, M. (2013). Prokaryotic expression and refolding of EGFR extracellular domain and generation of phage display human scFv against EGFR. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 67(8), 737–743.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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